Protection of the heart by treatment with a divalent-copper-selective chelator reveals a novel mechanism underlying cardiomyopathy in diabetic rats.
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Contractile apparatus dysfunction early in the pathophysiology of diabetic cardiomyopathyDiabetic cardiomyopathy is associated with defective myocellular copper regulation and both defects are rectified by divalent copper chelationHigh or low calcium intake increases cardiovascular disease risks in older patients with type 2 diabetes.The afterload-dependent peak efficiency of the isolated working rat heart is unaffected by streptozotocin-induced diabetes.Streptozotocin-induced diabetes prolongs twitch duration without affecting the energetics of isolated ventricular trabeculae.Mechanisms underlying the impaired contractility of diabetic cardiomyopathy.Copper-induced reduction in myocardial fibrosis is associated with increased matrix metalloproteins in a rat model of cardiac hypertrophy.Deep sea minerals prolong life span of streptozotocin-induced diabetic rats by compensatory augmentation of the IGF-I-survival signaling and inhibition of apoptosis.Cellular apoptosis and cardiac dysfunction in STZ-induced diabetic rats attenuated by anthocyanins via activation of IGFI-R/PI3K/Akt survival signaling.Depotentiation of intact rat cardiac muscle unmasks an Epac-dependent increase in myofilament Ca(2+) sensitivity.Copper chelation by trientine dihydrochloride inhibits liver RFA-induced inflammatory responses in vivo.Oolong tea prevents cardiomyocyte loss against hypoxia by attenuating p-JNK mediated hypertrophy and enhancing P-IGF1R, p-akt, and p-Badser136 activity and by fortifying NRF2 antioxidation system.The Rho kinase inhibitor, fasudil, ameliorates diabetes-induced cardiac dysfunction by improving calcium clearance and actin remodeling.
P2860
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P2860
Protection of the heart by treatment with a divalent-copper-selective chelator reveals a novel mechanism underlying cardiomyopathy in diabetic rats.
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2013 nî lūn-bûn
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name
Protection of the heart by tre ...... rdiomyopathy in diabetic rats.
@en
Protection of the heart by tre ...... rdiomyopathy in diabetic rats.
@nl
type
label
Protection of the heart by tre ...... rdiomyopathy in diabetic rats.
@en
Protection of the heart by tre ...... rdiomyopathy in diabetic rats.
@nl
prefLabel
Protection of the heart by tre ...... rdiomyopathy in diabetic rats.
@en
Protection of the heart by tre ...... rdiomyopathy in diabetic rats.
@nl
P2093
P2860
P50
P356
P1476
Protection of the heart by tre ...... rdiomyopathy in diabetic rats.
@en
P2093
Anthony R J Phillips
Bernard Barry
Garth J S Cooper
Mark B Cannell
P2860
P2888
P356
10.1186/1475-2840-12-123
P407
P577
2013-08-28T00:00:00Z
P5875
P6179
1051820380