Plasminogen activator inhibitor-1 regulates integrin alphavbeta3 expression and autocrine transforming growth factor beta signaling. - Wikidata - awgldk - TriplyDB

Plasminogen activator inhibitor-1 regulates integrin alphavbeta3 expression and autocrine transforming growth factor beta signaling.

Plasminogen activator inhibitor-1 regulates integrin alphavbeta3 expression and autocrine transforming growth factor beta signaling.

http://www.wikidata.org/entity/Q37344022

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The role of integrins in TGFβ activation in the tumour stroma Recombinant PAI-1 therapy restores myoendothelial junctions and erectile function in PAI-1-deficient mice.Plasminogen activator inhibitor-1 regulates myoendothelial junction formation.Plasminogen activator inhibitor-1 (PAI-1) is cardioprotective in mice by maintaining microvascular integrity and cardiac architecture.Concentration-dependent effects of transforming growth factor β1 on corneal wound healing.Cigarette smoke exacerbates mouse allergic asthma through Smad proteins expressed in mast cells.Site-specific keloid fibroblasts alter the behaviour of normal skin and normal scar fibroblasts through paracrine signalling.Binding of anti-SSA antibodies to apoptotic fetal cardiocytes stimulates urokinase plasminogen activator (uPA)/uPA receptor-dependent activation of TGF-β and potentiates fibrosis.PAI-1-regulated miR-21 defines a novel age-associated fibrogenic pathway in muscular dystrophy.Chemical Antagonists of Plasminogen Activator Inhibitor-1: Mechanisms of Action and Therapeutic Potential in Vascular Disease.Knock-down of plasminogen-activator inhibitor-1 enhances expression of E-cadherin and promotes epithelial differentiation of human pancreatic adenocarcinoma cells.uPA binding to PAI-1 induces corneal myofibroblast differentiation on vitronectin.PAI-1 in tissue fibrosis.Low Molecular Weight Antagonists of Plasminogen Activator Inhibitor-1: Therapeutic Potential in Cardiovascular Disease Spontaneous massive necrosis of hepatocellular carcinoma with narrowing and occlusion of the arteries and portal veins PAI-1: An Integrator of Cell Signaling and Migration.Plasminogen activator inhibitor type 1 interacts with alpha3 subunit of proteasome and modulates its activity.SERPINE1: A Molecular Switch in the Proliferation-Migration Dichotomy in Wound-"Activated" Keratinocytes 5-HT(2B) antagonism arrests non-canonical TGF-β1-induced valvular myofibroblast differentiation.TM5441, a plasminogen activator inhibitor-1 inhibitor, protects against high fat diet-induced non-alcoholic fatty liver disease.PAI1 mediates fibroblast-mast cell interactions in skin fibrosis.

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Plasminogen activator inhibitor-1 regulates integrin alphavbeta3 expression and autocrine transforming growth factor beta signaling.

http://www.wikidata.org/entity/Q37344022

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on June 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Plasminogen activator inhibito ...... growth factor beta signaling.

@en

Plasminogen activator inhibito ...... growth factor beta signaling.

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type

label

Plasminogen activator inhibito ...... growth factor beta signaling.

@en

Plasminogen activator inhibito ...... growth factor beta signaling.

@nl

prefLabel

Plasminogen activator inhibito ...... growth factor beta signaling.

@en

Plasminogen activator inhibito ...... growth factor beta signaling.

@nl

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JBC.M109.018804

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Journal of Biological Chemistry

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Plasminogen activator inhibito ...... growth factor beta signaling.

@en

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Alex O Imas

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Audrey M Bernstein

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Benjamin S Pedroja

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Leah E Kang

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P2860

Recycling of the urokinase receptor upon internalization of the uPA:serpin complexes

The integrin alphavbeta3 is a receptor for the latency-associated peptides of transforming growth factors beta1 and beta3

Direct binding of occupied urokinase receptor (uPAR) to LDL receptor-related protein is required for endocytosis of uPAR and regulation of cell surface urokinase activity

Cellular and molecular mechanisms of fibrosis

The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1

Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix

The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis

Myofibroblasts and mechano-regulation of connective tissue remodelling

Differential effects of fibroblast growth factors on expression of genes of the plasminogen activator and insulin-like growth factor systems by human breast fibroblasts

uPAR: a versatile signalling orchestrator.

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20708-20717

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scholarly article

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10.1074/JBC.M109.018804

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31

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284

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Peter Carmeliet

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2009-06-01T00:00:00Z

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19487690

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2742836

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