Mice heterozygous for germ-line mutations in methylthioadenosine phosphorylase (MTAP) die prematurely of T-cell lymphoma.
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Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutationsStructural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzymeEffect of 9p21.3 coronary artery disease locus neighboring genes on atherosclerosis in miceS-adenosylmethionine in liver health, injury, and cancer.Collateral Lethality: A new therapeutic strategy in oncologyGrowth and metastases of human lung cancer are inhibited in mouse xenografts by a transition state analogue of 5'-methylthioadenosine phosphorylase.Multigenic nature of the mouse pulmonary adenoma progression 1 locusGermline Mutations in Mtap Cooperate with Myc to Accelerate Tumorigenesis in MiceExpression of MTAP inhibits tumor-related phenotypes in HT1080 cells via a mechanism unrelated to its enzymatic function.Downregulated MTAP expression in myxofibrosarcoma: A characterization of inactivating mechanisms, tumor suppressive function, and therapeutic relevance.Strategic approaches to unraveling genetic causes of cardiovascular diseases.Methylthioadenosine phosphorylase (MTAP)-deficient T-cell ALL xenografts are sensitive to pralatrexate and 6-thioguanine alone and in combination.Methylthioadenosine (MTA) Regulates Liver Cells Proteome and Methylproteome: Implications in Liver Biology and DiseaseThe MTAP-CDKN2A locus confers susceptibility to a naturally occurring canine cancer.Targeting tumors that lack methylthioadenosine phosphorylase (MTAP) activity: current strategiesModelling melanoma in mice.Suppressive effects of tumor cell-derived 5'-deoxy-5'-methylthioadenosine on human T cellsIncreasing the therapeutic index of 5-fluorouracil and 6-thioguanine by targeting loss of MTAP in tumor cells.Polyamine production is downstream and upstream of oncogenic PI3K signalling and contributes to tumour cell growth.[Detection of MTAP protein and gene expression in non-small cell lung cancer].
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P2860
Mice heterozygous for germ-line mutations in methylthioadenosine phosphorylase (MTAP) die prematurely of T-cell lymphoma.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 30 June 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Mice heterozygous for germ-lin ...... rematurely of T-cell lymphoma.
@en
Mice heterozygous for germ-line mutations in methylthioadenosine phosphorylase
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type
label
Mice heterozygous for germ-lin ...... rematurely of T-cell lymphoma.
@en
Mice heterozygous for germ-line mutations in methylthioadenosine phosphorylase
@nl
prefLabel
Mice heterozygous for germ-lin ...... rematurely of T-cell lymphoma.
@en
Mice heterozygous for germ-line mutations in methylthioadenosine phosphorylase
@nl
P2093
P2860
P1433
P1476
Mice heterozygous for germ-lin ...... rematurely of T-cell lymphoma.
@en
P2093
Andres Klein-Szanto
Baiqing Tang
Craig H Bassing
Eoin P Quinlivan
Richard R Hardy
Susan A Shinton
Tahseen I Al-Saleem
Warren D Kruger
P2860
P304
P356
10.1158/0008-5472.CAN-09-0145
P407
P577
2009-06-30T00:00:00Z