Top3β is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation.
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The FMRP regulon: from targets to disease convergenceProteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2{middle dot}DNA and Top2{middle dot}RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2)Readers of histone methylarginine marks.Topoisomerase 3β is the major topoisomerase for mRNAs and linked to neurodevelopment and mental dysfunction.Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromesTyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).Tudor Domain Containing Protein 3 Promotes Tumorigenesis and Invasive Capacity of Breast Cancer CellsAn evolving view of epigenetic complexity in the brain.Topoisomerase 1 inhibition reversibly impairs synaptic function.Targeting bacterial topoisomerase I to meet the challenge of finding new antibiotics.Inhibition of Zn(II) binding type IA topoisomerases by organomercury compounds and Hg(II)Structural basis for suppression of hypernegative DNA supercoiling by E. coli topoisomerase IMaternal Modifiers and Parent-of-Origin Bias of the Autism-Associated 16p11.2 CNV.FANCM interacts with PCNA to promote replication traverse of DNA interstrand crosslinks.RNA topoisomerase is prevalent in all domains of life and associates with polyribosomes in animals.DNA and RNA topoisomerase activities of Top3β are promoted by mediator protein Tudor domain-containing protein 3Arginine methylation of USP9X promotes its interaction with TDRD3 and its anti-apoptotic activities in breast cancer cells.Deletion of TOP3β, a component of FMRP-containing mRNPs, contributes to neurodevelopmental disorders.Chromatin regulators, phenotypic robustness, and autism risk.Subcellular mRNA localisation at a glanceThe diverse roles and multiple forms of focal adhesion kinase in brain.Structural basis of the interaction between Topoisomerase IIIβ and the TDRD3 auxiliary factorTopoisomerase-mediated chromosomal break repair: an emerging player in many games.Arginine methylation facilitates the recruitment of TOP3B to chromatin to prevent R loop accumulation.Topoisomerases and the regulation of neural function.The elusive quest for RNA knots.Distinct expression patterns for type II topoisomerases IIA and IIB in the early foetal human telencephalon.Synthesizing topological structures containing RNA.Role of Protein Linked DNA Breaks in Cancer.Type IA DNA Topoisomerases: A Universal Core and Multiple Activities.An Assay for Detecting RNA Topoisomerase Activity.TopA, the Sulfolobus solfataricus topoisomerase III, is a decatenase.Type IA topoisomerases can be "magicians" for both DNA and RNA in all domains of life.Enhancer of zeste homolog 2-catalysed H3K27 trimethylation plays a key role in acute-on-chronic liver failure via TNF-mediated pathway.Arginine methylation of the C-terminus RGG motif promotes TOP3B topoisomerase activity and stress granule localization.The topoisomerase 3α zinc-finger domain T1 of Arabidopsis thaliana is required for targeting the enzyme activity to Holliday junction-like DNA repair intermediatesCARM1 methylates MED12 to regulate its RNA-binding ability
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Top3β is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 04 August 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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Top3β is an RNA topoisomerase ...... to promote synapse formation.
@en
Top3β is an RNA topoisomerase ...... to promote synapse formation.
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type
label
Top3β is an RNA topoisomerase ...... to promote synapse formation.
@en
Top3β is an RNA topoisomerase ...... to promote synapse formation.
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prefLabel
Top3β is an RNA topoisomerase ...... to promote synapse formation.
@en
Top3β is an RNA topoisomerase ...... to promote synapse formation.
@nl
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Top3β is an RNA topoisomerase ...... to promote synapse formation.
@en
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Albert C Shaw
Alexei Sharov
James Machamer
Jennifer L Martindale
Jiandong Yang
Minoru S H Ko
P2860
P2888
P304
P356
10.1038/NN.3479
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P577
2013-08-04T00:00:00Z
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P6179
1037235478