Indomethacin amides as a novel molecular scaffold for targeting Trypanosoma cruzi sterol 14alpha-demethylase. - Wikidata - awgldk - TriplyDB

Indomethacin amides as a novel molecular scaffold for targeting Trypanosoma cruzi sterol 14alpha-demethylase.

Indomethacin amides as a novel molecular scaffold for targeting Trypanosoma cruzi sterol 14alpha-demethylase.

http://www.wikidata.org/entity/Q37347145

about

CYP51 structures and structure-based development of novel, pathogen-specific inhibitory scaffolds Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections Bioactive lipids in Trypanosoma cruzi infection Structural Insights into Inhibition of Sterol 14 -Demethylase in the Human Pathogen Trypanosoma cruzi Complexes of Trypanosoma cruzi Sterol 14 -Demethylase (CYP51) with Two Pyridine-based Drug Candidates for Chagas Disease: STRUCTURAL BASIS FOR PATHOGEN SELECTIVITY Structural Basis for Rational Design of Inhibitors Targeting Trypanosoma cruzi Sterol 14α-Demethylase: Two Regions of the Enzyme Molecule Potentiate Its Inhibition Trypanosoma brucei CYP51: Essentiality and Targeting Therapy in an Experimental Model Sterol 14alpha-demethylase (CYP51) as a therapeutic target for human trypanosomiasis and leishmaniasis Aspirin treatment of mice infected with Trypanosoma cruzi and implications for the pathogenesis of Chagas disease Azole binding properties of Candida albicans sterol 14-alpha demethylase (CaCYP51).Resistance to antifungals that target CYP51.Drug strategies targeting CYP51 in neglected tropical diseases Targeting Trypanosoma cruzi sterol 14α-demethylase (CYP51)Azole affinity of sterol 14α-demethylase (CYP51) enzymes from Candida albicans and Homo sapiens.Design or screening of drugs for the treatment of Chagas disease: what shows the most promise?Trypanocidal drugs: mechanisms, resistance and new targets.Podophyllotoxin analogues active versus Trypanosoma brucei.Recent Developments in Sterol 14-demethylase Inhibitors for Chagas Disease.

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P2860

Indomethacin amides as a novel molecular scaffold for targeting Trypanosoma cruzi sterol 14alpha-demethylase.

http://www.wikidata.org/entity/Q37347145

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on May 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

@cs

name

Indomethacin amides as a novel ...... zi sterol 14alpha-demethylase.

@en

Indomethacin amides as a novel ...... zi sterol 14alpha-demethylase.

@nl

type

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Indomethacin amides as a novel ...... zi sterol 14alpha-demethylase.

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Indomethacin amides as a novel ...... zi sterol 14alpha-demethylase.

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prefLabel

Indomethacin amides as a novel ...... zi sterol 14alpha-demethylase.

@en

Indomethacin amides as a novel ...... zi sterol 14alpha-demethylase.

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Journal of Medicinal Chemistry

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Indomethacin amides as a novel ...... zi sterol 14alpha-demethylase.

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P2093

Fernando Villalta

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Galina I Lepesheva

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Jens P von Kries

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Lawrence J Marnett

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Mary E Konkle

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Md Jashim Uddin

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Michael R Waterman

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Richard M Caprioli

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Tatiana Y Hargrove

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W David Nes

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P2860

Induction of resistance to azole drugs in Trypanosoma cruzi.

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Conformational dynamics in the F/G segment of CYP51 from Mycobacterium tuberculosis monitored by FRET.

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Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors.

Non-Michaelis-Menten kinetics in cytochrome P450-catalyzed reactions.

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Quinuclidine derivatives as potential antiparasitics

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scholarly article

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10.1021/JM801643B

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9

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52

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19354253

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2744100

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