about
Mechanisms of immunosenescenceCancer classification using the Immunoscore: a worldwide task forceImmunosenescence and cancerRelationships between cancer and aging: a multilevel approachAgeing, autoimmunity and arthritis: Perturbations of TCR signal transduction pathways with ageing - a biochemical paradigm for the ageing immune systemImmunosenescence and vaccination.Age and immunityVaccination in the elderlyThe unmet need in the elderly: how immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccinesAge-associated accumulation of CMV-specific CD8+ T cells expressing the inhibitory killer cell lectin-like receptor G1 (KLRG1)HAGE, a cancer/testis antigen with potential for melanoma immunotherapy: identification of several MHC class I/II HAGE-derived immunogenic peptidesRecommendations from the iSBTc-SITC/FDA/NCI Workshop on Immunotherapy Biomarkers.Association of IFN-gamma signal transduction defects with impaired HLA class I antigen processing in melanoma cell lines.Distinct molecular mechanisms leading to deficient expression of ER-resident aminopeptidases in melanoma.Epigenetic and immune function profiles associated with posttraumatic stress disorder.Development of an MHC-class I peptide selection assay combining nanoparticle technology and matrix-assisted laser desorption/ionisation mass spectrometry.The concept of telomeric non-reciprocal recombination (TENOR) applied to human fibroblasts grown in serial cultures: concordance with genealogical data.SELDI-TOF-MS ProteinChip array profiling of T-cell clones propagated in long-term culture identifies human profilin-1 as a potential bio-marker of immunosenescenceSeropositivity to cytomegalovirus, inflammation, all-cause and cardiovascular disease-related mortality in the United States.Effect of culture at low oxygen tension on the expression of heat shock proteins in a panel of melanoma cell lines.T cells and aging, January 2002 update.Enhanced Chemokine Receptor Expression on Leukocytes of Patients with Alzheimer's DiseaseMultiparameter flow cytometric analysis of CD4 and CD8 T cell subsets in young and old peopleProthymosin α and a prothymosin α-derived peptide enhance T(H)1-type immune responses against defined HER-2/neu epitopes.Zinc, oxidative stress, genetic background and immunosenescence: implications for healthy ageing.Escape mechanisms in tumor immunity: an update.Compromised interferon gamma (IFN-gamma) production in the elderly to both acute and latent viral antigen stimulation: contribution to the immune risk phenotype?Pathways to a robust immune response in the elderly.Immunosenescence and human longevity.Relationship between anthropometric variables and nutrient intake in apparently healthy male elderly individuals: a study from PakistanReport from the second cytomegalovirus and immunosenescence workshop.A lack of telomeric non-reciprocal recombination (TENOR) may account for the premature proliferation blockade of Werner's syndrome fibroblasts.Tumour escape: antitumour effectors too much of a good thing?Immunosenescence comes of age. Symposium on Aging Research in Immunology: The Impact of GenomicsRole of persistent CMV infection in configuring T cell immunity in the elderlyImmunotherapy and immunoselection -- tumour escape as the final hurdle.Engineering anticancer T cells for extended functional longevity.Is immunosenescence infectious?The inflammatory markers CRP, IL-6, and IL-10 are associated with cognitive function--data from the Berlin Aging Study II.Defining the critical hurdles in cancer immunotherapy.
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Graham Pawelec
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