Repression of the SUMO-specific protease Senp1 induces p53-dependent premature senescence in normal human fibroblasts.
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Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathwaysSUMO-specific protease 2 in Mdm2-mediated regulation of p53A manually curated network of the PML nuclear body interactome reveals an important role for PML-NBs in SUMOylation dynamics.Silencing nuclear pore protein Tpr elicits a senescent-like phenotype in cancer cellsp53 post-translational modification: deregulated in tumorigenesisInhibition of p53 deSUMOylation exacerbates puromycin aminonucleoside-induced apoptosis in podocytes.The transcriptional cofactor MCAF1/ATF7IP is involved in histone gene expression and cellular senescenceLoss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1Primary human cervical carcinoma cells require human papillomavirus E6 and E7 expression for ongoing proliferation.Aberrant sumoylation signaling evoked by reactive oxygen species impairs protective function of Prdx6 by destabilization and repression of its transcription.Mutations in the GM1 binding site of simian virus 40 VP1 alter receptor usage and cell tropism.SUMO deconjugation is required for arsenic-triggered ubiquitylation of PMLThe bacterial genotoxin colibactin promotes colon tumor growth by modifying the tumor microenvironmentSPOP E3 Ubiquitin Ligase Adaptor Promotes Cellular Senescence by Degrading the SENP7 deSUMOylasePML, SUMOylation, and SenescenceLoss of p53 causes mitochondrial DNA depletion and altered mitochondrial reactive oxygen species homeostasis.SENP1 Is a Crucial Regulator for Cell Senescence through DeSUMOylation of Bmi1.Oxidative stress-induced assembly of PML nuclear bodies controls sumoylation of partner proteins.Deubiquitylating enzymes and DNA damage response pathways.KSHV latent protein LANA2 inhibits sumo2 modification of p53.SUMO and the robustness of cancer.NFBD1/MDC1 regulates Cav1 and Cav2 independently of DNA damage and p53.Chronic stress induces ageing-associated degeneration in rat Leydig cells.Desumoylase SENP6 maintains osteochondroprogenitor homeostasis by suppressing the p53 pathway.Quantitative SUMO proteomics reveals the modulation of several PML nuclear body associated proteins and an anti-senescence function of UBC9.
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Repression of the SUMO-specific protease Senp1 induces p53-dependent premature senescence in normal human fibroblasts.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 24 July 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Repression of the SUMO-specifi ...... e in normal human fibroblasts.
@en
Repression of the SUMO-specifi ...... e in normal human fibroblasts.
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type
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Repression of the SUMO-specifi ...... e in normal human fibroblasts.
@en
Repression of the SUMO-specifi ...... e in normal human fibroblasts.
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prefLabel
Repression of the SUMO-specifi ...... e in normal human fibroblasts.
@en
Repression of the SUMO-specifi ...... e in normal human fibroblasts.
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P2093
P2860
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Repression of the SUMO-specifi ...... e in normal human fibroblasts.
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Daniel DiMaio
Gregory A Korbel
Igor B Roninson
Kristin E Yates
Michael Shtutman
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P304
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10.1111/J.1474-9726.2008.00411.X
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2008-07-24T00:00:00Z