The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice.
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A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complexSIRT1 links CIITA deacetylation to MHC II activationUSP22 is a positive regulator of NFATc2 on promoting IL2 expressionMongersen, an oral Smad7 antisense oligonucleotide, in patients with active Crohn's diseaseSIRT1: A Novel Target for the Treatment of Muscular DystrophiesSIRT1 as a therapeutic target in inflammaging of the pulmonary diseaseImmune regulation by histone deacetylases: a focus on the alteration of FOXP3 activitySirtuins in hematological aging and malignancyStem cell treatment for Alzheimer's diseaseSirtuins in epigenetic regulationSirtuin deacylases: a molecular link between metabolism and immunitySIRT1 activators suppress inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB activityResveratrol Inhibits CD4+ T cell activation by enhancing the expression and activity of Sirt1Icariin induces synoviolin expression through NFE2L1 to protect neurons from ER stress-induced apoptosisA nutrient-sensitive interaction between Sirt1 and HNF-1α regulates Crp expressionAnalysis of sirtuin 1 expression reveals a molecular explanation of IL-2-mediated reversal of T-cell toleranceThe class III histone deacetylase sirtuin 1 in immune suppression and its therapeutic potential in rheumatoid arthritis.Expansion of oligodendrocyte progenitor cells following SIRT1 inactivation in the adult brain.Prevention and treatment of diabetes with resveratrol in a non-obese mouse model of type 1 diabetes.PPARγ negatively regulates T cell activation to prevent follicular helper T cells and germinal center formation.Rapid temporal control of Foxp3 protein degradation by sirtuin-1.Sirtuin 1 enzymatic activity is required for cartilage homeostasis in vivo in a mouse modelA novel microRNA-132-sirtuin-1 axis underlies aberrant B-cell cytokine regulation in patients with relapsing-remitting multiple sclerosis [corrected].Activation of Sirt1 by resveratrol inhibits TNF-α induced inflammation in fibroblastsNAD+-dependent sirtuin 1 and 6 proteins coordinate a switch from glucose to fatty acid oxidation during the acute inflammatory response.Renal protective effect of sirtuin 1Hrd1-mediated BLIMP-1 ubiquitination promotes dendritic cell MHCII expression for CD4 T cell priming during inflammation.DBC1 is a suppressor of B cell activation by negatively regulating alternative NF-κB transcriptional activity.Epigenetic enzymes are the therapeutic targets for CD4(+)CD25(+/high)Foxp3(+) regulatory T cellsResveratrol possesses protective effects in a pristane-induced lupus mouse model.Sirtuin-1 targeting promotes Foxp3+ T-regulatory cell function and prolongs allograft survival.The type III histone deacetylase Sirt1 protein suppresses p300-mediated histone H3 lysine 56 acetylation at Bclaf1 promoter to inhibit T cell activationSirtuin-1 regulation of mammalian metabolismAn exploratory double-blind, randomized clinical trial with selisistat, a SirT1 inhibitor, in patients with Huntington's disease.c-Abl-mediated tyrosine phosphorylation of the T-bet DNA-binding domain regulates CD4+ T-cell differentiation and allergic lung inflammationDendritic cell SIRT1-HIF1α axis programs the differentiation of CD4+ T cells through IL-12 and TGF-β1.Stem cell transplantation upregulates Sirt1 and antioxidant expression, ameliorating fatty liver in type 2 diabetic mice.Basic leucine zipper transcription factor, ATF-like (BATF) regulates epigenetically and energetically effector CD8 T-cell differentiation via Sirt1 expressionSirtuin 1 is a negative regulator of parathyroid hormone stimulation of matrix metalloproteinase 13 expression in osteoblastic cells: role of sirtuin 1 in the action of PTH on osteoblasts.SirT1: a guardian at the gates of adipose tissue inflammation.
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The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on October 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The type III histone deacetyla ...... of T cell tolerance in mice.
@en
The type III histone deacetyla ...... of T cell tolerance in mice.
@nl
type
label
The type III histone deacetyla ...... of T cell tolerance in mice.
@en
The type III histone deacetyla ...... of T cell tolerance in mice.
@nl
prefLabel
The type III histone deacetyla ...... of T cell tolerance in mice.
@en
The type III histone deacetyla ...... of T cell tolerance in mice.
@nl
P2093
P2860
P356
P1476
The type III histone deacetyla ...... of T cell tolerance in mice.
@en
P2093
Beixue Gao
Habib Zaghouani
Helen Braley-Mullen
Jinping Zhang
Michael W McBurney
Rohit Divekar
Sang-Myeong Lee
Stephen Shannon
P2860
P304
P356
10.1172/JCI38902
P407
P577
2009-10-01T00:00:00Z