In Silico Improvement of beta3-peptide inhibitors of p53 x hDM2 and p53 x hDMX
about
Elucidation of Ligand-Dependent Modulation of Disorder-Order Transitions in the Oncoprotein MDM2Structure of a complex formed by a protein and a helical aromatic oligoamide foldamer at 2.1 Å resolutionA foldamer-dendrimer conjugate neutralizes synaptotoxic β-amyloid oligomersA spiroligomer α-helix mimic that binds HDM2, penetrates human cells and stabilizes HDM2 in cell culturePrediction of the water content in protein binding sitesN-acylpolyamine inhibitors of HDM2 and HDMX binding to p53.A β-peptide agonist of the GLP-1 receptor, a class B GPCR.Novel pyrrolopyrimidine-based α-helix mimetics: cell-permeable inhibitors of protein−protein interactionsMarkov models of the apo-MDM2 lid region reveal diffuse yet two-state binding dynamics and receptor poses for computational docking.Energetics of displacing water molecules from protein binding sites: consequences for ligand optimizationStabilized helical peptides: overview of the technologies and therapeutic promises.Peptide and peptoid foldamers in medicinal chemistry.De novo design: balancing novelty and confined chemical space.Targeting p53-MDM2-MDMX loop for cancer therapy.Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes.An overview of peptide and peptoid foldamers in medicinal chemistry.Microsecond simulations of mdm2 and its complex with p53 yield insight into force field accuracy and conformational dynamics.A stapled p53 helix overcomes HDMX-mediated suppression of p53.Positive allostery in metal ion binding by a cooperatively folded β-peptide bundle.Rotamer Libraries for the High-Resolution Design of β-Amino Acid Foldamers.
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P2860
In Silico Improvement of beta3-peptide inhibitors of p53 x hDM2 and p53 x hDMX
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on May 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
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name
In Silico Improvement of beta3-peptide inhibitors of p53 x hDM2 and p53 x hDMX
@en
In Silico Improvement of beta3-peptide inhibitors of p53 x hDM2 and p53 x hDMX.
@nl
type
label
In Silico Improvement of beta3-peptide inhibitors of p53 x hDM2 and p53 x hDMX
@en
In Silico Improvement of beta3-peptide inhibitors of p53 x hDM2 and p53 x hDMX.
@nl
prefLabel
In Silico Improvement of beta3-peptide inhibitors of p53 x hDM2 and p53 x hDMX
@en
In Silico Improvement of beta3-peptide inhibitors of p53 x hDM2 and p53 x hDMX.
@nl
P2093
P2860
P356
P1476
In Silico Improvement of beta3-peptide inhibitors of p53 x hDM2 and p53 x hDMX
@en
P2093
Alanna Schepartz
Elizabeth A Harker
Julian Tirado-Rives
Julien Michel
P2860
P304
P356
10.1021/JA901478E
P407
P577
2009-05-01T00:00:00Z