Triptolide-induced cell death in pancreatic cancer is mediated by O-GlcNAc modification of transcription factor Sp1.
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Triptolide activates unfolded protein response leading to chronic ER stress in pancreatic cancer cells.Risk factors for pancreatic cancer: underlying mechanisms and potential targets.O-GlcNAc signaling in cancer metabolism and epigeneticsTriptolide inhibits cell proliferation and tumorigenicity of human neuroblastoma cells.NZ28-induced inhibition of HSF1, SP1 and NF-κB triggers the loss of the natural killer cell-activating ligands MICA/B on human tumor cells.Suppression of the migration and invasion is mediated by triptolide in B16F10 mouse melanoma cells through the NF-kappaB-dependent pathway.Downregulation of Sp1 by Minnelide leads to decrease in HSP70 and decrease in tumor burden of gastric cancerTargeting HSF1 disrupts HSP90 chaperone function in chronic lymphocytic leukemia.Triptolide abrogates growth of colon cancer and induces cell cycle arrest by inhibiting transcriptional activation of E2F.Inhibition of NF-kappa B pathway leads to deregulation of epithelial-mesenchymal transition and neural invasion in pancreatic cancerTranscription factor Sp1, also known as specificity protein 1 as a therapeutic target.Targets and molecular mechanisms of triptolide in cancer therapy.Control of Apoptosis in Treatment and Biology of Pancreatic Cancer.Minnelide Inhibits Androgen Dependent, Castration Resistant Prostate Cancer Growth by Decreasing Expression of Androgen Receptor Full Length and Splice Variants.Impaired Synthesis of Stromal Components in Response to Minnelide Improves Vascular Function, Drug Delivery, and Survival in Pancreatic Cancer.JMJD2A-dependent silencing of Sp1 in advanced breast cancer promotes metastasis by downregulation of DIRAS3.SP and KLF Transcription Factors in Digestive Physiology and Diseases."Heat shock protein 70 in pancreatic diseases: Friend or foe".Triptolide reduces the viability of osteosarcoma cells by reducing MKP-1 and Hsp70 expression.Metabolic Characteristics of 16HBE and A549 Cells Exposed to Different Surface Modified Gold Nanorods.Triptolide potentiates lung cancer cells to cisplatin-induced apoptosis by selectively inhibiting the NER activity.Inhibition of hypoxic response decreases stemness and reduces tumorigenic signaling due to impaired assembly of HIF1 transcription complex in pancreatic cancer.Effect of the Natural Product Triptolide on Pancreatic Cancer: A Systematic Review of Preclinical StudiesInhibition of Sp1 prevents ER homeostasis and causes cell death by lysosomal membrane permeabilization in pancreatic cancer.Glucosamine-induced Sp1 O-GlcNAcylation ameliorates hypoxia-induced SGLT dysfunction in primary cultured renal proximal tubule cells.Quantitative Proteomics and Targeted Fatty Acids Analysis Reveal the Damage of Triptolide in Liver and Kidney.Triptolide and celastrol loaded silk fibroin nanoparticles show synergistic effect against human pancreatic cancer cells.Inactivation of cancer-associated-fibroblasts (CAF) disrupts oncogenic signaling in pancreatic cancer cells and promotes its regression.Hyperglycemia and aberrant O-GlcNAcylation: contributions to tumor progression.Antitumor effect of triptolide in T-cell lymphoblastic lymphoma by inhibiting cell viability, invasion, and epithelial-mesenchymal transition via regulating the PI3K/AKT/mTOR pathway.GRP78-mediated antioxidant response and ABC transporter activity confers chemoresistance to pancreatic cancer cells.The Nutrient-Sensing Hexosamine Biosynthetic Pathway as the Hub of Cancer Metabolic Rewiring.Triptolide inhibits Epstein-Barr nuclear antigen 1 expression by increasing sensitivity of mitochondria apoptosis of nasopharyngeal carcinoma cellsNano and Microsensors for Mammalian Cell Studies
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Triptolide-induced cell death in pancreatic cancer is mediated by O-GlcNAc modification of transcription factor Sp1.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 15 October 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Triptolide-induced cell death ...... n of transcription factor Sp1.
@en
Triptolide-induced cell death ...... n of transcription factor Sp1.
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type
label
Triptolide-induced cell death ...... n of transcription factor Sp1.
@en
Triptolide-induced cell death ...... n of transcription factor Sp1.
@nl
prefLabel
Triptolide-induced cell death ...... n of transcription factor Sp1.
@en
Triptolide-induced cell death ...... n of transcription factor Sp1.
@nl
P2093
P2860
P356
P1476
Triptolide-induced cell death ...... n of transcription factor Sp1.
@en
P2093
Ashok K Saluja
Olivia McGinn
Rohit Chugh
Selwyn M Vickers
Sulagna Banerjee
Veena Sangwan
Vikas Dudeja
P2860
P304
33927-33938
P356
10.1074/JBC.M113.500983
P407
P577
2013-10-15T00:00:00Z