Comparison of EJC-enhanced and EJC-independent NMD in human cells reveals two partially redundant degradation pathways
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Nonsense-mediated mRNA decay: novel mechanistic insights and biological impactProteins involved in the degradation of cytoplasmic mRNA in the major eukaryotic model systemsNonsense-mediated mRNA decay: inter-individual variability and human diseaseRetroviral strategy to stabilize viral RNAThe RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation.Mutations in SMG9, Encoding an Essential Component of Nonsense-Mediated Decay Machinery, Cause a Multiple Congenital Anomaly Syndrome in Humans and MiceFunction and pathological implications of exon junction complex factor Y14Spliceosomal protein eftud2 mutation leads to p53-dependent apoptosis in zebrafish neural progenitors.A novel phosphorylation-independent interaction between SMG6 and UPF1 is essential for human NMD.Identification of SMG6 cleavage sites and a preferred RNA cleavage motif by global analysis of endogenous NMD targets in human cells.The unfolded protein response is shaped by the NMD pathwayFUS/TLS contributes to replication-dependent histone gene expression by interaction with U7 snRNPs and histone-specific transcription factorsA critical role of RBM8a in proliferation and differentiation of embryonic neural progenitors.The role of nucleotide composition in premature termination codon recognition.Recent transcriptome-wide mapping of UPF1 binding sites reveals evidence for its recruitment to mRNA before translation.Human nonsense-mediated mRNA decay factor UPF2 interacts directly with eRF3 and the SURF complexTranscriptome-wide identification of NMD-targeted human mRNAs reveals extensive redundancy between SMG6- and SMG7-mediated degradation pathways.Therapeutics based on stop codon readthrough.In vivo determination of direct targets of the nonsense-mediated decay pathway in Drosophila.An atlas of chromatoid body componentsRegulation of natural mRNAs by the nonsense-mediated mRNA decay pathway.Mechanism, factors, and physiological role of nonsense-mediated mRNA decay.Nonsense-mediated mRNA decay: an intricate machinery that shapes transcriptomes.A novel role for CARM1 in promoting nonsense-mediated mRNA decay: potential implications for spinal muscular atrophy.Resistance of mRNAs with AUG-proximal nonsense mutations to nonsense-mediated decay reflects variables of mRNA structure and translational activity.A Role for the Nonsense-Mediated mRNA Decay Pathway in Maintaining Genome Stability in Caenorhabditis elegans.Nonsense-mediated mRNA decay at the crossroads of many cellular pathwaysSynonymous codon usage affects the expression of wild type and F508del CFTR.Regulation of gene expression by translation factor eIF5A: Hypusine-modified eIF5A enhances nonsense-mediated mRNA decay in human cells.The SMG5-SMG7 heterodimer directly recruits the CCR4-NOT deadenylase complex to mRNAs containing nonsense codons via interaction with POP2.Stop that nonsense!A Upf3b-mutant mouse model with behavioral and neurogenesis defects.mRNAs containing NMD-competent premature termination codons are stabilized and translated under UPF1 depletion.Directed hydroxyl radical probing reveals Upf1 binding to the 80S ribosomal E site rRNA at the L1 stalk.CRISPR-Trap: a clean approach for the generation of gene knockouts and gene replacements in human cells.Dissecting the functions of SMG5, SMG7 and PNRC2 in nonsense-mediated mRNA decay of human cells.Antisense suppression of the nonsense mediated decay factor Upf3b as a potential treatment for diseases caused by nonsense mutations.Nonsense-mediated mRNA decay: a 'nonsense' pathway makes sense in stem cell biology.Nonsense in the testis: multiple roles for nonsense-mediated decay revealed in male reproduction.ICE1 promotes the link between splicing and nonsense-mediated mRNA decay.
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Comparison of EJC-enhanced and EJC-independent NMD in human cells reveals two partially redundant degradation pathways
description
article científic
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article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 20 August 2013
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Comparison of EJC-enhanced and ...... redundant degradation pathways
@en
Comparison of EJC-enhanced and ...... edundant degradation pathways.
@nl
type
label
Comparison of EJC-enhanced and ...... redundant degradation pathways
@en
Comparison of EJC-enhanced and ...... edundant degradation pathways.
@nl
prefLabel
Comparison of EJC-enhanced and ...... redundant degradation pathways
@en
Comparison of EJC-enhanced and ...... edundant degradation pathways.
@nl
P2093
P2860
P356
P1433
P1476
Comparison of EJC-enhanced and ...... redundant degradation pathways
@en
P2093
Marc-David Ruepp
Stefanie Metze
Veronika A Herzog
P2860
P304
P356
10.1261/RNA.038893.113
P407
P577
2013-08-20T00:00:00Z