Epac activates the small G proteins Rap1 and Rab3A to achieve exocytosis - Wikidata - awgldk - TriplyDB

Epac activates the small G proteins Rap1 and Rab3A to achieve exocytosis

Epac activates the small G proteins Rap1 and Rab3A to achieve exocytosis

http://www.wikidata.org/entity/Q37375655

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Molecular mechanism for human sperm chemotaxis mediated by progesterone Multiple roles for the actin cytoskeleton during regulated exocytosis Distinct initial SNARE configurations underlying the diversity of exocytosis ADP ribosylation factor 6 (ARF6) promotes acrosomal exocytosis by modulating lipid turnover and Rab3A activation.Ca2+ signals generated by CatSper and Ca2+ stores regulate different behaviors in human sperm.Unresolved questions concerning mammalian sperm acrosomal exocytosis.Signaling in sperm: toward a molecular understanding of the acquisition of sperm motility in the mouse epididymis.α-SNAP prevents docking of the acrosome during sperm exocytosis because it sequesters monomeric syntaxin.beta-Adrenergic activation of electrogenic K+ and Cl- secretion in guinea pig distal colonic epithelium proceeds via separate cAMP signaling pathways.Calcium channels in the development, maturation, and function of spermatozoa.Epac, Rap and Rab3 act in concert to mobilize calcium from sperm's acrosome during exocytosis cAMP and EPAC are key players in the regulation of the signal transduction pathway involved in the α-hemolysin autophagic response Identification and function of exchange proteins activated directly by cyclic AMP (Epac) in mammalian spermatozoa.Central role of soluble adenylyl cyclase and cAMP in sperm physiology.Cannabinoid type 1 receptors transiently silence glutamatergic nerve terminals of cultured cerebellar granule cells.Epac2 Mediates cAMP-Dependent Potentiation of Neurotransmission in the Hippocampus.Heads or tails? Structural events and molecular mechanisms that promote mammalian sperm acrosomal exocytosis and motility.cAMP-mediated secretion of brain-derived neurotrophic factor in developing airway smooth muscle.Identification and Localization of the Cyclic Nucleotide Phosphodiesterase 10A in Bovine Testis and Mature Spermatozoa.Activation of soluble adenylyl cyclase protects against secretagogue stimulated zymogen activation in rat pancreaic acinar cells Rab27 and Rab3 sequentially regulate human sperm dense-core granule exocytosis β-Adrenergic receptors activate exchange protein directly activated by cAMP (Epac), translocate Munc13-1, and enhance the Rab3A-RIM1α interaction to potentiate glutamate release at cerebrocortical nerve terminals.Compartmentalization of distinct cAMP signaling pathways in mammalian sperm Roles of intracellular cyclic AMP signal transduction in the capacitation and subsequent hyperactivation of mouse and boar spermatozoa Adenylyl cyclases in the digestive system.The proteins of exocytosis: lessons from the sperm model.The Molecules of Sperm Exocytosis.A strong host response and lack of MYC expression are characteristic for diffuse large B cell lymphoma transformed from nodular lymphocyte predominant Hodgkin lymphoma Cellular mechanisms of plasmalemmal sealing and axonal repair by polyethylene glycol and methylene blue.Pathways for plasmalemmal repair mediated by PKA, Epac, and cytosolic oxidation in rat B104 cells in vitro and rat sciatic axons ex vivo.Identification of EPAC (Exchange Protein Activated by cAMP) bioinformatically as a potential signalling biomarker in Cardiovascular Disease (CVD) and its molecular docking by a lead molecule.The dynamic plasticity of insulin production in β-cells.GTP-bound Rab3A exhibits consecutive positive and negative roles during human sperm dense-core granule exocytosis.The Rab3A-22A Chimera Prevents Sperm Exocytosis by Stabilizing Open Fusion Pores.Rab3a-Bound CD63 Is Degraded and Rab3a-Free CD63 Is Incorporated into HIV-1 Particles.CB1 receptors down-regulate a cAMP/Epac2/PLC pathway to silence the nerve terminals of cerebellar granule cells.Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development.Inhibition of Epac2 Attenuates Neural Cell Apoptosis and Improves Neurological Deficits in a Rat Model of Traumatic Brain Injury.How Rap and its GEFs control liver physiology and cancer development. C3G alterations in human hepatocarcinoma

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Epac activates the small G proteins Rap1 and Rab3A to achieve exocytosis

http://www.wikidata.org/entity/Q37375655

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 22 June 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Epac activates the small G proteins Rap1 and Rab3A to achieve exocytosis

@en

Epac activates the small G proteins Rap1 and Rab3A to achieve exocytosis.

@nl

type

label

Epac activates the small G proteins Rap1 and Rab3A to achieve exocytosis

@en

Epac activates the small G proteins Rap1 and Rab3A to achieve exocytosis.

@nl

prefLabel

Epac activates the small G proteins Rap1 and Rab3A to achieve exocytosis

@en

Epac activates the small G proteins Rap1 and Rab3A to achieve exocytosis.

@nl

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JBC.M109.015362

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Journal of Biological Chemistry

P1476

Epac activates the small G proteins Rap1 and Rab3A to achieve exocytosis

@en

P2093

Alberto Darszon

http://www.w3.org/2001/XMLSchema#string

Claudia N Tomes

http://www.w3.org/2001/XMLSchema#string

Gerardo A De Blas

http://www.w3.org/2001/XMLSchema#string

Holger Rehmann

http://www.w3.org/2001/XMLSchema#string

Luis S Mayorga

http://www.w3.org/2001/XMLSchema#string

María T Branham

http://www.w3.org/2001/XMLSchema#string

Matías A Bustos

http://www.w3.org/2001/XMLSchema#string

Valeria E P Zarelli

http://www.w3.org/2001/XMLSchema#string

P2860

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

A family of cAMP-binding proteins that directly activate Rap1

Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs

Kinetic properties of "soluble" adenylyl cyclase. Synergism between calcium and bicarbonate

Control of vesicle fusion by a tyrosine phosphatase

Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B

Molecular details of cAMP generation in mammalian cells: a tale of two systems

Calcium-triggered acrosomal exocytosis in human spermatozoa requires the coordinated activation of Rab3A and N-ethylmaleimide-sensitive factor

Selective coupling of type 6 adenylyl cyclase with type 2 IP3 receptors mediates direct sensitization of IP3 receptors by cAMP

Dynamics of SNARE assembly and disassembly during sperm acrosomal exocytosis

P304

24825-24839

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scholarly article

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10.1074/JBC.M109.015362

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P407

P433

37

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284

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Claudia L Treviño

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2009-06-22T00:00:00Z

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19546222

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2757186

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