Bone morphogenetic protein signaling is impaired in an HFE knockout mouse model of hemochromatosis. - Wikidata - awgldk - TriplyDB

Bone morphogenetic protein signaling is impaired in an HFE knockout mouse model of hemochromatosis.

Bone morphogenetic protein signaling is impaired in an HFE knockout mouse model of hemochromatosis.

http://www.wikidata.org/entity/Q37376502

about

Hemojuvelin and bone morphogenetic protein (BMP) signaling in iron homeostasis HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice Hepcidin: regulation of the master iron regulator Murine mutants in the study of systemic iron metabolism and its disorders: an update on recent advances The role of TMPRSS6/matriptase-2 in iron regulation and anemia Modulation of hepcidin as therapy for primary and secondary iron overload disorders: preclinical models and approaches Molecular basis of HFE-hemochromatosis.Iron regulation by hepcidin Bmp6 regulates retinal iron homeostasis and has altered expression in age-related macular degeneration Pathways for the regulation of hepcidin expression in anemia of chronic disease and iron deficiency anemia in vivo Iron-regulatory gene expression during liver regeneration Hepcidin and sports anemia Iron at the interface of immunity and infection.Therapeutic effects of induced pluripotent stem cells in chimeric mice with β-thalassemia.Molecular mechanisms of hepcidin regulation: implications for the anemia of CKD.MicroRNA-130a is up-regulated in mouse liver by iron deficiency and targets the bone morphogenetic protein (BMP) receptor ALK2 to attenuate BMP signaling and hepcidin transcription.Effect of iron overload and iron deficiency on liver hemojuvelin protein Hepcidin induction by transgenic overexpression of Hfe does not require the Hfe cytoplasmic tail, but does require hemojuvelin.Transferrin is a major determinant of hepcidin expression in hypotransferrinemic mice Iron and inflammation - the gut reaction.Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice A strong anti-inflammatory signature revealed by liver transcription profiling of Tmprss6-/- mice.Tmprss6 is a genetic modifier of the Hfe-hemochromatosis phenotype in mice.The bone morphogenetic protein-hepcidin axis as a therapeutic target in inflammatory bowel disease Regulation of TMPRSS6 by BMP6 and iron in human cells and mice.Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats Hereditary hemochromatosis and transferrin receptor 2 BMP6 treatment compensates for the molecular defect and ameliorates hemochromatosis in Hfe knockout mice.Transgenic HFE-dependent induction of hepcidin in mice does not require transferrin receptor-2.Modeling the dynamics of mouse iron body distribution: hepcidin is necessary but not sufficient Iron regulation of hepcidin despite attenuated Smad1,5,8 signaling in mice without transferrin receptor 2 or Hfe Unraveling mechanisms regulating systemic iron homeostasis.Transforming Growth Factor β1 (TGF-β1) Activates Hepcidin mRNA Expression in Hepatocytes Out of balance--systemic iron homeostasis in iron-related disorders Expression and function of iron-regulatory proteins in retina.The liver: conductor of systemic iron balance.The iron cycle in chronic kidney disease (CKD): from genetics and experimental models to CKD patients.Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling.

P2860

Q21129271-44597FD7-DAA2-4FEB-B8E4-FE7F82C4BAD9 Q24298843-28B66CE1-952C-4D32-9DEE-4C899883EA8C Q24628683-19189E8D-FF22-4AD9-8A21-F6B5F4F03C49 Q26800198-68F4FAD0-66B4-45B3-9969-4664E108EDB5 Q27009565-EA7F0E99-137C-4965-B3C5-45F167752F93 Q27013874-A9120C25-A2C2-4563-BA57-1AF79C6394D3 Q27027657-B836039C-EE53-4FA4-9EC2-50B70A47B085 Q27687811-9C76D45E-7EA9-4109-973B-9B319C2341EB Q28291718-E23F3B38-2C64-4CCD-960C-7AD0FF7D23BF Q28512223-5FF38C9A-EDCF-4126-8621-855E28E51CBB Q28577508-51C08D69-9A7B-4397-8E97-28A27F3134D9 Q28578994-31EAF221-622B-4332-AEDF-AADABDBBCC28 Q33559763-F33558B4-14EA-4C9C-93C3-1675E61A539B Q33909430-E070FD50-30B1-4FE6-8E6F-9FD5F948FA9D Q33978886-2DD11DEC-115F-400B-9F9A-1F69B1B244E8 Q33999246-ABD382B6-9FA2-439E-8860-12D6D16C4CE1 Q34141088-7B233FFD-1FCB-4DE8-BD70-21737654573A Q34281862-5DB8BAE8-6AF7-4C78-B811-4F63FFB5224F Q34541753-B0D45903-F2D9-4E81-95AD-67B24E15B0EC Q34542137-A02E25CA-E22E-4E32-9DCE-6D3A427C64B4 Q34548797-51E8C5ED-CBCE-4F2C-BBCD-D1713A47F919 Q34783878-84B6A025-DED3-4C5D-AAB6-6BA556EE7A44 Q34903557-9D5DE2AD-B4AC-4DEA-BF13-04FCED506007 Q34997731-082386E9-2B18-44F8-ACCC-F28E9BFAA861 Q35116191-5B3439D8-2AC7-4750-B658-15312F37DB2D Q35125938-7FECCC5D-BAFE-49C0-B99C-4A64D9863CB8 Q35483789-7DC5B5B0-C619-4B52-AB66-5F9515DC29F4 Q35525651-492987C8-DFAE-45F3-81EE-45EA4D5108B4 Q35603164-46C9019B-5E32-416C-A869-39EF4D35BA1D Q35807384-85FB3EA3-987B-4CD4-AD66-22A115E08CF5 Q36067487-B25180C0-43E5-4780-ABEF-182E900960F0 Q36375897-965AE5B4-4F5C-49EC-9B2A-480B7FF55636 Q36790028-A3AFE408-D0FC-404F-A4AD-82FF648B083C Q36828496-80AF886D-F667-4F18-9098-EF277D32F78D Q37065891-236DDF63-D6BE-4DAC-9EE4-FF76B8F5B2DC Q37177398-5822A3B4-7A75-4807-8EB6-E8B8C8B39D7C Q37212477-D0190DFD-4474-4432-845A-F004A9414327 Q37464105-B6AE2A63-7CC7-4C79-8A1D-CD0549C3FBA3 Q37542851-301779A0-8023-43ED-9B92-2C8768BC145E Q37623547-C610B6BE-FB1A-4D23-85CD-3A0F7C607C29

