Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease. - Wikidata - awgldk - TriplyDB

Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease.

Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease.

http://www.wikidata.org/entity/Q37364086

about

Nuclear factor erythroid 2-related factor 2 facilitates neuronal glutathione synthesis by upregulating neuronal excitatory amino acid transporter 3 expression.Mitochondrial Dysfunction Contributes to the Pathogenesis of Alzheimer's Disease The Nrf2-ARE pathway: a valuable therapeutic target for the treatment of neurodegenerative diseases The Janus face of the heme oxygenase/biliverdin reductase system in Alzheimer disease: it's time for reconciliation Targeting the prodromal stage of Alzheimer's disease: bioenergetic and mitochondrial opportunities Binding mode and structure-activity relationships around direct inhibitors of the Nrf2-Keap1 complex Dietary Phytochemicals in Neuroimmunoaging: A New Therapeutic Possibility for Humans?When NRF2 talks, who's listening?Omega-3 polyunsaturated fatty acids protect neural progenitor cells against oxidative injury The complexity of the Nrf2 pathway: beyond the antioxidant response Adaptive cellular stress pathways as therapeutic targets of dietary phytochemicals: focus on the nervous system Genetic mechanisms of coffee extract protection in a Caenorhabditis elegans model of β-amyloid peptide toxicity Therapeutic advantage of pro-electrophilic drugs to activate the Nrf2/ARE pathway in Alzheimer's disease models Lentiviral delivery of a vesicular glutamate transporter 1 (VGLUT1)-targeting short hairpin RNA vector into the mouse hippocampus impairs cognition Antroquinonol Lowers Brain Amyloid-β Levels and Improves Spatial Learning and Memory in a Transgenic Mouse Model of Alzheimer's Disease.Vanillic acid attenuates Aβ1-42-induced oxidative stress and cognitive impairment in mice.Oral administration of methysticin improves cognitive deficits in a mouse model of Alzheimer's disease.The relationship between iron dyshomeostasis and amyloidogenesis in Alzheimer's disease: Two sides of the same coin.Methylene blue upregulates Nrf2/ARE genes and prevents tau-related neurotoxicity NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology.NRF2, cancer and calorie restriction Role of the Keap1/Nrf2 pathway in neurodegenerative diseases.CD36 upregulation mediated by intranasal LV-NRF2 treatment mitigates hypoxia-induced progression of Alzheimer's-like pathogenesis.Fractalkine attenuates excito-neurotoxicity via microglial clearance of damaged neurons and antioxidant enzyme heme oxygenase-1 expression Neuroprotective strategies involving ROS in Alzheimer disease.Reactive oxygen species in the regulation of synaptic plasticity and memory.Mitochondria and antioxidant targeted therapeutic strategies for Alzheimer's disease.Production of monocytic cells from bone marrow stem cells: therapeutic usage in Alzheimer's disease.NRF2 promotes neuronal survival in neurodegeneration and acute nerve damage.A transgenic mouse model for monitoring oxidative stress.The biphasic role of microglia in Alzheimer's disease.A Cultivated Form of a Red Seaweed (Chondrus crispus), Suppresses β-Amyloid-Induced Paralysis in Caenorhabditis elegans Nrf2/ARE Signaling Pathway: Key Mediator in Oxidative Stress and Potential Therapeutic Target in ALS Morris Water Maze Training in Mice Elevates Hippocampal Levels of Transcription Factors Nuclear Factor (Erythroid-derived 2)-like 2 and Nuclear Factor Kappa B p65.Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease.DNA Demethylation Upregulated Nrf2 Expression in Alzheimer's Disease Cellular Model Calstabin 2: An important regulator for learning and memory in mice.Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes.The Ames dwarf mutation attenuates Alzheimer's disease phenotype of APP/PS1 mice.Nrf2--a therapeutic target for the treatment of neurodegenerative diseases.

P2860

Q24631707-11D271A2-D2E5-4D27-BE81-2733A8140BBA Q26801929-175390F5-984D-4116-9275-14049812367A Q26822972-58ECC547-AC9D-4839-B634-F195800B1892 Q26823454-20235140-54DB-477B-983C-D8FB0E8CF26F Q27338799-D06C1991-62CB-4667-823B-5A78CF1CA2B6 Q27689053-62B28AFA-14C3-4182-ABF0-C6EB8348E2C4 Q28075814-67CF6660-E88D-42D7-A065-DBDF72829D21 Q28384223-E20DA622-B4F6-4B9E-8210-C0D6DD5A9A4C Q28387639-77F4D626-CB42-428D-94D6-438A4AE3C6D0 Q28389296-38D09FB4-92C0-4CE2-8320-3632DED81184 Q28389419-B2407FDC-A255-49F3-89F9-D15101CDAAAA Q28748529-786A293F-017D-478E-9DA2-598F4ADE9C2D Q28818353-E0367650-85D6-4148-8E68-1E037FE13D96 Q30422055-871BFBD2-2B21-4513-B605-08EC0CAA613E Q30668645-6B24E4EB-DEEF-4811-ADA8-55E717AE691E Q30835280-21112277-3899-4D0D-81DA-4581E51736ED Q30847085-534961DA-A679-40B6-80E4-5967FFCF0F24 Q30989565-4426B148-53E4-4584-AEAE-D38E7F3CAC34 Q33784466-C3BB2782-9842-47BD-AECB-154A58E070CA Q33900736-897C5949-6A2E-4CFC-9404-7AA3E61144F4 Q34148599-646112AB-0435-4E7A-93F5-304DB811D210 Q34464138-2729A264-2682-4C72-8548-F701E9301316 Q34471077-6DB2ECAE-F0DF-4700-9125-EEEA7E7D8B7D Q34503290-A881892B-EC45-4CB3-95C2-DF5104A68378 Q34757939-83A00463-7396-454C-825C-A7BB56DCE63D Q34805998-4B8AF814-FC28-4D28-87BF-39C2C0821010 Q34994270-7085E6DE-046F-437D-AD4E-3E3D785F254B Q35195013-24AAC569-D9F9-4EEB-94AC-9F0D5C9B132F Q35408649-8C5A80A1-756B-427E-AA08-23A6E183C68C Q35681293-6D0932F4-9253-4ABC-B1DC-12D1E98F64D7 Q35978959-403D9E4B-6188-4D59-8F07-3A0286C22F89 Q36226777-2C7AD9AD-9FA6-4335-8103-CF73A86FBB9D Q36288479-FA449DD7-9901-492E-9792-81CDCFF531F5 Q36290099-DC766B03-1191-4CAF-8DC0-95201F31E35E Q36295178-D3084426-BEE0-4BAD-80F4-8A670462CCC5 Q36427465-20C1795E-F892-423C-963C-3D35C973D00A Q36592065-17DB3103-1ABF-4074-B5EC-261CB783988A Q36622182-81FE4654-7330-4424-B036-2272E7ADAD01 Q36686413-1AB01CCF-F030-44CD-B9E0-02E09EFB2383 Q36732766-8A991008-B5C4-4EAB-9248-6AE6F96AACA9

P2860

Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease.

http://www.wikidata.org/entity/Q37364086

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 10 September 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Intrahippocampal injection of ...... model of Alzheimer's disease.

@en

Intrahippocampal injection of ...... model of Alzheimer's disease.

@nl

type

label

Intrahippocampal injection of ...... model of Alzheimer's disease.

@en

Intrahippocampal injection of ...... model of Alzheimer's disease.

@nl

prefLabel

Intrahippocampal injection of ...... model of Alzheimer's disease.

@en

Intrahippocampal injection of ...... model of Alzheimer's disease.

