Killing me softly: chlamydial use of proteolysis for evading host defenses.
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A path forward for the chlamydial virulence factor CPAFActin recruitment to the Chlamydia inclusion is spatiotemporally regulated by a mechanism that requires host and bacterial factorsIn contrast to Chlamydia trachomatis, Waddlia chondrophila grows in human cells without inhibiting apoptosis, fragmenting the Golgi apparatus, or diverting post-Golgi sphingomyelin transportInduction of protective immunity against Chlamydia muridarum intravaginal infection with a chlamydial glycogen phosphorylaseIntegrating chemical mutagenesis and whole-genome sequencing as a platform for forward and reverse genetic analysis of Chlamydia.Reassessing the role of the secreted protease CPAF in Chlamydia trachomatis infection through genetic approachesCyclic regulation of apoptotic gene expression in the mouse oviduct.Heat denatured enzymatically inactive recombinant chlamydial protease-like activity factor induces robust protective immunity against genital chlamydial challengeThe chlamydial periplasmic stress response serine protease cHtrA is secreted into host cell cytosolTargeting of a chlamydial protease impedes intracellular bacterial growthEnhanced upper genital tract pathologies by blocking Tim-3 and PD-L1 signaling pathways in mice intravaginally infected with Chlamydia muridarum.Characterization of Pgp3, a Chlamydia trachomatis plasmid-encoded immunodominant antigenCPAF: a Chlamydial protease in search of an authentic substrate.Cleavage of the NF-κB family protein p65/RelA by the chlamydial protease-like activity factor (CPAF) impairs proinflammatory signaling in cells infected with ChlamydiaeSecretion of the chlamydial virulence factor CPAF requires the Sec-dependent pathwayChlamydia trachomatis GlgA is secreted into host cell cytoplasm.Chlamydia trachomatis secretion of proteases for manipulating host signaling pathways.Localization of Chlamydia trachomatis hypothetical protein CT311 in host cell cytoplasm.A Chlamydia trachomatis OmcB C-terminal fragment is released into the host cell cytoplasm and is immunogenic in humansChlamydia trachomatis secretion of an immunodominant hypothetical protein (CT795) into host cell cytoplasm.Chlamydia trachomatis secretion of hypothetical protein CT622 into host cell cytoplasm via a secretion pathway that can be inhibited by the type III secretion system inhibitor compound 1.The Chlamydia protease CPAF regulates host and bacterial proteins to maintain pathogen vacuole integrity and promote virulenceGolgi fragmentation and sphingomyelin transport to Chlamydia trachomatis during penicillin-induced persistence do not depend on the cytosolic presence of the chlamydial protease CPAFImmunity and vaccines against sexually transmitted Chlamydia trachomatis infectionProtective immunity against mouse upper genital tract pathology correlates with high IFNγ but low IL-17 T cell and anti-secretion protein antibody responses induced by replicating chlamydial organisms in the airway.Identification of antigen-specific antibody responses associated with upper genital tract pathology in mice infected with Chlamydia muridarum.Chlamydia trachomatis outer membrane complex protein B (OmcB) is processed by the protease CPAF.The Chlamydia-Secreted Protease CPAF Promotes Chlamydial Survival in the Mouse Lower Genital TractExpression and targeting of secreted proteins from Chlamydia trachomatis.Background review for the '2015 European guideline on the management of Chlamydia trachomatis infections'.Induction and inhibition of CPAF activity during analysis of Chlamydia-infected cells.The Chlamydia protease CPAF: caution, precautions and function.Analysis of CPAF mutants: new functions, new questions (the ins and outs of a chlamydial protease).Recent advances in Chlamydia subversion of host cytoskeletal and membrane trafficking pathways.A neuro-immune model of Myalgic Encephalomyelitis/Chronic fatigue syndrome.Chlamydia trachomatis: The persistent pathogen.Association of asymptomatic Chlamydia trachomatis infection with male infertility and the effect of antibiotic therapy in improvement of semen quality in infected infertile men.Parasitic aphrodisiacs: manipulation of the hosts' behavioral defenses by sexually transmitted parasites.Seroprevalence and risk factors of Chlamydia abortus infection in Tibetan sheep in Gansu province, northwest China
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P2860
Killing me softly: chlamydial use of proteolysis for evading host defenses.
description
article científic
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article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 16 September 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Killing me softly: chlamydial use of proteolysis for evading host defenses.
@en
Killing me softly: chlamydial use of proteolysis for evading host defenses.
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type
label
Killing me softly: chlamydial use of proteolysis for evading host defenses.
@en
Killing me softly: chlamydial use of proteolysis for evading host defenses.
@nl
prefLabel
Killing me softly: chlamydial use of proteolysis for evading host defenses.
@en
Killing me softly: chlamydial use of proteolysis for evading host defenses.
@nl
P2860
P1476
Killing me softly: chlamydial use of proteolysis for evading host defenses.
@en
P2093
Guangming Zhong
P2860
P304
P356
10.1016/J.TIM.2009.07.007
P577
2009-09-16T00:00:00Z