Conversion of 6-substituted tetrahydropterins to 7-isomers via phenylalanine hydroxylase-generated intermediates.
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Tetrahydrobiopterin biosynthesis, regeneration and functionsHyperphenylalaninemia with high levels of 7-biopterin is associated with mutations in the PCBD gene encoding the bifunctional protein pterin-4a-carbinolamine dehydratase and transcriptional coactivator (DCoH).Studies on the enzymatic and transcriptional activity of the dimerization cofactor for hepatocyte nuclear factor 1Mutation in the 4a-carbinolamine dehydratase gene leads to mild hyperphenylalaninemia with defective cofactor metabolismThree-dimensional structure of the bifunctional protein PCD/DCoH, a cytoplasmic enzyme interacting with transcription factor HNF1Characterization of the wild-type form of 4a-carbinolamine dehydratase and two naturally occurring mutants associated with hyperphenylalaninemiaCharacterization of a novel pterin intermediate formed in the catalytic cycle of tyrosine hydroxylaseIdentity of 4a-carbinolamine dehydratase, a component of the phenylalanine hydroxylation system, and DCoH, a transregulator of homeodomain proteinsOverexpression of pterin-4a-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 in human colon cancer.Identification of hepatic nuclear factor 1 binding sites in the 5' flanking region of the human phenylalanine hydroxylase gene: implication of a dual function of phenylalanine hydroxylase stimulator in the phenylalanine hydroxylation system."7-tetrahydrobiopterin," a naturally occurring analogue of tetrahydrobiopterin, is a cofactor for and a potential inhibitor of the aromatic amino acid hydroxylasesEnhanced synthesis of 5-hydroxy-l-tryptophan through tetrahydropterin regeneration.Tetrahydro-6-biopterin is associated with tetrahydro-7-biopterin in primary murine mast cells.High-resolution structures of the bifunctional enzyme and transcriptional coactivator DCoH and its complex with a product analogueHPLC analysis of tetrahydrobiopterin and its pteridine derivatives using sequential electrochemical and fluorimetric detection: application to tetrahydrobiopterin autoxidation and chemical oxidation.Distribution of 4a-hydroxytetrahydropterin dehydratase in rat tissues. Comparison with the aromatic amino acid hydroxylases.Biosynthesis of pteridines in Neurospora crassa, Phycomyces blakesleeanus and Euglena gracilis: detection and characterization of biosynthetic enzymes.Divergence in regulation of nitric-oxide synthase and its cofactor tetrahydrobiopterin by tumor necrosis factor-alpha. Ceramide potentiates nitric oxide synthesis without affecting GTP cyclohydrolase I activity.
P2860
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P2860
Conversion of 6-substituted tetrahydropterins to 7-isomers via phenylalanine hydroxylase-generated intermediates.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 1991
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Conversion of 6-substituted te ...... ylase-generated intermediates.
@en
Conversion of 6-substituted te ...... ylase-generated intermediates.
@nl
type
label
Conversion of 6-substituted te ...... ylase-generated intermediates.
@en
Conversion of 6-substituted te ...... ylase-generated intermediates.
@nl
prefLabel
Conversion of 6-substituted te ...... ylase-generated intermediates.
@en
Conversion of 6-substituted te ...... ylase-generated intermediates.
@nl
P2093
P2860
P356
P1476
Conversion of 6-substituted te ...... ylase-generated intermediates.
@en
P2093
P2860
P304
P356
10.1073/PNAS.88.2.385
P407
P577
1991-01-01T00:00:00Z