@nl

P1433

Q37364086-CF0F75EC-81D4-470B-94D1-2D3BD271BF15

P1476

Q37364086-907239CB-2427-455B-A50C-DF70342706E8

P2093

Q37364086-011B597F-3480-48AE-8C4A-98B1C1FD7632

Q37364086-1245D014-6801-4048-8535-63C8863FA34E

Q37364086-35E30EAF-7455-48D9-9D29-D37F29D08318

Q37364086-3A3BC80D-6E39-4375-8C22-0870C56E36D5

Q37364086-5C36BB57-F8D1-41DF-A980-8CA8768BC985

Q37364086-BDF3B336-DCD1-47E1-B8A3-54F51BBF7856

Q37364086-C93FCE1F-7E3D-4BF2-89CD-4D9EC9F5F76A

Q37364086-DBF9C649-501C-45D8-97E2-1D12C8FFCD63

P2860

Q37364086-033C79B3-C94A-42C9-A778-6E5D56F1E39F

Q37364086-0B5DDC54-DC1B-4BE6-99E9-43674193678D

Q37364086-0D0FAF35-4DE7-4E03-A229-3C1B665D59FB

Q37364086-1827BA64-22CF-43D6-B6A4-FFAF2DB2ACBE

Q37364086-1DA6747A-7677-4775-99AB-02BC91986D3B

Q37364086-220734DB-EA27-4FAD-8434-40A8F688FDD5

Q37364086-3710D727-D2C3-465A-8326-96C64388E039

Q37364086-3E08A413-0658-4D27-99CE-FC8FBD0F28B6

Q37364086-41C2F6FD-55DA-4215-896A-5981D46929FD

Q37364086-5A048FA8-A226-470E-8737-60D98E9A84B5

P304

Q37364086-830D4E0F-9109-4790-A697-17ED02849EE8

P31

Q37364086-D8424520-50AE-4F04-807B-4C54C694ECA1

P356

Q37364086-3AC94ADD-758A-45B1-B341-058922317F1C

P407

Q37364086-E4DE3097-0094-4977-9953-932E637AC00E

P433

Q37364086-8DEAB5CF-14DF-47D8-BDBA-408AB0AE7169

P478

Q37364086-CA6FDA56-E26A-4171-B05F-B0402E267933

P50

Q37364086-30A675D1-C542-44CB-B044-36A6B10259BF

Q37364086-5C917E89-966A-4954-824F-11E2EA9A3D6F

Q37364086-A40F6CF4-5BAB-4325-AC7F-90526EF01D68

P577

Q37364086-29B31115-E24F-4B33-A0C3-4FAB1C809737

P5875

Q37364086-5BD6B7C6-7CF5-43FE-869B-CF4570A5D3DB

P698

Q37364086-A430F2FF-DC10-4FAB-BBBC-8EC467ED2A9A

P921

Q37364086-0A83AFD5-72AC-4C8F-8928-BD67B7604636

Q37364086-B587C24D-CC61-45D6-8B60-E12D499E30E7

P932

Q37364086-F4E2B169-5F56-4538-B4EB-FBCF75DBA13A

P356

PNAS.0908397106

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Intrahippocampal injection of ...... model of Alzheimer's disease.

@en

P2093

Hanna Leinonen

http://www.w3.org/2001/XMLSchema#string

Heikki Tanila

http://www.w3.org/2001/XMLSchema#string

Jari Koistinaho

http://www.w3.org/2001/XMLSchema#string

Katja Kanninen

http://www.w3.org/2001/XMLSchema#string

Milla Koistinaho

http://www.w3.org/2001/XMLSchema#string

Riikka Heikkinen

http://www.w3.org/2001/XMLSchema#string

Taisia Rolova

http://www.w3.org/2001/XMLSchema#string

Tarja Malm

http://www.w3.org/2001/XMLSchema#string

P2860

Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

No advantage of A beta 42-lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studies

The Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegeneration

NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo

Alzheimer's disease: genes, proteins, and therapy

Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

Alzheimer's disease: the amyloid cascade hypothesis

Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression

P304

16505-16510

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.0908397106

http://www.w3.org/2001/XMLSchema#string

P407

P433

38

http://www.w3.org/2001/XMLSchema#string

P478

106

http://www.w3.org/2001/XMLSchema#string

P50

Seppo Ylä-Herttuala

Anna-Liisa Levonen

Susanna Kuhmonen

P577

2009-09-10T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

26871504

http://www.w3.org/2001/XMLSchema#string

P698

19805328

http://www.w3.org/2001/XMLSchema#string

P921

Alzheimer's disease

vector-borne disease

P932

2752553

http://www.w3.org/2001/XMLSchema#string