The antifungal antibiotic, clotrimazole, inhibits chloride secretion by human intestinal T84 cells via blockade of distinct basolateral K+ conductances. Demonstration of efficacy in intact rabbit colon and in an in vivo mouse model of cholera.

The antifungal antibiotic, clotrimazole, inhibits chloride secretion by human intestinal T84 cells via blockade of distinct basolateral K+ conductances. Demonstration of efficacy in intact rabbit colon and in an in vivo mouse model of cholera.

Item

http://www.wikidata.org/entity/Q37376569

Q37376569

about

Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant Vibrio cholerae infection of Drosophila melanogaster mimics the human disease cholera.K+ Channel Inhibition Differentially Regulates Migration of Intestinal Epithelial Cells in Inflamed vs. Non-Inflamed Conditions in a PI3K/Akt-Mediated Manner Delineation of the clotrimazole/TRAM-34 binding site on the intermediate conductance calcium-activated potassium channel, IKCa1 Modulation of Ca2+-activated Cl- secretion by basolateral K+ channels in human normal and cystic fibrosis airway epithelia Disruption of the K+ channel beta-subunit KCNE3 reveals an important role in intestinal and tracheal Cl- transport The Epac1 signaling pathway regulates Cl- secretion via modulation of apical KCNN4c channels in diarrhea Inhibition of cAMP-activated intestinal chloride secretion by diclofenac: cellular mechanism and potential application in cholera Electrophysiological Studies into the Safety of the Anti-diarrheal Drug Clotrimazole during Oral Rehydration Therapy Mucosal potassium efflux mediated via Kcnn4 channels provides the driving force for electrogenic anion secretion in colon Active K+ secretion through multiple KCa-type channels and regulation by IKCa channels in rat proximal colon Characteristics of Kcnn4 channels in the apical membranes of an intestinal epithelial cell line Selective translocation of the Bordetella pertussis adenylate cyclase toxin across the basolateral membranes of polarized epithelial cells The in vitro and in vivo antitumor effects of clotrimazole on oral squamous cell carcinoma.Vibrio cholerae ensures function of host proteins required for virulence through consumption of luminal methionine sulfoxide.NS6180, a new K(Ca) 3.1 channel inhibitor prevents T-cell activation and inflammation in a rat model of inflammatory bowel disease.Phosphatidylinositol 3-phosphate indirectly activates KCa3.1 via 14 amino acids in the carboxy terminus of KCa3.1.Electrolyte transport in the mammalian colon: mechanisms and implications for disease.Molecular mechanisms of calcium-sensing receptor-mediated calcium signaling in the modulation of epithelial ion transport and bicarbonate secretion Berberine Reduces cAMP-Induced Chloride Secretion in T84 Human Colonic Carcinoma Cells through Inhibition of Basolateral KCNQ1 Channels.Lack of Restoration in Vivo by K-Channel Modulators of Jejunal Fluid Absorption after Heat Stable Escherichia coli Enterotoxin (STa) Challenge.Defective regulatory volume decrease in human cystic fibrosis tracheal cells because of altered regulation of intermediate conductance Ca2+-dependent potassium channels Therapeutic potential of KCa3.1 blockers: recent advances and promising trends.Cyclic AMP-induced K+ secretion occurs independently of Cl- secretion in rat distal colon Chloride channel diseases resulting from impaired transepithelial transport or vesicular function Structural Insights into the Atomistic Mechanisms of Action of Small Molecule Inhibitors Targeting the KCa3.1 Channel Pore.Secretory diarrhoea: mechanisms and emerging therapies.Ceramide activates JNK to inhibit a cAMP-gated K+ conductance and Cl- secretion in intestinal epithelia.Shikonin Inhibits Intestinal Calcium-Activated Chloride Channels and Prevents Rotaviral Diarrhea.Development of a QPatch automated electrophysiology assay for identifying KCa3.1 inhibitors and activators.Pathogen-induced secretory diarrhea and its prevention.The Cdc42 inhibitor secramine B prevents cAMP-induced K+ conductance in intestinal epithelial cells.Vibrio cholerae ACE stimulates Ca(2+)-dependent Cl(-)/HCO(3)(-) secretion in T84 cells in vitro.Blood-brain barrier KCa3.1 channels: evidence for a role in brain Na uptake and edema in ischemic stroke.Effects of the antifungal antibiotic clotrimazole on human cardiac repolarization potassium currents.Potassium currents regulating secretion from Brunner's glands in guinea pig duodenum.Zinc inhibits cAMP-stimulated Cl secretion via basolateral K-channel blockade in rat ileum.The distribution of intermediate-conductance, calcium-activated, potassium (IK) channels in epithelial cells.cDNA cloning and functional characterization of the mouse Ca2+-gated K+ channel, mIK1. Roles in regulatory volume decrease and erythroid differentiation.Importance of basolateral K+ conductance in maintaining Cl- secretion in murine nasal and colonic epithelia.

