Transendothelial insulin transport is not saturable in vivo. No evidence for a receptor-mediated process.
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The artificial pancreas: is it important to understand how the β cell controls blood glucose?The barrier within: endothelial transport of hormonesCaveolin-1 phosphorylation regulates vascular endothelial insulin uptake and is impaired by insulin resistance in ratsClosed-loop insulin delivery utilizing pole placement to compensate for delays in subcutaneous insulin deliveryInsulin regulates its own delivery to skeletal muscle by feed-forward actions on the vasculature.Insulin entry into muscle involves a saturable process in the vascular endothelium.Caveolin-1 is required for vascular endothelial insulin uptake.The vascular actions of insulin control its delivery to muscle and regulate the rate-limiting step in skeletal muscle insulin actionImpaired microvascular perfusion: a consequence of vascular dysfunction and a potential cause of insulin resistance in muscle.The vascular endothelial cell mediates insulin transport into skeletal muscle.Central role of the adipocyte in the metabolic syndrome.Central role of the adipocyte in insulin resistance.Portal glucose infusion-glucose clamp measures hepatic influence on postprandial systemic glucose appearance as well as whole body glucose disposal.The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance.The identification of insulin saturation effects during the dynamic insulin sensitivity test.Blood flow and muscle metabolism: a focus on insulin action.Clathrin-dependent entry and vesicle-mediated exocytosis define insulin transcytosis across microvascular endothelial cells.The role of blood vessels, endothelial cells, and vascular pericytes in insulin secretion and peripheral insulin action.Elevated nocturnal NEFA are an early signal for hyperinsulinaemic compensation during diet-induced insulin resistance in dogs.The endothelium in diabetes: its role in insulin access and diabetic complicationsExenatide can reduce glucose independent of islet hormones or gastric emptying.Exenatide sensitizes insulin-mediated whole-body glucose disposal and promotes uptake of exogenous glucose by the liver.Pharmacokinetics and safety in rhesus monkeys of a monoclonal antibody-GDNF fusion protein for targeted blood-brain barrier delivery.Mechanisms of insulin resistance in experimental hyperinsulinemic dogs.Brain insulin signaling: a key component of cognitive processes and a potential basis for cognitive impairment in type 2 diabetes.The role of endothelial insulin signaling in the regulation of glucose metabolism.Skeletal Muscle Vascular Function: A Counterbalance of Insulin Action.Tissue barriers and novel approaches to achieve hepatoselectivity of subcutaneously-injected insulin therapeutics.Endothelial Transcytosis of Insulin: Does It Contribute to Insulin Resistance?Subcutaneous glucose predicts plasma glucose independent of insulin: implications for continuous monitoring.Angiotensin II Inhibits Insulin Binding to Endothelial Cells.The vascular endothelium, a benign restrictive barrier? NO! Role of nitric oxide in regulating insulin action.Hemodynamic actions of insulin: beyond the endothelium.Exogenously imposed postprandial-like rises in systemic glucose and GLP-1 do not produce an incretin effect, suggesting an indirect mechanism of GLP-1 action.Involuntary leg movements affect interstitial nutrient gradients and blood flow in rat skeletal muscle.Prolonged local forearm hyperinsulinemia induces sustained enhancement of nitric oxide-dependent vasodilation in healthy subjects.Insulin exits skeletal muscle capillaries by fluid-phase transport.Endothelial insulin receptors differentially control insulin signaling kinetics in peripheral tissues and brain of mice.The cell biology of systemic insulin function.Endothelial insulin resistance protects the heart against prolonged ischemia-reperfusion injury but does not prevent insulin transport across the endothelium in a mouse Langendorff model.
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P2860
Transendothelial insulin transport is not saturable in vivo. No evidence for a receptor-mediated process.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on March 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Transendothelial insulin trans ...... r a receptor-mediated process.
@en
Transendothelial insulin trans ...... r a receptor-mediated process.
@nl
type
label
Transendothelial insulin trans ...... r a receptor-mediated process.
@en
Transendothelial insulin trans ...... r a receptor-mediated process.
@nl
prefLabel
Transendothelial insulin trans ...... r a receptor-mediated process.
@en
Transendothelial insulin trans ...... r a receptor-mediated process.
@nl
P2093
P2860
P356
P1476
Transendothelial insulin trans ...... r a receptor-mediated process.
@en
P2093
P2860
P304
P356
10.1172/JCI118572
P407
P577
1996-03-01T00:00:00Z