Inducible expression of active protein phosphatase-1 inhibitor-1 enhances basal cardiac function and protects against ischemia/reperfusion injury. - Wikidata - awgldk - TriplyDB

Inducible expression of active protein phosphatase-1 inhibitor-1 enhances basal cardiac function and protects against ischemia/reperfusion injury.

Inducible expression of active protein phosphatase-1 inhibitor-1 enhances basal cardiac function and protects against ischemia/reperfusion injury.

http://www.wikidata.org/entity/Q37364808

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Modulation of cardiac contractility by the phospholamban/SERCA2a regulatome Cardiac I-1c overexpression with reengineered AAV improves cardiac function in swine ischemic heart failure Heart failure-inducible gene therapy targeting protein phosphatase 1 prevents progressive left ventricular remodeling Potential of protein phosphatase inhibitor 1 as biomarker of pancreatic β-cell injury in vitro and in vivo Clusters of conserved beta cell marker genes for assessment of beta cell phenotype.Changes in fibroblast mechanostat set point and mechanosensitivity: an adaptive response to mechanical stress in floppy eyelid syndrome CaMKII-dependent phosphorylation of cardiac ryanodine receptors regulates cell death in cardiac ischemia/reperfusion injury.Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy.Fasudil protects the heart against ischemia-reperfusion injury by attenuating endoplasmic reticulum stress and modulating SERCA activity: the differential role for PI3K/Akt and JAK2/STAT3 signaling pathways.The large isoforms of A-kinase anchoring protein 18 mediate the phosphorylation of inhibitor-1 by protein kinase A and the inhibition of protein phosphatase 1 activity.Rescuing the failing heart by targeted gene transfer Phospholamban interactome in cardiac contractility and survival: A new vision of an old friend.Active inhibitor-1 maintains protein hyper-phosphorylation in aging hearts and halts remodeling in failing hearts.The extended PP1 toolkit: designed to create specificity.Altered myocardial calcium cycling and energetics in heart failure--a rational approach for disease treatment.Chasing cardiac physiology and pathology down the CaMKII cascade Ablation of junctin or triadin is associated with increased cardiac injury following ischaemia/reperfusion Human G109E-inhibitor-1 impairs cardiac function and promotes arrhythmias.Alterations in the interactome of serine/threonine protein phosphatase type-1 in atrial fibrillation patients.Potential of gene therapy as a treatment for heart failure Novel role of HAX-1 in ischemic injury protection involvement of heat shock protein 90 Constitutive phosphorylation of inhibitor-1 at Ser67 and Thr75 depresses calcium cycling in cardiomyocytes and leads to remodeling upon aging.Phosphorylation state-dependent interaction between AKAP7δ/γ and phospholamban increases phospholamban phosphorylation.AAV9.I-1c delivered via direct coronary infusion in a porcine model of heart failure improves contractility and mitigates adverse remodeling Altered sarcoplasmic reticulum calcium cycling--targets for heart failure therapy.Novel Ser/Thr protein phosphatases in cell death regulation Role of protein phosphatase-1 inhibitor-1 in cardiac physiology and pathophysiology.The role of CaMKII regulation of phospholamban activity in heart disease.Tissue proteomics in atherosclerosis: elucidating the molecular mechanisms of cardiovascular diseases.Sarcoplasmic reticulum Ca(2+) ATPase as a therapeutic target for heart failure.AKAP phosphatase complexes in the heart.Targeted gene therapy for the treatment of heart failure.Calcium cycling proteins and their association with heart failure.Cardiac gene therapy: from concept to reality.Gene therapy for heart failure: where do we stand?SERCA2a: a prime target for modulation of cardiac contractility during heart failure.Heart failure-specific changes in protein kinase signalling.I-1-deficiency negatively impacts survival in a cardiomyopathy mouse model.Regulating the regulator: Insights into the cardiac protein phosphatase 1 interactome.Promise of adeno-associated virus as a gene therapy vector for cardiovascular diseases.

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Inducible expression of active protein phosphatase-1 inhibitor-1 enhances basal cardiac function and protects against ischemia/reperfusion injury.

http://www.wikidata.org/entity/Q37364808

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bilimsel makale

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scientific article published on 19 March 2009

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vedecký článok

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Inducible expression of active ...... t ischemia/reperfusion injury.

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Inducible expression of active ...... t ischemia/reperfusion injury.

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Inducible expression of active ...... t ischemia/reperfusion injury.

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Inducible expression of active ...... t ischemia/reperfusion injury.

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Inducible expression of active ...... t ischemia/reperfusion injury.

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CIRCRESAHA.108.189811

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Circulation Research

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Inducible expression of active ...... st ischemia/reperfusion injury

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Anand Pathak

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Bryan Mitton

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Evangelia G Kranias

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Jeffrey Robbins

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Jiang Qian

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Keith Jones

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Patricia Rodriguez

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Persoulla Nicolaou

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Roger J Hajjar

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Xiaoping Ren

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P2860

Heart Disease and Stroke Statistics--2008 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee

Endoplasmic reticulum stress: cell life and death decisions.

Protein phosphatase 1--targeted in many directions

Evidence for protein phosphatase inhibitor-1 playing an amplifier role in beta-adrenergic signaling in cardiac myocytes

Prolonged endoplasmic reticulum stress in hypertrophic and failing heart after aortic constriction: possible contribution of endoplasmic reticulum stress to cardiac myocyte apoptosis

Physiologic importance of protein phosphatase inhibitors

Phospholamban gene dosage effects in the mammalian heart

ER stress contributes to ischemia-induced cardiomyocyte apoptosis

PKC-alpha regulates cardiac contractility and propensity toward heart failure

Dilated cardiomyopathy caused by aberrant endoplasmic reticulum quality control in mutant KDEL receptor transgenic mice.

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1012-1020

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scholarly article

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10.1161/CIRCRESAHA.108.189811

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8

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104

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Sakthivel Sadayappan

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2009-03-19T00:00:00Z

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24213514

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19299645

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reperfusion injury

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2752882

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