The natural product honokiol preferentially inhibits cellular FLICE-inhibitory protein and augments death receptor-induced apoptosis.
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Antitumor Activity of 2,9-Di-Sec-Butyl-1,10-PhenanthrolineThe eIF4E/eIF4G interaction inhibitor 4EGI-1 augments TRAIL-mediated apoptosis through c-FLIP Down-regulation and DR5 induction independent of inhibition of cap-dependent protein translationThe NEDD8-activating enzyme inhibitor, MLN4924, cooperates with TRAIL to augment apoptosis through facilitating c-FLIP degradation in head and neck cancer cellsHonokiol traverses the blood-brain barrier and induces apoptosis of neuroblastoma cells via an intrinsic bax-mitochondrion-cytochrome c-caspase protease pathway.The novel Akt inhibitor API-1 induces c-FLIP degradation and synergizes with TRAIL to augment apoptosis independent of Akt inhibition.Honokiol bis-dichloroacetate (Honokiol DCA) demonstrates activity in vemurafenib-resistant melanoma in vivoZerumbone enhances TRAIL-induced apoptosis through the induction of death receptors in human colon cancer cells: Evidence for an essential role of reactive oxygen species.Honokiol inhibits EMT-mediated motility and migration of human non-small cell lung cancer cells in vitro by targeting c-FLIP.Honokiol analogs: a novel class of anticancer agents targeting cell signaling pathways and other bioactivities.The BET bromodomain inhibitor, JQ1, facilitates c-FLIP degradation and enhances TRAIL-induced apoptosis independent of BRD4 and c-Myc inhibition.Celecoxib promotes c-FLIP degradation through Akt-independent inhibition of GSK3.Inhibition of Akt signaling by the lignan matairesinol sensitizes prostate cancer cells to TRAIL-induced apoptosis.Honokiol suppresses proliferation and induces apoptosis via regulation of the miR‑21/PTEN/PI3K/AKT signaling pathway in human osteosarcoma cells.
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P2860
The natural product honokiol preferentially inhibits cellular FLICE-inhibitory protein and augments death receptor-induced apoptosis.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on July 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The natural product honokiol p ...... th receptor-induced apoptosis.
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The natural product honokiol p ...... th receptor-induced apoptosis.
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type
label
The natural product honokiol p ...... th receptor-induced apoptosis.
@en
The natural product honokiol p ...... th receptor-induced apoptosis.
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prefLabel
The natural product honokiol p ...... th receptor-induced apoptosis.
@en
The natural product honokiol p ...... th receptor-induced apoptosis.
@nl
P2093
P2860
P1476
The natural product honokiol p ...... ath receptor-induced apoptosis
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P2093
Benjamin Lefkove
Fadlo R Khuri
Jack L Arbiser
Shi-Yong Sun
Shruti M Raja
Timothy M Acker
P2860
P304
P356
10.1158/1535-7163.MCT-07-2409
P577
2008-07-01T00:00:00Z