about
The chemotherapeutic drug 5-fluorouracil promotes PKR-mediated apoptosis in a p53-independent manner in colon and breast cancer cellsModulation of myogenic differentiation in a human rhabdomyosarcoma cell line by a new derivative of 5-fluorouracil (QF-3602).HER2-signaling pathway, JNK and ERKs kinases, and cancer stem-like cells are targets of Bozepinib small compound.5-Fluorouracil derivatives: a patent review.EMT and EGFR in CTCs cytokeratin negative non-metastatic breast cancerEpigenetic control of retrotransposon expression in human embryonic stem cells.Actual targets in cytodifferentiation cancer therapy.Cadmium influences the 5-Fluorouracil cytotoxic effects on breast cancer cells.Cancer gene therapy: strategies and clinical trials.Inhibition of growth and induction of apoptosis in human breast cancer by transfection of gef gene.Bozepinib, a novel small antitumor agent, induces PKR-mediated apoptosis and synergizes with IFNα triggering apoptosis, autophagy and senescence.Prognostic value of RT-PCR tyrosinase detection in peripheral blood of melanoma patients.Acyclonucleosides, modified seco-nucleosides, and salicyl- or catechol-derived acyclic 5-fluorouracil O,N-acetals: antiproliferative activities, cellular differentiation and apoptosis.Knee Viscosupplementation: Cost-Effectiveness Analysis between Stabilized Hyaluronic Acid in a Single Injection versus Five Injections of Standard Hyaluronic Acid.Resident and non-resident stem cells in acute myocardial infarction.Transdifferentiation: why and how?Nanomedicine: application areas and development prospects.How is gene transfection able to improve current chemotherapy? The role of combined therapy in cancer treatment.Functionalized nanostructures with application in regenerative medicine.The impact of PKR activation: from neurodegeneration to cancer.How Can Nanotechnology Help to Repair the Body? Advances in Cardiac, Skin, Bone, Cartilage and Nerve Tissue RegenerationAnti-proliferative activity of 2,6-dichloro-9- or 7-(ethoxycarbonylmethyl)-9H- or 7H-purines against several human solid tumour cell lines.Enantiospecific synthesis of heterocycles linked to purines: different apoptosis modulation of enantiomers in breast cancer cells.Characterization of different functionalized lipidic nanocapsules as potential drug carriersThe selective cytotoxic activity in breast cancer cells by an anthranilic alcohol-derived acyclic 5-fluorouracil O,N-acetal is mediated by endoplasmic reticulum stress-induced apoptosis.Synthesis and anticancer activity of the (R,S)-benzofused 1,5-oxathiepine moiety tethered to purines through alkylidenoxy linkers.Anticancer activity and cDNA microarray studies of a (RS)-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-yl]-6-chloro-9H-purine, and an acyclic (RS)-O,N-acetalic 6-chloro-7H-purine.Synthesis and anticancer activity of (RS)-9-(2,3-dihydro-1,4-benzoxaheteroin-2-ylmethyl)-9H-purines.New (RS)-benzoxazepin-purines with antitumour activity: The chiral switch from (RS)-2,6-dichloro-9-[1-(p-nitrobenzenesulfonyl)-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]-9H-purine.Differentiation of intestinal epithelial cells mediated by cell confluence and/or exogenous nucleoside supplementation.Cell surface immobilization of GABAA Rs in cerebellar granule cells depends on the M3/M4 cytoplasmatic loop of the alpha 1 subunit.Tumour malignancy loss and cell differentiation are associated with induction of gef gene in human melanoma cells.Anticancer activity of (1,2,3,5-tetrahydro-4,1-benzoxazepine-3-yl)-pyrimidines and -purines against the MCF-7 cell line: Preliminary cDNA microarray studies.Regiospecific microwave-assisted synthesis and cytotoxic activity against human breast cancer cells of (RS)-6-substituted-7- or 9-(2,3-dihydro-5H-1,4-benzodioxepin-3-yl)-7H- or -9H-purines.Synthesis and anticancer activity of (R,S)-9-(2,3-dihydro-1,4-benzoxathiin-3-ylmethyl)-9H-purines.Antiproliferative activity, cell-cycle dysregulation, and cellular differentiation: salicyl- and catechol-derived acyclic 5-fluorouracil O,N-acetals against breast cancer cells.5-fluorouracil derivatives induce differentiation mediated by tubulin and HLA class I modulation.A synthetic uracil derivative with antitumor activity through decreasing cyclin D1 and Cdk1, and increasing p21 and p27 in MCF-7 cells.Modulation of Ki-67 expression and morphological changes induced by gef gene in MCF-7 human breast cancer cells.Antitumoural properties of benzannelated seven-membered 5-fluorouracil derivatives and related open analogues. Molecular markers for apoptosis and cell cycle dysregulation.
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Juan Antonio Marchal
@ast
Juan Antonio Marchal
@en
Juan Antonio Marchal
@es
Juan Antonio Marchal
@nl
Juan Antonio Marchal
@sl
type
label
Juan Antonio Marchal
@ast
Juan Antonio Marchal
@en
Juan Antonio Marchal
@es
Juan Antonio Marchal
@nl
Juan Antonio Marchal
@sl
altLabel
J.A. Marchal Corrales
@en
Juan Antonio Marchal Corrales
@en
Juan Antonio Marchal
@en
prefLabel
Juan Antonio Marchal
@ast
Juan Antonio Marchal
@en
Juan Antonio Marchal
@es
Juan Antonio Marchal
@nl
Juan Antonio Marchal
@sl
P1053
M-4305-2014
P106
P1153
35511243200
55043224900
P21
P31
P3829
P496
0000-0002-4996-8261