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Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule ProbesML336: Development of Quinazolinone-Based Inhibitors Against Venezuelan Equine Encephalitis Virus (VEEV)Evaluation of anti-Zika virus activities of broad-spectrum antivirals and NIH clinical collection compounds using a cell-based, high-throughput screen assayDiscovery of a novel compound with anti-venezuelan equine encephalitis virus activity that targets the nonstructural protein 2A Pan-GTPase Inhibitor as a Molecular ProbeIdentification and Characterization of Influenza Virus Entry Inhibitors through Dual Myxovirus High-Throughput ScreeningAntiparasitic lethality of sulfonamidebenzamides in kinetoplastids.Identification of Novel Plasmodium falciparum Hexokinase Inhibitors with Antiparasitic Activity.Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold.Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells.Discovery of a Potent, S1P3-Sparing Benzothiazole Agonist of Sphingosine-1-Phosphate Receptor 1 (S1P1)Discovery of AMG 369, a Thiazolo[5,4-b]pyridine Agonist of S1P1 and S1P5.High-throughput screening identifies a bisphenol inhibitor of SV40 large T antigen ATPase activityA competitive nucleotide binding inhibitor: in vitro characterization of Rab7 GTPase inhibitionA selective ATP-binding cassette subfamily G member 2 efflux inhibitor revealed via high-throughput flow cytometry.Development of (E)-2-((1,4-dimethylpiperazin-2-ylidene)amino)-5-nitro-N-phenylbenzamide, ML336: Novel 2-amidinophenylbenzamides as potent inhibitors of venezuelan equine encephalitis virusA cell based high-throughput screening approach for the discovery of new inhibitors of respiratory syncytial virusDiscovery of Sulfonamidebenzamides as Selective Apoptotic CHOP Pathway Activators of the Unfolded Protein Response.Interrogating a hexokinase-selected small-molecule library for inhibitors of Plasmodium falciparum hexokinase.Optimization of potent and selective quinazolinediones: inhibitors of respiratory syncytial virus that block RNA-dependent RNA-polymerase complex activity.Identification of a small molecule yeast TORC1 inhibitor with a multiplex screen based on flow cytometry(S)-N-(2,5-Dimethylphenyl)-1-(quinoline-8-ylsulfonyl)pyrrolidine-2-carboxamide as a small molecule inhibitor probe for the study of respiratory syncytial virus infection.Characterization of a Cdc42 protein inhibitor and its use as a molecular probe.One-pot, regiospecific assembly of (E)-benzamidines from δ- and γ-amino acids via an intramolecular aminoquinazolinone rearrangement.Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C.Syntheses of the Stemona alkaloids (+/-)-stenine, (+/-)-neostenine, and (+/-)-13-epineostenine using a stereodivergent Diels-Alder/azido-Schmidt reaction.Novel 5- and 6-subtituted benzothiazoles with improved physicochemical properties: potent S1P₁ agonists with in vivo lymphocyte-depleting activity.Discovery of a Broad-Spectrum Antiviral Compound That Inhibits Pyrimidine Biosynthesis and Establishes a Type 1 Interferon-Independent Antiviral State.Evaluation of substituted ebselen derivatives as potential trypanocidal agents.Optimization and Evaluation of Antiparasitic Benzamidobenzoic Acids as Inhibitors of Kinetoplastid Hexokinase 1.Characterization of a Cdc42 protein inhibitor and its use as a molecular probe.A targeted delivery strategy for the development of potent trypanocides.Palladium-Catalyzed Cyclocarbonylation of Pyridinylated Vinylogous Amides and Ureas to Generate Ring-Fused PyridopyrimidinonesA Novel Compound, ML336, Inhibits VEEV Replication by Interfering with Viral RNA SynthesisAn Ultra-High-Throughput Screen for Catalytic Inhibitors of Serine/Threonine Protein Phosphatases Types 1 and 5 (PP1C and PP5C)Function through bio-inspired, synthesis-informed design: step-economical syntheses of designed kinase inhibitors†Dedicated to Max Malacria, a friend and scholar whose science and creative contributions to step-economical synthesis have inspired usModulating N- versus O-arylation in pyrazolone-aryl halide couplingsStructure-guided design of substituted aza-benzimidazoles as potent hypoxia inducible factor-1α prolyl hydroxylase-2 inhibitorsPotent hFPRL1 (ALXR) agonists as potential anti-inflammatory agentsFacile C−N Cleavage in a Series of Bridged Lactams
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Jennifer E. Golden
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Jennifer E. Golden
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Jennifer E. Golden
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Jennifer E. Golden
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Jennifer E. Golden
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Jennifer E. Golden
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Jennifer E. Golden
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Jennifer E. Golden
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Jennifer E. Golden
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Jennifer E. Golden
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Jennifer E. Golden
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Jennifer E. Golden
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Jennifer E. Golden
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Jennifer E. Golden
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Jennifer E. Golden
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