A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence.
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The application of tetracyclineregulated gene expression systems in the validation of novel drug targets in Mycobacterium tuberculosisMycobacterial genes essential for the pathogen's survival in the hostNew insights into TB physiology suggest untapped therapeutic opportunitiesTuberculosis vaccines: barriers and prospects on the quest for a transformative toolInactivation of fructose-1,6-bisphosphate aldolase prevents optimal co-catabolism of glycolytic and gluconeogenic carbon substrates in Mycobacterium tuberculosisMycobacterium tuberculosis Thioredoxin Reductase Is Essential for Thiol Redox Homeostasis but Plays a Minor Role in Antioxidant DefenseTrehalose-6-Phosphate-Mediated Toxicity Determines Essentiality of OtsB2 in Mycobacterium tuberculosis In Vitro and in MiceMetabolic Perspectives on PersistenceIdentification of plant-derived natural products as potential inhibitors of the Mycobacterium tuberculosis proteasomeMycobacterial nicotinate mononucleotide adenylyltransferase: structure, mechanism, and implications for drug discovery.Mycobacterium tuberculosis metabolismGenetic Approaches to Facilitate Antibacterial Drug Development.Therapeutic Potential of the Mycobacterium tuberculosis Mycolic Acid Transporter, MmpL3Investigating essential gene function in Mycobacterium tuberculosis using an efficient CRISPR interference system.Validation of CoaBC as a Bactericidal Target in the Coenzyme A Pathway of Mycobacterium tuberculosis.Depleting Mycobacterium tuberculosis of the transcription termination factor Rho causes pervasive transcription and rapid deathPharmacologic considerations in use and development of antituberculosis drugs.Production of recombinant proteins in Mycobacterium smegmatis for structural and functional studies.Phenotypic Heterogeneity, a Phenomenon That May Explain Why Quorum Sensing Does Not Always Result in Truly Homogenous Cell BehaviorDesign, synthesis, and evaluation of substituted nicotinamide adenine dinucleotide (NAD(+)) synthetase inhibitors as potential antitubercular agents.Assessing essentiality of transketolase in Mycobacterium tuberculosis using an inducible protein degradation system.Targeting Phenotypically Tolerant Mycobacterium tuberculosis.Mycobacterium tuberculosis in the Face of Host-Imposed Nutrient Limitation.Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis.Fumarase Deficiency Causes Protein and Metabolite Succination and Intoxicates Mycobacterium tuberculosis.Cloning, expression, purification, crystallization and preliminary X-ray diffraction studies of NAD synthetase from methicillin-resistant Staphylococcus aureus.Resuscitation-promoting factors are cell wall-lytic enzymes with important roles in the germination and growth of Streptomyces coelicolor.Detection of Mycobacterium tuberculosis in latently infected lungs by immunohistochemistry and confocal microscopy.Systems level mapping of metabolic complexity in Mycobacterium tuberculosis to identify high-value drug targets.Promoter mutagenesis for fine-tuning expression of essential genes in Mycobacterium tuberculosis.Tuberculosis: Just the FAQs.Control of biotin biosynthesis in mycobacteria by a pyruvate carboxylase dependent metabolic signal.Hit Generation in TB Drug Discovery: From Genome to Granuloma.Antibacterial drugs: Persisters come under fire.Drug targets in dormant Mycobacterium tuberculosis: can the conquest against tuberculosis become a reality?Targeting protein biotinylation enhances tuberculosis chemotherapy.Gene Enrichment Analysis Reveals Major Regulators of Mycobacterium tuberculosis Gene Expression in Two Models of Antibiotic Tolerance.Construction of conditional knockdown mutants in mycobacteria.Metabolic principles of persistence and pathogenicity in Mycobacterium tuberculosis.Mycobacterium tuberculosis Pst/SenX3-RegX3 Regulates Membrane Vesicle Production Independently of ESX-5 Activity.
P2860
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P2860
A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年学术文章
@wuu
2013年学术文章
@zh-cn
2013年学术文章
@zh-hans
2013年学术文章
@zh-my
2013年学术文章
@zh-sg
2013年學術文章
@yue
2013年學術文章
@zh
2013年學術文章
@zh-hant
name
A genetic strategy to identify ...... prevent bacterial persistence.
@en
A genetic strategy to identify ...... prevent bacterial persistence.
@nl
type
label
A genetic strategy to identify ...... prevent bacterial persistence.
@en
A genetic strategy to identify ...... prevent bacterial persistence.
@nl
prefLabel
A genetic strategy to identify ...... prevent bacterial persistence.
@en
A genetic strategy to identify ...... prevent bacterial persistence.
@nl
P2093
P2860
P356
P1476
A genetic strategy to identify ...... prevent bacterial persistence.
@en
P2093
Courtney C Aldrich
Daniel J Wilson
Dirk Schnappinger
German Rehren
Helena I M Boshoff
Jee-Hyun Kim
Joshua B Wallach
Kathryn M O'Brien
Kyu Y Rhee
Ritu Sharma
P2860
P304
19095-19100
P356
10.1073/PNAS.1315860110
P407
P577
2013-11-04T00:00:00Z