Characterization of phospholipase C gamma enzymes with gain-of-function mutations. - Wikidata - awgldk - TriplyDB

Characterization of phospholipase C gamma enzymes with gain-of-function mutations.

Characterization of phospholipase C gamma enzymes with gain-of-function mutations.

http://www.wikidata.org/entity/Q37371736

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A protease-independent function for SPPL3 in NFAT activation Phosphoinositides: tiny lipids with giant impact on cell regulation Structural and Functional Integration of the PLCγ Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation Autoinhibition and Phosphorylation-Induced Activation of Phospholipase C-γ Isozymes Protein Kinase C δ: a Gatekeeper of Immune Homeostasis Order and disorder in large multi-site docking proteins of the Gab family--implications for signalling complex formation and inhibitor design strategies The autoinhibitory C-terminal SH2 domain of phospholipase C-γ2 stabilizes B cell receptor signalosome assembly.Recurrent PTPRB and PLCG1 mutations in angiosarcoma.Immunological loss-of-function due to genetic gain-of-function in humans: autosomal dominance of the third kind Cross-talk between phospho-STAT3 and PLCγ1 plays a critical role in colorectal tumorigenesis.Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions.A hypermorphic missense mutation in PLCG2, encoding phospholipase Cγ2, causes a dominantly inherited autoinflammatory disease with immunodeficiency.Two FGF Receptor Kinase Molecules Act in Concert to Recruit and Transphosphorylate Phospholipase Cγ Membrane environment exerts an important influence on rac-mediated activation of phospholipase Cγ2.Protein kinase D at the Golgi controls NLRP3 inflammasome activation.Stromal cell-derived factor-1 signaling via the CXCR4-TCR heterodimer requires phospholipase C-β3 and phospholipase C-γ1 for distinct cellular responses.The Phospholipase Cγ2 Mutants R665W and L845F Identified in Ibrutinib-resistant Chronic Lymphocytic Leukemia Patients Are Hypersensitive to the Rho GTPase Rac2 Protein.Platelet hyperreactivity and a prothrombotic phenotype in mice with a gain-of-function mutation in phospholipase Cgamma2.Venetoclax for chronic lymphocytic leukaemia progressing after ibrutinib: an interim analysis of a multicentre, open-label, phase 2 trial.Galpha(q) and phospholipase C-beta: turn on, turn off, and do it fast.Role of amplification in phospholipase Cγ2 activation in modulation of gastric mucosal inflammatory responses to Helicobacter pylori: effect of ghrelin.A novel N-ethyl-N-nitrosourea-induced mutation in phospholipase Cγ2 causes inflammatory arthritis, metabolic defects, and male infertility in vitro in a murine model Dynamic Allostery in PLCγ1 and Its Modulation by a Cancer Mutation Revealed by MD Simulation and NMR Functional characterization of phospholipase C-γ mutant protein causing both somatic ibrutinib resistance and a germline monogenic autoinflammatory disorder

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Characterization of phospholipase C gamma enzymes with gain-of-function mutations.

http://www.wikidata.org/entity/Q37371736

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

@pt

bilimsel makale

@tr

scientific article published on 16 June 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Characterization of phospholipase C gamma enzymes with gain-of-function mutations.

@en

Characterization of phospholipase C gamma enzymes with gain-of-function mutations.

@nl

type

label

Characterization of phospholipase C gamma enzymes with gain-of-function mutations.

@en

Characterization of phospholipase C gamma enzymes with gain-of-function mutations.

@nl

prefLabel

Characterization of phospholipase C gamma enzymes with gain-of-function mutations.

@en

Characterization of phospholipase C gamma enzymes with gain-of-function mutations.

@nl

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JBC.M109.019265

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Journal of Biological Chemistry

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Characterization of phospholipase C gamma enzymes with gain-of-function mutations.

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Fernando Rodrigues-Lima

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Helmut Fuchs

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Katy L Everett

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Koichiro Abe

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Matilda Katan

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Philipp Yu

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Richard Harris

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Wohnwa Cho

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Youngdae Yoon

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P2860

Solution structure of the SH3 domain of phospholipase C-gamma

Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-gamma 1 complexed with a high affinity binding peptide

Elevated content of the tyrosine kinase substrate phospholipase C-gamma 1 in primary human breast carcinomas

General and Versatile Autoinhibition of PLC Isozymes

Rac Regulates Its Effector Phospholipase C 2 through Interaction with a Split Pleckstrin Homology Domain

Structural insights into formation of an active signaling complex between Rac and phospholipase C gamma 2

Crystal structure of a mammalian phosphoinositide-specific phospholipase C delta

AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR

Phospholipase Cgamma1 is required for metastasis development and progression

Multiple roles of phosphoinositide-specific phospholipase C isozymes

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23083-23093

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10.1074/JBC.M109.019265

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Martin Hrabě de Angelis

Paul C. Driscoll

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2009-06-16T00:00:00Z

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