Full implementation of the genetic code by tryptophanyl-tRNA synthetase requires intermodular coupling
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Urzymology: experimental access to a key transition in the appearance of enzymesWhat RNA World? Why a Peptide/RNA Partnership Merits Renewed Experimental AttentionFunctional Class I and II Amino Acid-activating Enzymes Can Be Coded by Opposite Strands of the Same GeneThe Rodin-Ohno hypothesis that two enzyme superfamilies descended from one ancestral gene: an unlikely scenario for the origins of translation that will not be dismissed.An Ancestral Tryptophanyl-tRNA Synthetase Precursor Achieves High Catalytic Rate Enhancement without Ordered Ground-State Tertiary Structures.High-Dimensional Mutant and Modular Thermodynamic Cycles, Molecular Switching, and Free Energy Transduction.Augmenting the anisotropic network model with torsional potentials improves PATH performance, enabling detailed comparison with experimental rate data.Enhanced amino acid selection in fully evolved tryptophanyl-tRNA synthetase, relative to its urzyme, requires domain motion sensed by the D1 switch, a remote dynamic packing motif.Combining multi-mutant and modular thermodynamic cycles to measure energetic coupling networks in enzyme catalysis.Overcoming Challenges in Engineering the Genetic CodeRedesigning the stereospecificity of tyrosyl-tRNA synthetase.Determinants for tRNA-dependent pretransfer editing in the synthetic site of isoleucyl-tRNA synthetase.Coding of Class I and II Aminoacyl-tRNA Synthetases.
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Full implementation of the genetic code by tryptophanyl-tRNA synthetase requires intermodular coupling
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 20 October 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Full implementation of the gen ...... requires intermodular coupling
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Full implementation of the gen ...... equires intermodular coupling.
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type
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Full implementation of the gen ...... requires intermodular coupling
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Full implementation of the gen ...... equires intermodular coupling.
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prefLabel
Full implementation of the gen ...... requires intermodular coupling
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Full implementation of the gen ...... equires intermodular coupling.
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P356
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Full implementation of the gen ...... requires intermodular coupling
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Charles W Carter
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P304
34736-34745
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10.1074/JBC.M113.510958
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P577
2013-10-20T00:00:00Z