A neuronal cell-based botulinum neurotoxin assay for highly sensitive and specific detection of neutralizing serum antibodies.
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Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based AssaysSelection and characterization of a human monoclonal neutralizing antibody for Clostridium Botulinum neurotoxin serotype BBenzylidene cyclopentenediones: First irreversible inhibitors against botulinum neurotoxin A's zinc endopeptidase.Toosendanin: synthesis of the AB-ring and investigations of its anti-botulinum properties (Part II).Sensitive and quantitative detection of botulinum neurotoxin in neurons derived from mouse embryonic stem cells.Botulinum neurotoxin subtype A2 enters neuronal cells faster than subtype A1Holotoxin Activity of Botulinum Neurotoxin Subtype A4 Originating from a Nontoxigenic Clostridium botulinum Expression System.Neuronal targeting, internalization, and biological activity of a recombinant atoxic derivative of botulinum neurotoxin A.Embryonic stem cell-derived motoneurons provide a highly sensitive cell culture model for botulinum neurotoxin studies, with implications for high-throughput drug discoverySynthesis/biological evaluation of hydroxamic acids and their prodrugs as inhibitors for Botulinum neurotoxin A light chain.Persistence of botulinum neurotoxin a subtypes 1-5 in primary rat spinal cord cellsRapid immune responses to a botulinum neurotoxin Hc subunit vaccine through in vivo targeting to antigen-presenting cells.Analysis of gene expression in induced pluripotent stem cell-derived human neurons exposed to botulinum neurotoxin A subtype 1 and a type A atoxic derivativeSRC family kinase inhibitors antagonize the toxicity of multiple serotypes of botulinum neurotoxin in human embryonic stem cell-derived motor neuronsActivity of botulinum neurotoxin type D (strain 1873) in human neurons.Botulinum Neurotoxins Can Enter Cultured Neurons Independent of Synaptic Vesicle RecyclingRecent developments in cell-based assays and stem cell technologies for botulinum neurotoxin research and drug discoveryNovel application of human neurons derived from induced pluripotent stem cells for highly sensitive botulinum neurotoxin detectionHuman Induced Pluripotent Stem Cell Derived Neuronal Cells Cultured on Chemically-Defined Hydrogels for Sensitive In Vitro Detection of Botulinum Neurotoxin.Model for studying Clostridium botulinum neurotoxin using differentiated motor neuron-like NG108-15 cellsA Novel Botulinum Neurotoxin, Previously Reported as Serotype H, Has a Hybrid-Like Structure With Regions of Similarity to the Structures of Serotypes A and F and Is Neutralized With Serotype A AntitoxinProgress in cell based assays for botulinum neurotoxin detectionPurification and Characterization of Botulinum Neurotoxin FA from a Genetically Modified Clostridium botulinum Strain.Bimodal modulation of the botulinum neurotoxin protein-conducting channelCharacterization of botulinum neurotoxin A subtypes 1 through 5 by investigation of activities in mice, in neuronal cell cultures, and in vitro.Targeting botulinum A cellular toxicity: a prodrug approach.SiMa Cells for a Serotype Specific and Sensitive Cell-Based Neutralization Test for Botulinum Toxin A and E.Development of an Innovative in Vitro Potency Assay for Anti-Botulinum Antitoxins.Botulinum Neurotoxins: Biology, Pharmacology, and Toxicology.Botulinum toxin suppression of CNS network activity in vitro.Enhancing toxin-based vaccines against botulism.Substrate cleavage and duration of action of botulinum neurotoxin type FA ("H, HA").New Steroidal 4-Aminoquinolines Antagonize Botulinum Neurotoxin Serotype A in Mouse Embryonic Stem Cell Derived Motor Neurons in Post-intoxication Model.The Light Chain Defines the Duration of Action of Botulinum Toxin Serotype A Subtypes.Assessment of ELISA as endpoint in neuronal cell-based assay for BoNT detection using hiPSC derived neurons.Neurotransmitter vesicle release from human model neurons (NT2) is sensitive to botulinum toxin A.
P2860
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P2860
A neuronal cell-based botulinum neurotoxin assay for highly sensitive and specific detection of neutralizing serum antibodies.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 12 September 2007
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A neuronal cell-based botulinu ...... neutralizing serum antibodies.
@en
A neuronal cell-based botulinu ...... neutralizing serum antibodies.
@nl
type
label
A neuronal cell-based botulinu ...... neutralizing serum antibodies.
@en
A neuronal cell-based botulinu ...... neutralizing serum antibodies.
@nl
prefLabel
A neuronal cell-based botulinu ...... neutralizing serum antibodies.
@en
A neuronal cell-based botulinu ...... neutralizing serum antibodies.
@nl
P2093
P2860
P1433
P1476
A neuronal cell-based botulinu ...... neutralizing serum antibodies.
@en
P2093
Colin M Clancy
Eric A Johnson
Gary E Borodic
Sabine Pellett
William H Tepp
P2860
P304
P356
10.1016/J.FEBSLET.2007.08.078
P407
P577
2007-09-12T00:00:00Z