Altered SDF-1/CXCR4 axis in patients with primary myelofibrosis and in the Gata1 low mouse model of the disease. - Wikidata - awgldk - TriplyDB

Altered SDF-1/CXCR4 axis in patients with primary myelofibrosis and in the Gata1 low mouse model of the disease.

Altered SDF-1/CXCR4 axis in patients with primary myelofibrosis and in the Gata1 low mouse model of the disease.

http://www.wikidata.org/entity/Q37353939

about

Abnormal P-selectin localization during megakaryocyte development determines thrombosis in the gata1low model of myelofibrosis Pathological interactions between hematopoietic stem cells and their niche revealed by mouse models of primary myelofibrosis.Evidence for organ-specific stem cell microenvironments Stem cells and bone diseases: new tools, new perspective Whole blood transcriptional profiling reveals deregulation of oxidative and antioxidative defence genes in myelofibrosis and related neoplasms. Potential implications of downregulation of Nrf2 for genomic instability and disease progression.C-X-C motif chemokine 12 influences the development of extramedullary hematopoiesis in the spleens of myelofibrosis patients.Increased differentiation of dermal mast cells in mice lacking the Mpl gene.Inhibition of the CXCL12/CXCR4 chemokine axis with AMD3100, a CXCR4 small molecule inhibitor, worsens murine hepatic injury.CD133 marks a stem cell population that drives human primary myelofibrosis.Splenic extramedullary hematopoietic proliferation in Philadelphia chromosome-negative myeloproliferative neoplasms: heterogeneous morphology and cytological composition.Characterization of the TGF-β1 signaling abnormalities in the Gata1low mouse model of myelofibrosis.CXCR4-independent rescue of the myeloproliferative defect of the Gata1low myelofibrosis mouse model by Aplidin.Gata1 expression driven by the alternative HS2 enhancer in the spleen rescues the hematopoietic failure induced by the hypomorphic Gata1low mutation The bone marrow stroma in hematological neoplasms--a guilty bystander.Rational therapeutic options for patients with myeloproliferative neoplasms.Preclinical models for drug selection in myeloproliferative neoplasms.Extramedullary hematopoiesis (EMH) in laboratory animals: offering an insight into stem cell research.Splenic pooling and loss of VCAM-1 causes an engraftment defect in patients with myelofibrosis after allogeneic hematopoietic stem cell transplantation.Crucial factors of the inflammatory microenvironment (IL-1β/TNF-α/TIMP-1) promote the maintenance of the malignant hemopoietic clone of myelofibrosis: an in vitro study.The thrombopoietin/MPL axis is activated in the Gata1low mouse model of myelofibrosis and is associated with a defective RPS14 signature.CXCL12/CXCR4 pathway is activated by oncogenic JAK2 in a PI3K-dependent manner Haematopoietic focal adhesion kinase deficiency alters haematopoietic homeostasis to drive tumour metastasis.GATA1 insufficiencies in primary myelofibrosis and other hematopoietic disorders: consequences for therapy.Understanding Splenomegaly in Myelofibrosis: Association with Molecular Pathogenesis.Understanding deregulated cellular and molecular dynamics in the haematopoietic stem cell niche to develop novel therapeutics for bone marrow fibrosis.

P2860

Q33711653-B100264A-E7E2-49D4-A4EA-DB8FDFC95395 Q33753094-E1004D3A-F9B2-492E-9A7B-E67967CC1E1E Q33915577-55160406-D0D9-4DB1-A6B7-FEDB541F4426 Q33925049-B8E58D5B-953F-47E5-85AE-94C8B919694F Q34514329-F5749FDF-A284-4F4C-9277-CAE3ED38F21E Q35071450-0A77E1CA-DF0E-4037-88D8-C1B4A4FCCC0D Q35101887-DBFCBB9A-0AE9-4026-AB30-282F002C2244 Q35132609-BB86D8DF-DAF3-4832-9E11-230955860223 Q35669866-C9F5E0AB-FAA3-4263-9256-50F7EA598D54 Q36784523-D158CD2C-2BC9-44D4-97E7-F7622ACB2238 Q36797253-05E5CD14-1E44-420B-B1D2-6E87B50064EB Q37191213-40DFFE58-8071-4F29-9696-1EC6C4FC15EB Q37348257-3378FCC0-4D14-457C-BCB5-939909C4BDD3 Q37859253-9A918A18-5A36-4FB6-9FFD-DAA1F37E25F1 Q37891692-289AE879-8C2C-43DA-AC43-148C7486E84C Q38154517-A4E9BC68-EE07-4620-98ED-59B9EA21E241 Q38342415-C30645D1-F395-4EF5-8D19-A0FBC58E3E58 Q39357992-B05632FD-7E83-49BE-AB07-32073E6CFD31 Q39986585-3B4098F7-1442-4219-BABD-001362A0B838 Q41080088-0B2F7715-D51D-4257-90DC-23BCFF55CF7A Q41553248-3A935254-416A-4BE3-A004-8D30A6FA64B7 Q47806801-5BDE49B5-6D2F-4964-8070-F33E5E22EE0E Q50201003-ADBFFFCD-289A-41E3-856A-DB1B8F7927CD Q51737052-B2E371F6-F981-4107-8C5E-52650FD2B0DB Q52640385-B2F78B35-AAB3-4942-B93D-3BE16A1C8637

P2860

Altered SDF-1/CXCR4 axis in patients with primary myelofibrosis and in the Gata1 low mouse model of the disease.

http://www.wikidata.org/entity/Q37353939

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on February 2008

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Altered SDF-1/CXCR4 axis in pa ...... ow mouse model of the disease.

@en

Altered SDF-1/CXCR4 axis in pa ...... ow mouse model of the disease.

@nl

type

label

Altered SDF-1/CXCR4 axis in pa ...... ow mouse model of the disease.

@en

Altered SDF-1/CXCR4 axis in pa ...... ow mouse model of the disease.

@nl

prefLabel

Altered SDF-1/CXCR4 axis in pa ...... ow mouse model of the disease.

@en

Altered SDF-1/CXCR4 axis in pa ...... ow mouse model of the disease.

@nl

P1433

Q37353939-1835E1E3-68A9-4AFF-BFFF-F2B983CFA27B

P1476

Q37353939-03B2CD58-87D5-4F7B-ABB0-F6B26B311118

P2093

Q37353939-300FFFE1-C9F2-48B6-BC14-9EDA51DA6215

Q37353939-360970C1-C260-403B-A2E6-D10800DC5EA3

Q37353939-415B349F-3B20-45EF-9A39-2876DC36020F

Q37353939-5429DBAD-4063-4B2B-98BA-B69146560574

Q37353939-7FAC89C6-6A62-47E4-AACB-FF9EE8B611ED

Q37353939-818E0D0E-C181-412F-878A-A83BDBCB5274

Q37353939-8CAF565E-98A6-479E-B99E-A2C97DEE61CD

Q37353939-9AD669C3-89BB-400B-9DC2-2DCF0715C2DD

Q37353939-A1B8E828-597D-41A1-9105-5A3180EBBA59

Q37353939-A9B21FA0-70EE-4921-A3C0-D23E036C03F1

P2860

Q37353939-006703A9-0014-4271-99D0-51E97C6CFE47

Q37353939-043068E8-B186-4282-AD29-16EBE2AE5F42

Q37353939-0B5E12C7-9D36-4A32-9DC2-20C7B1912529

Q37353939-0E215301-8B94-4F9E-9DE2-00C72B10D022

Q37353939-0F97C7B2-CCA5-4B76-B295-7E4CF280F6D6

Q37353939-17A9928E-2978-41AE-899D-56D2C5077A41

Q37353939-18AE60CA-349F-439F-8BFE-06C564BE811F

Q37353939-1F10C622-74EF-40F1-A12F-DE12A7C929C3

Q37353939-2A461BCD-8055-4A8F-9991-CBBD4DF215B3

Q37353939-2C8F75EB-19E9-4108-BF4F-B5F87E0FEA42

P304

Q37353939-FC252BF1-0959-4AF1-AAA0-528D0F239341

P31

Q37353939-C414FE46-991F-4571-8332-49AA72F487A9

P356

Q37353939-3A9FC5B2-F329-4C63-8068-E8DA78CB7238

P433

Q37353939-378B2B42-9C1D-45D4-934A-1EF3DC19A6D6

P478

Q37353939-2213332A-9A7A-4481-ACB7-D509DABA9063

P577

Q37353939-DC9614C3-A0AE-45E0-A78C-115FC567452C

P5875

Q37353939-60DFF040-BAC6-4687-A09B-DA8C45CB27D0

P698

Q37353939-D3007367-3FD3-435D-A0FD-BC3FCB7D91A6

P921

Q37353939-ED4C9248-E5CB-42D7-8CDF-FAA760A72D35

P932

Q37353939-C59C0314-4978-4110-9AFE-E57CED8D1BA6

P356

J.EXPHEM.2007.10.001

P1433

Experimental Hematology

P1476

Altered SDF-1/CXCR4 axis in pa ...... ow mouse model of the disease.

@en

P2093

Alessandro Maria Vannucchi

http://www.w3.org/2001/XMLSchema#string

Anna Rita Migliaccio

http://www.w3.org/2001/XMLSchema#string

Betty Nakamoto

http://www.w3.org/2001/XMLSchema#string

Fabrizio Martelli

http://www.w3.org/2001/XMLSchema#string

Giovanni Migliaccio

http://www.w3.org/2001/XMLSchema#string

Hongyu Ni

http://www.w3.org/2001/XMLSchema#string

Maria Verrucci

http://www.w3.org/2001/XMLSchema#string

Mingjiang Xu

http://www.w3.org/2001/XMLSchema#string

Ronald Hoffman

http://www.w3.org/2001/XMLSchema#string

Thalia Papayannopoulou

http://www.w3.org/2001/XMLSchema#string

P2860

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

Megakaryocyte-osteoblast interaction revealed in mice deficient in transcription factors GATA-1 and NF-E2

Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

Osteoblastic cells regulate the haematopoietic stem cell niche

A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches

Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders

Mouse hematopoietic stem-cell antigen Sca-1 is a member of the Ly-6 antigen family

Rapid inactivation of stromal cell-derived factor-1 by cathepsin G associated with lymphocytes.

P304

158-171

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1016/J.EXPHEM.2007.10.001

http://www.w3.org/2001/XMLSchema#string

P433

2

http://www.w3.org/2001/XMLSchema#string

P478

36

http://www.w3.org/2001/XMLSchema#string

P577

2008-02-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

5644420

http://www.w3.org/2001/XMLSchema#string

P698

18206727

http://www.w3.org/2001/XMLSchema#string

P921

P932

2747096

http://www.w3.org/2001/XMLSchema#string