P2860

Q24675998-F7E2A817-4D6C-4903-B61C-DF9ADB857DB4 Q24817194-8498727C-A074-4FC6-B1D2-FA3EB3265666 Q27324841-4203546D-B740-478B-BD9C-9E21DA4B4D8A Q28203719-C89484C5-0AFE-4D89-813E-5B9937687103 Q28213143-2D8BD7FD-8620-4CD4-AB76-4AE37DA04A5A Q28269452-0B541F4D-D5F8-402C-86F3-337F66E85046 Q28385670-C89E4CC8-2598-402E-AB23-01F9CF0D1ABA Q28542764-54C7D099-CC2E-419B-ADDF-926BF211B11E Q28548532-E1242E9F-3BEB-4416-8BC6-9B562CAB4A7B Q28578786-B6468332-EF50-45C4-B4B5-0169577893E2 Q28582188-B9F0D5CF-946C-4F65-8BE7-7045EC791E7B Q28582738-19E4E796-3EC9-4589-A084-E64E6B197FA7 Q30432788-6BD22B3E-E7AA-4685-B233-20839A564E2E Q33707165-076F9376-F942-4FC7-92C0-A74CD57A42DD Q33807128-87517FB2-F118-4A17-AD15-BF55EACB9C6A Q34293957-C600939F-6579-4634-88BA-2ED1AD0C577F Q34298326-6E2B4F87-6E3E-4609-AE82-D2FF18AB6316 Q34482550-34DF1920-BC23-416D-A995-34EEDCFA5096 Q34683229-AFF0A210-EA9C-4EC1-B53A-819526345EFD Q35084796-FB2CC77B-08BF-47BF-A44B-82E0378F7E2A Q35099141-675BB086-AEC1-4D74-8D23-15144B025F33 Q35874293-5DA37758-A461-445A-ACFE-BE31AA6CC67C Q35944615-294C4E5C-D043-4F0C-853E-75F5CA90F5B9 Q36175717-CE62D0C1-4D05-4E2F-83F5-CEBD32A2BFCA Q36216300-B067C6BE-A838-44A0-B104-63B331948DE3 Q36261948-CF862448-3BB4-47CB-AFE1-4CEE0191E9A4 Q36673563-D87D4A3C-BB1C-42B7-A568-12514E1D7DA6 Q37061677-264BC772-E53C-4DF1-8FCD-FC33CB271F06 Q37194920-E903608B-A152-46E0-9338-4D8C0AE27235 Q37409003-8CA816AB-633F-4B9F-8917-326D1DB5186B Q38912737-135463F2-3B39-4E56-84CC-0CC82AF4B362 Q40283258-B4A75F98-D666-4684-805A-9DF764CB8142 Q40861457-1E27D5FE-8B14-4EF3-85C2-979870C5EEE0 Q42071157-524A3566-A4D0-4977-B995-A4EBD3504FE0 Q43054780-13F7EE63-2CEA-4F71-9881-6B83EA6D4922 Q44646901-6B7F1CEE-2C6E-4A95-B731-1C2EBFB9B630 Q45200716-334CD0BD-4713-49AF-B300-F35AD49F92F7 Q47648457-5FF86D48-5F36-494A-89B2-3DB7AB6171D6 Q47682481-0EF45A35-0D2A-4C4E-946D-11787D687B5D Q48567453-0F342237-247A-4A1E-A2DD-04D652B4E0D0

P2860

The antifungal antibiotic, clotrimazole, inhibits chloride secretion by human intestinal T84 cells via blockade of distinct basolateral K+ conductances. Demonstration of efficacy in intact rabbit colon and in an in vivo mouse model of cholera.

Item

http://www.wikidata.org/entity/Q37376569

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on December 1997

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs