about
Intrinsically unstructured domain 3 of hepatitis C Virus NS5A forms a "fuzzy complex" with VAPB-MSP domain which carries ALS-causing mutationsTyrosine phosphorylation of the well packed ephrinB cytoplasmic beta-hairpin for reverse signaling. Structural consequences and binding propertiesStructural insight into the binding diversity between the Tyr-phosphorylated human ephrinBs and Nck2 SH2 domainThe variable N-terminal region of DDX5 contains structural elements and auto-inhibits its interaction with NS5B of hepatitis C virusStructural insight into the binding diversity between the human Nck2 SH3 domains and proline-rich proteinsNogo goes in the pure water: solution structure of Nogo-60 and design of the structured and buffer-soluble Nogo-54 for enhancing CNS regenerationMechanism for Controlling the Dimer-Monomer Switch and Coupling Dimerization to Catalysis of the Severe Acute Respiratory Syndrome Coronavirus 3C-Like ProteaseCrystal Structure and NMR Binding Reveal That Two Small Molecule Antagonists Target the High Affinity Ephrin-binding Channel of the EphA4 ReceptorStructural Characterization of the EphA4-Ephrin-B2 Complex Reveals New Features Enabling Eph-Ephrin Binding PromiscuityStructure of the Arabidopsis thaliana DCL4 DUF283 domain reveals a noncanonical double-stranded RNA-binding fold for protein-protein interactionElimination of the native structure and solubility of the hVAPB MSP domain by the Pro56Ser mutation that causes amyotrophic lateral sclerosisNMR binding and crystal structure reveal that intrinsically-unstructured regulatory domain auto-inhibits PAK4 by a mechanism different from that of PAK1Mechanism for transforming cytosolic SOD1 into integral membrane proteins of organelles by ALS-causing mutationsOn the convergent evolution of animal toxins. Conservation of a diad of functional residues in potassium channel-blocking toxins with unrelated structuresNMR solution structure of a two-disulfide derivative of charybdotoxin: structural evidence for conservation of scorpion toxin alpha/beta motif and its hydrophobic side chain packingSolution structure and backbone dynamics of the functional cytoplasmic subdomain of human ephrin B2, a cell-surface ligand with bidirectional signaling propertiesStructural characterization of the human Nogo-A functional domains. Solution structure of Nogo-40, a Nogo-66 receptor antagonist enhancing injured spinal cord regenerationThe N- and C-termini of the human Nogo molecules are intrinsically unstructured: bioinformatics, CD, NMR characterization, and functional implicationsIdentification and structural mechanism for a novel interaction between a ubiquitin ligase WWP1 and Nogo-A, a key inhibitor for central nervous system regenerationNogo-B receptor possesses an intrinsically unstructured ectodomain and a partially folded cytoplasmic domainA model of dynamic side-chain--side-chain interactions in the alpha-lactalbumin molten globuleInsights into protein aggregation by NMR characterization of insoluble SH3 mutants solubilized in salt-free waterDynamically-driven inactivation of the catalytic machinery of the SARS 3C-like protease by the N214A mutation on the extra domainStructural, stability, dynamic and binding properties of the ALS-causing T46I mutant of the hVAPB MSP domain as revealed by NMR and MD simulationsNMR and MD Studies Reveal That the Isolated Dengue NS3 Protease Is an Intrinsically Disordered Chymotrypsin Fold Which Absolutely Requests NS2B for Correct Folding and Functional DynamicsC-Terminal Auto-Regulatory Motif of Hepatitis C Virus NS5B Interacts with Human VAPB-MSP to Form a Dynamic Replication ComplexStructural study of hNck2 SH3 domain protein in solution by circular dichroism and X-ray solution scattering.SALS-linked WT-SOD1 adopts a highly similar helical conformation as FALS-causing L126Z-SOD1 in a membrane environment.VAPC, an human endogenous inhibitor for hepatitis C virus (HCV) infection, is intrinsically unstructured but forms a "fuzzy complex" with HCV NS5B.NMR evidence for forming highly populated helical conformations in the partially folded hNck2 SH3 domain.Insoluble protein characterization by circular dichroism (CD) spectroscopy and nuclear magnetic resonance (NMR).Resurrecting abandoned proteins with pure water: CD and NMR studies of protein fragments solubilized in salt-free water.Transforming Cytosolic Proteins into "Insoluble" and Membrane-toxic Forms by Genetic, Pathological or Environmental Factors.Disruption of FAT10-MAD2 binding inhibits tumor progression.Insight into "insoluble proteins" with pure water.Structural characterization reveals that viperin is a radical S-adenosyl-L-methionine (SAM) enzyme.RRM domain of ALS/FTD-causing FUS characteristic of irreversible unfolding spontaneously self-assembles into amyloid fibrils.Solution conformations of Zika NS2B-NS3pro and its inhibition by natural products from edible plantsDynamically-driven enhancement of the catalytic machinery of the SARS 3C-like protease by the S284-T285-I286/A mutations on the extra domain.Selective and specific ion binding on proteins at physiologically-relevant concentrations.
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Jianxing Song
@ast
Jianxing Song
@en
Jianxing Song
@es
Jianxing Song
@nl
Jianxing Song
@sl
type
label
Jianxing Song
@ast
Jianxing Song
@en
Jianxing Song
@es
Jianxing Song
@nl
Jianxing Song
@sl
prefLabel
Jianxing Song
@ast
Jianxing Song
@en
Jianxing Song
@es
Jianxing Song
@nl
Jianxing Song
@sl
P106
P31
P496
0000-0003-0224-6322
P569
2000-01-01T00:00:00Z