Robust neutralizing antibodies elicited by HIV-1 JRFL envelope glycoprotein trimers in nonhuman primates.
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A Cysteine Zipper Stabilizes a Pre-Fusion F Glycoprotein Vaccine for Respiratory Syncytial VirusVaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding SiteAn efficiently cleaved HIV-1 clade C Env selectively binds to neutralizing antibodiesThermostability of Well-Ordered HIV Spikes Correlates with the Elicitation of Autologous Tier 2 Neutralizing AntibodiesEnvelope variants circulating as initial neutralization breadth developed in two HIV-infected subjects stimulate multiclade neutralizing antibodies in rabbits.Hyperglycosylated stable core immunogens designed to present the CD4 binding site are preferentially recognized by broadly neutralizing antibodies.Well-ordered trimeric HIV-1 subtype B and C soluble spike mimetics generated by negative selection display native-like propertiesIdentification of Non-HIV Immunogens That Bind to Germline b12 Predecessors and Prime for Elicitation of Cross-clade Neutralizing HIV-1 Antibodies.Diverse antibody genetic and recognition properties revealed following HIV-1 envelope glycoprotein immunization.Immunogenic Display of Purified Chemically Cross-Linked HIV-1 Spikes.HIV Envelope Trimer Specific Immune Response Is Influenced by Different Adjuvant Formulations and Heterologous Prime-Boost.Characterization and Implementation of a Diverse Simian Immunodeficiency Virus SIVsm Envelope Panel in the Assessment of Neutralizing Antibody Breadth Elicited in Rhesus Macaques by Multimodal Vaccines Expressing the SIVmac239 Envelope.A New Approach to Produce HIV-1 Envelope Trimers: BOTH CLEAVAGE AND PROPER GLYCOSYLATION ARE ESSENTIAL TO GENERATE AUTHENTIC TRIMERSThe Carbomer-Lecithin Adjuvant Adjuplex Has Potent Immunoactivating Properties and Elicits Protective Adaptive Immunity against Influenza Virus Challenge in Mice.Sequential and Simultaneous Immunization of Rabbits with HIV-1 Envelope Glycoprotein SOSIP.664 Trimers from Clades A, B and C.Effective Respiratory CD8 T-Cell Immunity to Influenza Virus Induced by Intranasal Carbomer-Lecithin-Adjuvanted Non-replicating Vaccines.HIV-1 Vaccine-elicited Antibodies Reverted to Their Inferred Naive Germline Reveal Associations between Binding Affinity and in vivo Activation.Conformational Epitope-Specific Broadly Neutralizing Plasma Antibodies Obtained from an HIV-1 Clade C-Infected Elite Neutralizer Mediate Autologous Virus Escape through Mutations in the V1 Loop.Achieving Potent Autologous Neutralizing Antibody Responses against Tier 2 HIV-1 Viruses by Strategic Selection of Envelope Immunogens.Enhanced antibody-mediated neutralization of HIV-1 variants that are resistant to fusion inhibitors.Native-like Env trimers as a platform for HIV-1 vaccine design.Electroporation-enhanced delivery of nucleic acid vaccines.Breaching peripheral tolerance promotes the production of HIV-1-neutralizing antibodies.Stabilization of a soluble, native-like trimeric form of an efficiently cleaved Indian HIV-1 clade C envelope glycoproteinEvolution of B cell analysis and Env trimer redesign.HIV-1 Cross-reactive Primary Virus Neutralizing Antibody Response Elicited by Immunization in Non-human Primate.Structure-based Design of Cyclically Permuted HIV-1 gp120 Trimers That Elicit Neutralizing Antibodies.Membrane bound modified form of clade B Env, JRCSF is suitable for immunogen design as it is efficiently cleaved and displays all the broadly neutralizing epitopes including V2 and C2 domain-dependent conformational epitopes.An HIV-1 Env-Antibody Complex Focuses Antibody Responses to Conserved Neutralizing Epitopes.Characterization of protective immune response elicited by a trimeric envelope protein from an Indian clade C HIV-1 isolate in rhesus macaques.Influences on the Design and Purification of Soluble, Recombinant Native-Like HIV-1 Envelope Glycoprotein Trimers.Immunosilencing a highly immunogenic protein trimerization domain.Stabilizing the native trimer of HIV-1 Env by destabilizing the heterodimeric interface of the gp41 postfusion six-helix bundle.Virus-Like-Vaccines against HIV.Effects of Adjuvants on HIV-1 Envelope Glycoprotein SOSIP Trimers In Vitro.Rational Design of DNA-Expressed Stabilized Native-Like HIV-1 Envelope Trimers
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Robust neutralizing antibodies elicited by HIV-1 JRFL envelope glycoprotein trimers in nonhuman primates.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 25 September 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Robust neutralizing antibodies ...... trimers in nonhuman primates.
@en
Robust neutralizing antibodies ...... trimers in nonhuman primates.
@nl
type
label
Robust neutralizing antibodies ...... trimers in nonhuman primates.
@en
Robust neutralizing antibodies ...... trimers in nonhuman primates.
@nl
prefLabel
Robust neutralizing antibodies ...... trimers in nonhuman primates.
@en
Robust neutralizing antibodies ...... trimers in nonhuman primates.
@nl
P2093
P2860
P356
P1433
P1476
Robust neutralizing antibodies ...... trimers in nonhuman primates.
@en
P2093
Bimal K Chakrabarti
Celia C Labranche
Gunilla B Karlsson Hedestam
Krisha McKee
Richard T Wyatt
Shailendra Kumar Sharma
P2860
P304
13239-13251
P356
10.1128/JVI.01247-13
P407
P577
2013-09-25T00:00:00Z