P2860

Bone morphogenetic protein signaling is impaired in an HFE knockout mouse model of hemochromatosis.

http://www.wikidata.org/entity/Q37376502

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 07 July 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Bone morphogenetic protein sig ...... ouse model of hemochromatosis.

@en

Bone morphogenetic protein sig ...... ouse model of hemochromatosis.

@nl

type

label

Bone morphogenetic protein sig ...... ouse model of hemochromatosis.

@en

Bone morphogenetic protein sig ...... ouse model of hemochromatosis.

@nl

prefLabel

Bone morphogenetic protein sig ...... ouse model of hemochromatosis.

@en

Bone morphogenetic protein sig ...... ouse model of hemochromatosis.

@nl

P1433

Q37376502-79E1002A-2D3F-46E9-B492-A99563BFB355

P1476

Q37376502-D7B421C3-05AA-4D72-B255-1382C4388D9F

P2093

Q37376502-61AEE6F5-6107-4AE5-AEC9-9247D7F429EE

Q37376502-69A15614-4C2A-4995-9EB6-820E2AF23964

Q37376502-6B4EF4FE-5B15-4C0B-9786-F83B3BA460B4

Q37376502-7C7A5EA6-7F62-488C-838D-4C72C2D2A6AF

Q37376502-A377FF2E-6E53-4237-BF68-6BD005F30A77

Q37376502-F92A8F90-9B7E-4CBD-9BBB-BD2BE65CF313

P2860

Q37376502-0289379F-1A6C-4CA3-9B2F-F24E2A89B7D3

Q37376502-03A908EF-0270-4AAB-90F9-315F797925FC

Q37376502-0493BC66-D712-42F5-9A1C-73B201AD0722

Q37376502-08D27AF2-BB20-41E1-B8AC-14B4BD249ED8

Q37376502-0CF5D471-92DC-4696-B6CB-E6F61BD2ACCE

Q37376502-11DAEE5A-12D6-4651-A580-4DE9AEB48D1B

Q37376502-14CBADEE-829C-46DF-A7EC-F9A26CA355C4

Q37376502-1885579F-51A6-438D-AA3E-F7A88592E9B5

Q37376502-30B944E9-695E-4F39-80E5-83EA8F258827

Q37376502-425CD51F-A0A8-465A-B4D1-F105BA59753E

P304

Q37376502-CBBB9DCC-33A9-49DE-BE5F-A865B0D46369

P31

Q37376502-C0862B6C-F651-477E-A94C-0C42D35AEFE7

P356

Q37376502-7E0C379B-96FF-4DE0-9EC4-2C36B3271415

P407

Q37376502-EA00595F-6655-4517-98F2-FFC6920025CF

P433

Q37376502-4A783B6E-4EB1-4720-8CA0-EB57D26FD6FB

P478

Q37376502-9D469CAE-B789-428D-B4AD-B1D7A1224226

P50

Q37376502-1326F633-47F4-4570-AC67-081D8791359D

Q37376502-FF4F6C19-DC13-42F0-98CF-DF38B63AB398

P577

Q37376502-17B4FAAA-A39B-424D-B519-6FCBE46D3E08

P5875

Q37376502-AA0408D8-E701-4AB9-BA82-7C4E7A9D4959

P698

Q37376502-675F6B92-7703-4FAD-BAD5-65219849AEA9

P921

Q37376502-21F33BE8-B9BE-4F71-BE1B-73EC578509C8

Q37376502-4BC4F730-C6F8-4BDD-9D49-8111D9EB102A

P932

Q37376502-A09CFB2E-6619-4D7F-8950-02C455A07416

P356

J.GASTRO.2009.06.057

P1433

Gastroenterology

P1476

Bone morphogenetic protein sig ...... ouse model of hemochromatosis.

@en

P2093

Antonello Pietrangelo

http://www.w3.org/2001/XMLSchema#string

Billy Andriopoulos

http://www.w3.org/2001/XMLSchema#string

Elena Corradini

http://www.w3.org/2001/XMLSchema#string

Herbert Y Lin

http://www.w3.org/2001/XMLSchema#string

Jodie L Babitt

http://www.w3.org/2001/XMLSchema#string

Paolo Ventura

http://www.w3.org/2001/XMLSchema#string

P2860

Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum

Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor

LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity

Hepcidin, a urinary antimicrobial peptide synthesized in the liver

The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding

Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis

Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

P304

1489-1497

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1053/J.GASTRO.2009.06.057

http://www.w3.org/2001/XMLSchema#string

P407

P433

4

http://www.w3.org/2001/XMLSchema#string

P478

137

http://www.w3.org/2001/XMLSchema#string

P50

Giuliana Montosi

P577

2009-07-07T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

26660784

http://www.w3.org/2001/XMLSchema#string

P698

19591830

http://www.w3.org/2001/XMLSchema#string

P921

P932

2757523

http://www.w3.org/2001/XMLSchema#string