COG1410 improves cognitive performance and reduces cortical neuronal loss in the traumatically injured brain
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Inconsistencies and controversies surrounding the amyloid hypothesis of Alzheimer's diseaseApolipoprotein E COG 133 mimetic peptide improves 5-fluorouracil-induced intestinal mucositis.Neuroprotective pentapeptide CN-105 is associated with reduced sterile inflammation and improved functional outcomes in a traumatic brain injury murine model.The apoE-mimetic peptide, COG1410, improves functional recovery in a murine model of intracerebral hemorrhage.COG1410, an apolipoprotein E-based peptide, improves cognitive performance and reduces cortical loss following moderate fluid percussion injury in the rat.Evidence that an APOE ε4 'double whammy' increases risk for Alzheimer's disease.Preclinical efficacy testing in middle-aged rats: nicotinamide, a novel neuroprotectant, demonstrates diminished preclinical efficacy after controlled cortical impact.The effects of a high-fat sucrose diet on functional outcome following cortical contusion injury in the rat.A Combination Therapy of Nicotinamide and Progesterone Improves Functional Recovery following Traumatic Brain Injury.A behavioral and histological comparison of fluid percussion injury and controlled cortical impact injury to the rat sensorimotor cortexAdministration of COG1410 reduces axonal amyloid precursor protein immunoreactivity and microglial activation after controlled cortical impact in mice.A comparison of the effects of nicotinamide and progesterone on functional recovery of cognitive behavior following cortical contusion injury in the rat.Apolipoprotein E-Mimetic COG1410 Reduces Acute Vasogenic Edema following Traumatic Brain Injury.Comparison of the effects of erythropoietin and anakinra on functional recovery and gene expression in a traumatic brain injury model.Administration of S-nitrosoglutathione after traumatic brain injury protects the neurovascular unit and reduces secondary injury in a rat model of controlled cortical impact.Apolipoprotein E mimetic peptide, CN-105, improves outcomes in ischemic stroke.Peptide Pharmacological Approaches to Treating Traumatic Brain Injury: a Case for Arginine-Rich Peptides.Proteomic and functional annotation analysis of injured peripheral nerves reveals ApoE as a protein upregulated by injury that is modulated by metformin treatment.Neuroprotective pentapeptide CN-105 improves functional and histological outcomes in a murine model of intracerebral hemorrhageAssessment of R18, COG1410, and APP96-110 in Excitotoxicity and Traumatic Brain Injury.Apolipoprotein E as a novel therapeutic neuroprotection target after traumatic spinal cord injury.A cannabinoid type 2 receptor agonist attenuates blood-brain barrier damage and neurodegeneration in a murine model of traumatic brain injury.Phase 1 Randomized, Double-Blind, Placebo-Controlled Study to Determine the Safety, Tolerability, and Pharmacokinetics of a Single Escalating Dose and Repeated Doses of CN-105 in Healthy Adult Subjects.ApoE mimetic ameliorates motor deficit and tissue damage in rat spinal cord injury.
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P2860
COG1410 improves cognitive performance and reduces cortical neuronal loss in the traumatically injured brain
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on January 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
COG1410 improves cognitive per ...... he traumatically injured brain
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COG1410 improves cognitive per ...... e traumatically injured brain.
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type
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COG1410 improves cognitive per ...... he traumatically injured brain
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COG1410 improves cognitive per ...... e traumatically injured brain.
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COG1410 improves cognitive per ...... he traumatically injured brain
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COG1410 improves cognitive per ...... e traumatically injured brain.
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P2093
P2860
P356
P1476
COG1410 improves cognitive per ...... he traumatically injured brain
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P2093
Michael P Vitek
Michael R Hoane
Nicholas Kaufman
Suzanne E McKenna
P2860
P304
P356
10.1089/NEU.2008.0565
P577
2009-01-01T00:00:00Z