An iron-carboxylate bond links the heme units of malaria pigment
about
The therapeutic potential of metal-based antimalarial agents: implications for the mechanism of actionImproved methods for magnetic purification of malaria parasites and haemozoinInterference with hemozoin formation represents an important mechanism of schistosomicidal action of antimalarial quinoline methanolsArtemisinin, an Endoperoxide Antimalarial, Disrupts the Hemoglobin Catabolism and Heme Detoxification Systems in Malarial ParasiteOn the molecular mechanism of chloroquine's antimalarial actionHemozoin: oil versus waterA magneto-optic route toward the in vivo diagnosis of malaria: preliminary results and preclinical trial dataDirect tests of enzymatic heme degradation by the malaria parasite Plasmodium falciparumOn the mechanism of chloroquine resistance in Plasmodium falciparumZinc finger-like motifs in rat ribosomal proteins S27 and S29Investigation of the Plasmodium falciparum food vacuole through inducible expression of the chloroquine resistance transporter (PfCRT)A novel way to grow hemozoin-like crystals in vitro and its use to screen for hemozoin inhibiting antimalarial compoundsMalarial hemozoin: from target to toolThe neutral lipid composition present in the digestive vacuole of Plasmodium falciparum concentrates heme and mediates β-hematin formation with an unusually low activation energy.Malaria pigment crystals as magnetic micro-rotors: key for high-sensitivity diagnosis.Hematin polymerization assay as a high-throughput screen for identification of new antimalarial pharmacophores.Identification and characterization of heme-interacting proteins in the malaria parasite, Plasmodium falciparum.Resonance Raman spectroscopy in malaria research.Synthetic Plasmodium-like hemozoin activates the immune response: a morphology - function studyIncrease on the initial soluble heme levels in acidic conditions is an important mechanism for spontaneous heme crystallization in vitroPhagocytosis of the malarial pigment, hemozoin, impairs expression of major histocompatibility complex class II antigen, CD54, and CD11c in human monocytesTwo complex genotypes relevant to the kynurenine pathway and melanotropin function show association with schizophrenia and bipolar disorderSingle-molecule analysis reveals that DNA replication dynamics vary across the course of schizogony in the malaria parasite Plasmodium falciparum.Lipophilic mediated assays for beta-hematin inhibitors.Macrophage migration inhibitory factor release by macrophages after ingestion of Plasmodium chabaudi-infected erythrocytes: possible role in the pathogenesis of malarial anemiaEllagitannins of the fruit rind of pomegranate (Punica granatum) antagonize in vitro the host inflammatory response mechanisms involved in the onset of malariaPurified malaria pigment (hemozoin) enhances dendritic cell maturation and modulates the isotype of antibodies induced by a DNA vaccineLigands of the peripheral benzodiazepine receptor are potent inhibitors of Plasmodium falciparum and Toxoplasma gondii in vitroTaste for blood: hemoglobin as a nutrient source for pathogens.Severe malarial anemia: innate immunity and pathogenesis.In vitro and in vivo antimalarial activity of amphiphilic naphthothiazolium salts with amine-bearing side chains.Schistosomiasis chemotherapy.Heme and blood-feeding parasites: friends or foes?Comparative analysis of gene expression changes mediated by individual constituents of hemozoin.Probing the chloroquine resistance locus of Plasmodium falciparum with a novel class of multidentate metal(III) coordination complexes.Structural and morphological characterization of hemozoin produced by Schistosoma mansoni and Rhodnius prolixus.Dendrimeric template of Plasmodium falciparum histidine rich protein II repeat motifs bearing Asp→Asn mutation exhibits heme binding and β-hematin formation.Zinc protoporphyrin IX binds heme crystals to inhibit the process of crystallization in Plasmodium falciparumReduced peripheral PGE2 biosynthesis in Plasmodium falciparum malaria occurs through hemozoin-induced suppression of blood mononuclear cell cyclooxygenase-2 gene expression via an interleukin-10-independent mechanism.Chloroquine resistance in the malarial parasite, Plasmodium falciparum.
P2860
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P2860
An iron-carboxylate bond links the heme units of malaria pigment
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 1991
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
An iron-carboxylate bond links the heme units of malaria pigment
@en
An iron-carboxylate bond links the heme units of malaria pigment.
@nl
type
label
An iron-carboxylate bond links the heme units of malaria pigment
@en
An iron-carboxylate bond links the heme units of malaria pigment.
@nl
prefLabel
An iron-carboxylate bond links the heme units of malaria pigment
@en
An iron-carboxylate bond links the heme units of malaria pigment.
@nl
P2093
P2860
P356
P1476
An iron-carboxylate bond links the heme units of malaria pigment
@en
P2093
Flitter WD
Goldberg DE
Henderson GB
Swiggard WJ
P2860
P304
P356
10.1073/PNAS.88.2.325
P407
P577
1991-01-01T00:00:00Z