Human platelets contain phospholipase C that hydrolyzes polyphosphoinositides.
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The phospholipase C/protein kinase C pathway is involved in cathepsin G-induced human platelet activation: comparison with thrombinAngiotensin II-induced phosphatidylcholine hydrolysis in cultured vascular smooth-muscle cells. Regulation and localizationInositol lipids, phosphatidate and diacylglycerol share stearoylarachidonoylglycerol as a common backbone in thrombin-stimulated human plateletsActivation of phospholipases A and C in human platelets exposed to epinephrine: role of glycoproteins IIb/IIIa and dual role of epinephrine.Modulation of human platelet protein kinase C by endotoxic lipid A.Platelet protein phosphorylation, elevation of cytosolic calcium, and inositol phospholipid breakdown in platelet activation induced by plasminAssociation of gelsolin with actin filaments and cell membranes of macrophages and plateletsLoss of PIP5KIbeta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation.Stimulation of inositide degradation in clumping Stigmatella aurantiaca.Lack of correlation between changes in polyphosphoinositide levels and actin/gelsolin complexes in A431 cells treated with epidermal growth factor.Interferon-gamma-stimulated and GTP-binding-proteins-mediated phospholipase A2 activation in human neuroblasts.Activation of phospholipase C in thrombin-stimulated platelets does not depend on cytoplasmic free calcium concentration.Platelet adenylate cyclase and phospholipase C are affected differentially by ADP-ribosylation. Effects on thrombin-mediated responsesPhosphatidylinositol 3,4,5-trisphosphate is formed from phosphatidylinositol 4,5-bisphosphate in thrombin-stimulated plateletsActivation of human platelet phospholipase C by ionophore A23187 is totally dependent upon cyclo-oxygenase products and ADP.Stimulated cholesterol-enriched platelets display increased cytosolic Ca2+ and phospholipase A activity independent of changes in inositol trisphosphates and agonist/receptor binding.Characterization of partially purified phospholipase C from human platelet membranes.Accumulation of the inositol phosphates in thrombin-stimulated, washed rabbit platelets in the presence of lithium.Effect of pertussis toxin and neomycin on G-protein-regulated polyphosphoinositide phosphodiesterase. A comparison between HL60 membranes and permeabilized HL60 cells.Characterization of multiple forms of phosphoinositide-specific phospholipase C purified from human plateletsIntracellular mechanisms in the activation of human platelets by low-density lipoproteins.Activation of phospholipase C associated with isolated rabbit platelet membranes by guanosine 5'-[gamma-thio]triphosphate and by thrombin in the presence of GTP.Subcellular localization of inositol lipids in blood platelets as deduced from the use of labelled precursors.Chlorphentermine suppresses the phosphatidylinositol pathway in concanavalin A-activated mouse splenic lymphocytes.Mathematical model of PAR1-mediated activation of human platelets.
P2860
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P2860
Human platelets contain phospholipase C that hydrolyzes polyphosphoinositides.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on September 1983
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Human platelets contain phospholipase C that hydrolyzes polyphosphoinositides.
@en
Human platelets contain phospholipase C that hydrolyzes polyphosphoinositides.
@nl
type
label
Human platelets contain phospholipase C that hydrolyzes polyphosphoinositides.
@en
Human platelets contain phospholipase C that hydrolyzes polyphosphoinositides.
@nl
prefLabel
Human platelets contain phospholipase C that hydrolyzes polyphosphoinositides.
@en
Human platelets contain phospholipase C that hydrolyzes polyphosphoinositides.
@nl
P2860
P356
P1476
Human platelets contain phospholipase C that hydrolyzes polyphosphoinositides.
@en
P2093
S E Rittenhouse
P2860
P304
P356
10.1073/PNAS.80.17.5417
P407
P577
1983-09-01T00:00:00Z