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Serpins flex their muscle: II. Structural insights into target peptidase recognition, polymerization, and transport functionsSerpins flex their muscle: I. Putting the clamps on proteolysis in diverse biological systemsArabidopsis AtSerpin1, crystal structure and in vivo interaction with its target protease RESPONSIVE TO DESICCATION-21 (RD21)Basis for the specificity and activation of the serpin protein Z-dependent proteinase inhibitor (ZPI) as an inhibitor of membrane-associated factor XaHeparin binds lamprey angiotensinogen and promotes thrombin inhibition through a template mechanismA quantitative method for the specific assessment of caspase-6 activity in cell cultureQingfei Xiaoyan Wan alleviates asthma through multi-target network regulationSucrose octasulfate selectively accelerates thrombin inactivation by heparin cofactor IIInhibitory properties of the P1 Tyr variant of antithrombin.Retention of thrombin inhibitory activity by recombinant serpins expressed as integral membrane proteins tethered to the surface of mammalian cells.Characterization of a novel serine protease inhibitor gene from a marine metagenome.Role of the residues of the 39-loop in determining the substrate and inhibitor specificity of factor IXa.Novel scabies mite serpins inhibit the three pathways of the human complement system.Characterisation of a secretory serine protease inhibitor (SjB6) from Schistosoma japonicum.Tsetse GmmSRPN10 has anti-complement activity and is important for successful establishment of trypanosome infections in the fly midgutANISERP: a new serpin from the parasite Anisakis simplex.Polyphosphate elicits pro-inflammatory responses that are counteracted by activated protein C in both cellular and animal models.Investigating changes in the gas-phase conformation of Antithrombin III upon binding of Arixtra using traveling wave ion mobility spectrometry (TWIMS).Identification of serpin determinants of specificity and selectivity for furin inhibition through studies of α1PDX (α1-protease inhibitor Portland)-serpin B8 and furin active-site loop chimerasProprotein convertase subtilisin/kexin type 3 promotes adipose tissue-driven macrophage chemotaxis and is increased in obesity.Three pairs of protease-serpin complexes cooperatively regulate the insect innate immune responses.Molecular mechanisms of antithrombin-heparin regulation of blood clotting proteinases. A paradigm for understanding proteinase regulation by serpin family protein proteinase inhibitors.The plasmin-antiplasmin system: structural and functional aspects.Vaspin (serpinA12) in obesity, insulin resistance, and inflammation.Identification of Serpinb6b as a species-specific mouse granzyme A inhibitor suggests functional divergence between human and mouse granzyme A.Basic Residues of β-Sheet A Contribute to Heparin Binding and Activation of Vaspin (Serpin A12).Inhibitory serpins. New insights into their folding, polymerization, regulation and clearance.Distinct encounter complexes of PAI-1 with plasminogen activators and vitronectin revealed by changes in the conformation and dynamics of the reactive center loop.Role of the P2 residue of human alpha 1-antitrypsin in determining target protease specificity.Extending the cellulosome paradigm: the modular Clostridium thermocellum cellulosomal serpin PinA is a broad-spectrum inhibitor of subtilisin-like proteases.An analysis approach to identify specific functional sites in orthologous proteins using sequence and structural information: application to neuroserpin reveals regions that differentially regulate inhibitory activity.Molecular bases of neuroserpin function and pathology.Identification of serpins specific for activated protein C using a lysate-based screening assay.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 28 April 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Exosite determinants of serpin specificity.
@en
Exosite determinants of serpin specificity.
@nl
type
label
Exosite determinants of serpin specificity.
@en
Exosite determinants of serpin specificity.
@nl
prefLabel
Exosite determinants of serpin specificity.
@en
Exosite determinants of serpin specificity.
@nl
P2860
P356
P1476
Exosite determinants of serpin specificity.
@en
P2093
Peter G W Gettins
Steven T Olson
P2860
P304
20441-20445
P356
10.1074/JBC.R800064200
P407
P577
2009-04-28T00:00:00Z