Pharmacological characterization of 2-methoxy-N-propylnorapomorphine's interactions with D2 and D3 dopamine receptors.
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PAOPA, a potent analogue of Pro-Leu-glycinamide and allosteric modulator of the dopamine D2 receptor, prevents NMDA receptor antagonist (MK-801)-induced deficits in social interaction in the rat: implications for the treatment of negative symptoms iOccupancy of dopamine D₂ and D₃ and serotonin 5-HT₁A receptors by the novel antipsychotic drug candidate, cariprazine (RGH-188), in monkey brain measured using positron emission tomographyAll Roads to Schizophrenia Lead to Dopamine Supersensitivity and Elevated Dopamine D2High ReceptorsDopamine beta-hydroxylase-deficient mice have normal densities of D(2) dopamine receptors in the high-affinity state based on in vivo PET imaging and in vitro radioligand binding.Synthesis and Evaluation of Fluorinated Aporphines: Potential Positron Emission Tomography Ligands for D2 ReceptorsImaging the high-affinity state of the dopamine D2 receptor in vivo: fact or fiction?Arrestin3 mediates D(2) dopamine receptor internalization.Modulation of Synaptic Plasticity in the Cortex Needs to Understand All the Players.Absolute abundances and affinity states of dopamine receptors in mammalian brain: A review.Clozapine, atypical antipsychotics, and the benefits of fast-off D2 dopamine receptor antagonism.Agonist high- and low-affinity states of dopamine D₂ receptors: methods of detection and clinical implications.Advances and challenges in the search for D2 and D3 dopamine receptor-selective compounds.[3H]4-(dimethylamino)-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl) butyl)benzamide: a selective radioligand for dopamine D(3) receptors. II. Quantitative analysis of dopamine D(3) and D(2) receptor density ratio in the caudate-putamen.Agonist signalling properties of radiotracers used for imaging of dopamine D2/3 receptors.[(3)H]4-(Dimethylamino)-N-[4-(4-(2-methoxyphenyl)piperazin- 1-yl)butyl]benzamide, a selective radioligand for dopamine D(3) receptors. I. In vitro characterizationConvenient synthesis of 18F-radiolabeled R-(-)-N-n-propyl-2-(3-fluoropropanoxy-11-hydroxynoraporphine.Test-retest reproducibility of dopamine D2/3 receptor binding in human brain measured by PET with [11C]MNPA and [11C]raclopride.Affinity States of Striatal Dopamine D2 Receptors in Antipsychotic-Free Patients with Schizophrenia.Dopamine agonist radioligand binds to both D2High and D2Low receptors, explaining why alterations in D2High are not detected in human brain scans.
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P2860
Pharmacological characterization of 2-methoxy-N-propylnorapomorphine's interactions with D2 and D3 dopamine receptors.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on June 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Pharmacological characterizati ...... D2 and D3 dopamine receptors.
@en
Pharmacological characterizati ...... D2 and D3 dopamine receptors.
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type
label
Pharmacological characterizati ...... D2 and D3 dopamine receptors.
@en
Pharmacological characterizati ...... D2 and D3 dopamine receptors.
@nl
prefLabel
Pharmacological characterizati ...... D2 and D3 dopamine receptors.
@en
Pharmacological characterizati ...... D2 and D3 dopamine receptors.
@nl
P2093
P2860
P356
P1433
P1476
Pharmacological characterizati ...... D2 and D3 dopamine receptors.
@en
P2093
David R Sibley
Mette Skinbjerg
Robert B Innis
Yoon Namkung
P2860
P304
P356
10.1002/SYN.20626
P577
2009-06-01T00:00:00Z