Mechanism of IAPP amyloid fibril formation involves an intermediate with a transient β-sheet. - Wikidata - awgldk - TriplyDB

Mechanism of IAPP amyloid fibril formation involves an intermediate with a transient β-sheet.

Mechanism of IAPP amyloid fibril formation involves an intermediate with a transient β-sheet.

http://www.wikidata.org/entity/Q37353196

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Site-specific infrared probes of proteins Inter-species cross-seeding: stability and assembly of rat-human amylin aggregates Secondary Structure of Rat and Human Amylin across Force Fields Structural Characterization of Fibrils from Recombinant Human Islet Amyloid Polypeptide by Solid-State NMR: The Central FGAILS Segment Is Part of the β-Sheet Core Spatially Resolved Two-Dimensional Infrared Spectroscopy via Wide-Field Microscopy Watching Proteins Wiggle: Mapping Structures with Two-Dimensional Infrared Spectroscopy.Protein structural and surface water rearrangement constitute major events in the earliest aggregation stages of tau.Analysis of the Amyloidogenic Potential of Pufferfish (Takifugu rubripes) Islet Amyloid Polypeptide Highlights the Limitations of Thioflavin-T Assays and the Difficulties in Defining Amyloidogenicity Disordered amyloidogenic peptides may insert into the membrane and assemble into common cyclic structural motifs.Rationally designed, nontoxic, nonamyloidogenic analogues of human islet amyloid polypeptide with improved solubility Looked at life from both sides now Two-dimensional sum-frequency generation (2D SFG) spectroscopy: summary of principles and its application to amyloid fiber monolayers.Myeloperoxidase-mediated Methionine Oxidation Promotes an Amyloidogenic Outcome for Apolipoprotein A-I.Applications of two-dimensional infrared spectroscopy X-ray Crystallographic Structures of Oligomers of Peptides Derived from β2-Microglobulin Insights into the consequences of co-polymerisation in the early stages of IAPP and Aβ peptide assembly from mass spectrometry.Analysis of the ability of pramlintide to inhibit amyloid formation by human islet amyloid polypeptide reveals a balance between optimal recognition and reduced amyloidogenicity.Islet Amyloid Polypeptide: Structure, Function, and Pathophysiology.Matrix Metalloproteinase-9 Protects Islets from Amyloid-induced Toxicity Mechanism of Inhibition of Human Islet Amyloid Polypeptide-Induced Membrane Damage by a Small Organic Fluorogen.Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics.Conformational Ensemble of hIAPP Dimer: Insight into the Molecular Mechanism by which a Green Tea Extract inhibits hIAPP Aggregation.Effect of Post-Translational Amidation on Islet Amyloid Polypeptide Conformational Ensemble: Implications for Its Aggregation Early Steps.Polymorphism of oligomers of a peptide from β-amyloid.Not All β-Sheets Are the Same: Amyloid Infrared Spectra, Transition Dipole Strengths, and Couplings Investigated by 2D IR Spectroscopy.An Account of Amyloid Oligomers: Facts and Figures Obtained from Experiments and Simulations.Inhibition of islet amyloid polypeptide aggregation and associated cytotoxicity by nonsteroidal anti-inflammatory drugs.Heparan Sulfate Proteoglycans Are Important for Islet Amyloid Formation and Islet Amyloid Polypeptide-induced Apoptosis.Islet inflammation in type 2 diabetes and physiology.An infrared spectroscopy approach to follow β-sheet formation in peptide amyloid assemblies.Catching protein structural dynamics by two-dimensional infrared spectroscopy.Molecular dynamics simulations of early steps in RNA-mediated conversion of prions.β-Hairpin of Islet Amyloid Polypeptide Bound to an Aggregation Inhibitor Structural Properties of Human IAPP Dimer in Membrane Environment Studied by All-Atom Molecular Dynamics Simulations.Assembly of Peptides Derived from β-Sheet Regions of β-Amyloid.Coassembly of Peptides Derived from β-Sheet Regions of β-Amyloid Sequence-Dependent Self-Assembly and Structural Diversity of Islet Amyloid Polypeptide-Derived β-Sheet Fibrils.Understanding co-polymerization in amyloid formation by direct observation of mixed oligomers.How to Get Insight into Amyloid Structure and Formation from Infrared Spectroscopy.Conformational Ensembles of the Wild-Type and S8C Aβ1-42 Dimers.

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Mechanism of IAPP amyloid fibril formation involves an intermediate with a transient β-sheet.

http://www.wikidata.org/entity/Q37353196

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2013 nî lūn-bûn

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name

Mechanism of IAPP amyloid fibr ...... iate with a transient β-sheet.

@en

Mechanism of IAPP amyloid fibr ...... iate with a transient β-sheet.

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type

label

Mechanism of IAPP amyloid fibr ...... iate with a transient β-sheet.

@en

Mechanism of IAPP amyloid fibr ...... iate with a transient β-sheet.

@nl

prefLabel

Mechanism of IAPP amyloid fibr ...... iate with a transient β-sheet.

@en

Mechanism of IAPP amyloid fibr ...... iate with a transient β-sheet.

@nl

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Proceedings of the National Academy of Sciences of the United States of America

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Mechanism of IAPP amyloid fibr ...... iate with a transient β-sheet.

@en

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Chi-Cheng Chiu

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Emily B Dunkelberger

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James S Nowick

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Juan J de Pablo

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Martin T Zanni

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Pin-Nan Cheng

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Ping Cao

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P2860

Atomic structures of amyloid cross-beta spines reveal varied steric zippers

Atomic structure of the cross-β spine of islet amyloid polypeptide (amylin)

Amyloid β-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity

Atomic View of a Toxic Amyloid Small Oligomer

Protein misfolding, functional amyloid, and human disease

Formation of partially ordered oligomers of amyloidogenic hexapeptide (NFGAIL) in aqueous solution observed in molecular dynamics simulations.

Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

Residue-specific structural kinetics of proteins through the union of isotope labeling, mid-IR pulse shaping, and coherent 2D IR spectroscopy.

Toxic fibrillar oligomers of amyloid-β have cross-β structure.

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19285-19290

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10.1073/PNAS.1314481110

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48

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110

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Daniel P Raleigh

Lauren E. Buchanan

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2013-11-11T00:00:00Z

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24218609

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3845187

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