Recombination between antibody heavy chain variable-region genes: evidence for gene conversion
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Ruminant globin gene structures suggest an evolutionary role for Alu-type repeatsRearranged immunoglobulin heavy chain variable region (VH) pseudogene that deletes the second complementarity-determining regionMutation in the CYP21B gene (Ile-172----Asn) causes steroid 21-hydroxylase deficiency.A V region determinant (idiotope) expressed at high frequency in B lymphocytes is encoded by a large set of antibody structural genes.Gene conversions can generate sequence variants in the late chorion multigene families of Bombyx mori.Evidence for two pathways of meiotic intrachromosomal recombination in yeast.Somatic diversification of S107 from an antiphosphocholine to an anti-DNA autoantibody is due to a single base change in its heavy chain variable region.Gene conversion in a cytochrome P-450 gene familyImmunoglobulin gene hyperconversion ongoing in chicken splenic germinal centers.Intergenic exchange maintains identity between two human lambda light chain immunoglobulin gene intron sequencesExpression and rearrangement of homologous immunoglobulin VH genes in two mouse strains.DNA sequence transfer between two high-cysteine chorion gene families in the silkmoth Bombyx mori.Evidence for gene conversion among immunoglobulin heavy chain variable region genesParallel evolution of antibody variable regions by somatic processes: consecutive shared somatic alterations in VH genes expressed by independently generated hybridomas apparently acquired by point mutation and selection rather than by gene conversiA single pre-B cell can give rise to antigen-specific B cells that utilize distinct immunoglobulin gene rearrangements.Point mutations cause the somatic diversification of IgM and IgG2a antiphosphorylcholine antibodies.Interaction and sequence diversity among T15 VH genes in CBA/J mice.Alternative V kappa gene rearrangements in a murine B cell lymphoma. An explantation for idiotypic heterogeneity.Evolution of antibody structure during the immune response. The differentiative potential of a single B lymphocyte.Analysis of a novel VHS107 haplotype in CLA-2 and WSA mice. Evidence for gene conversion among IgVH genes in outbred populations.Functional and pseudogenes are similarly organized and may equally contribute to the extensive antibody diversity of the IgVHII family.Nucleotide sequences of liver, lachrymal, and submaxillary gland mouse major urinary protein mRNAs: mosaic structure and construction of panels of gene-specific synthetic oligonucleotide probes.Heteroduplex deoxyribonucleic acid base mismatch repair in bacteria.Somatic mutation of the T15 heavy chain gives rise to an antibody with autoantibody specificity.Possible involvement of human D minigenes in the first complementarity-determining region of kappa light chains.Silkmoth chorion gene families contain patchwork patterns of sequence homology.Characterization of a new V gene replacement in the absence of activation-induced cytidine deaminase and its contribution to human B-cell receptor diversity.Analysis of immunoglobulin heavy chain V-region genes belonging to the V NP-gene family.Dynamic gene interactions in the evolution of rabbit VH genes: a four codon duplication and block homologies provide evidence for intergenic exchange.Palindromic sequences are associated with sites of DNA breakage during gene conversion.Directed Ig class switch recombination in activated murine B cells.Somatic mutation and clonal expansion of B cells in an antigen-driven immune response.Derivation and diversification of monoclonal antibodies.Members of novel VH gene families are found in VDJ regions of polyclonally activated B-lymphocytes.Somatic generation of hybrid antibody H chain genes in transgenic mice via interchromosomal gene conversion.Idiotypic selection of an antibody mutant with changed hapten binding specificity, resulting from a point mutation in position 50 of the heavy chain.Gene Conversion-Like Events in the Diversification of Human Rearranged IGHV3-23*01 Gene Sequences.Clonal recruitment and somatic mutation in the generation of immunological memory to the hapten NPAntibody engineering for the analysis of affinity maturation of an anti-hapten response.21-hydroxylase genotyping in Australasian patients with congenital adrenal hyperplasia.
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Recombination between antibody heavy chain variable-region genes: evidence for gene conversion
description
article científic
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article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on August 1983
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Recombination between antibody ...... : evidence for gene conversion
@en
Recombination between antibody ...... evidence for gene conversion.
@nl
type
label
Recombination between antibody ...... : evidence for gene conversion
@en
Recombination between antibody ...... evidence for gene conversion.
@nl
prefLabel
Recombination between antibody ...... : evidence for gene conversion
@en
Recombination between antibody ...... evidence for gene conversion.
@nl
P2093
P2860
P356
P1476
Recombination between antibody ...... : evidence for gene conversion
@en
P2093
Brüggemann M
Krawinkel U
Radbruch A
Zoebelein G
P2860
P304
P356
10.1073/PNAS.80.16.4997
P407
P577
1983-08-01T00:00:00Z