aPKClambda/iota promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6. - Wikidata - awgldk - TriplyDB

aPKClambda/iota promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6.

aPKClambda/iota promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6.

http://www.wikidata.org/entity/Q37364129

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Systematic review of peri-operative prognostic biomarkers in pancreatic ductal adenocarcinoma Adenosine-binding motif mimicry and cellular effects of a thieno[2,3-d]pyrimidine-based chemical inhibitor of atypical protein kinase C isoenzymes Asymmetric cell division of stem and progenitor cells during homeostasis and cancer Genetic variability of the mTOR pathway and prostate cancer risk in the European Prospective Investigation on Cancer (EPIC).Stat3: linking inflammation to epithelial cancer - more than a "gut" feeling?PKCλ/ι signaling promotes triple-negative breast cancer growth and metastasis Growth hormone abolishes beneficial effects of calorie restriction in long-lived Ames dwarf mice.Protein kinase Cι expression and oncogenic signaling mechanisms in cancer.Minireview: Alternative activation pathways for the androgen receptor in prostate cancer.IL-6 promotes prostate tumorigenesis and progression through autocrine cross-activation of IGF-IR.Loss of the polarity protein PAR3 activates STAT3 signaling via an atypical protein kinase C (aPKC)/NF-κB/interleukin-6 (IL-6) axis in mouse mammary cells.JunD-mediated repression of GADD45α and γ regulates escape from cell death in prostate cancer Protein kinase C iota as a therapeutic target in alveolar rhabdomyosarcoma.Activation of nuclear factor κB (NF-κB) in prostate cancer is mediated by protein kinase C epsilon (PKCepsilon)New therapy targeting differential androgen receptor signaling in prostate cancer stem/progenitor vs. non-stem/progenitor cells.c-Myc phosphorylation by PKCζ represses prostate tumorigenesis.Antitumor activity of IL-32β through the activation of lymphocytes, and the inactivation of NF-κB and STAT3 signals Regulation of polarized morphogenesis by protein kinase C iota in oncogenic epithelial spheroids.Interleukin-6: a multifunctional targetable cytokine in human prostate cancer.Mechanisms of persistent activation of the androgen receptor in CRPC: recent advances and future perspectives.Role of signaling transduction pathways in development of castration-resistant prostate cancer.Advanced prostate cancer: reinforcing the strings between inflammation and the metastatic behavior.Stat3: linking inflammation to (gastrointestinal) tumourigenesis.Protein kinase C and cancer: what we know and what we do not.Phosphoproteome analysis demonstrates the potential role of THRAP3 phosphorylation in androgen-independent prostate cancer cell growth.Adipocyte-derived monocyte chemotactic protein-1 (MCP-1) promotes prostate cancer progression through the induction of MMP-2 activity.Epidermal growth factor receptor tyrosine kinase inhibition up-regulates interleukin-6 in cancer cells and induces subsequent development of interstitial pneumonia.Identification of miR-30d as a novel prognostic maker of prostate cancer.Lack of an association between the aPKCλ/ι expression in prostate cancer and the patient outcomes.Prostate-specific IL-6 transgene autonomously induce prostate neoplasm through amplifying inflammation in the prostate and peri-prostatic adipose tissue.High expression of KIBRA in low atypical protein kinase C-expressing gastric cancer correlates with lymphatic invasion and poor prognosis.PRKCI promotes immune suppression in ovarian cancer.Intratumoural evolutionary landscape of high-risk prostate cancer: the PROGENY study of genomic and immune parameters.miR-217-5p induces apoptosis by directly targeting PRKCI, BAG3, ITGAV and MAPK1 in colorectal cancer cells.Targeting atypical protein kinase C iota reduces viability in glioblastoma stem-like cells via a notch signaling mechanism.Beyond androgen deprivation: ancillary integrative strategies for targeting the androgen receptor addiction of prostate cancer.Coexpression of aPKCλ/ι and IL-6 in prostate cancer tissue correlates with biochemical recurrence.Inflammation and NF-κB Signaling in Prostate Cancer: Mechanisms and Clinical Implications

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aPKClambda/iota promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6.

http://www.wikidata.org/entity/Q37364129

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 02 September 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

aPKClambda/iota promotes growt ...... l activation of interleukin-6.

@en

aPKClambda/iota promotes growt ...... l activation of interleukin-6.

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type

label

aPKClambda/iota promotes growt ...... l activation of interleukin-6.

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aPKClambda/iota promotes growt ...... l activation of interleukin-6.

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prefLabel

aPKClambda/iota promotes growt ...... l activation of interleukin-6.

@en

aPKClambda/iota promotes growt ...... l activation of interleukin-6.

@nl

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PNAS.0907044106

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Proceedings of the National Academy of Sciences of the United States of America

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aPKClambda/iota promotes growt ...... l activation of interleukin-6.

@en

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Hiroji Uemura

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Hitoshi Ishiguro

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Kazunori Akimoto

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Noboru Nakaigawa

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Takeshi Sasaki

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Yasuyuki Kojima

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Yoji Nagashima

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Yoshinobu Kubota

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Yukari Ishiguro-Imagawa

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P2860

The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation.

aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity

Principles of interleukin (IL)-6-type cytokine signalling and its regulation

Activation of IkappaB kinase beta by protein kinase C isoforms

Protein kinase C lambda/iota (PKClambda/iota): a PKC isotype essential for the development of multicellular organisms

Protein kinase C and lipid signaling for sustained cellular responses

Cancer statistics, 2007

Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer.

Interleukin-6 regulates androgen receptor activity and prostate cancer cell growth.

Par-4 inducible apoptosis in prostate cancer cells.

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scholarly article

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10.1073/PNAS.0907044106

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19805306

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