about
Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchangeAPLF promotes the assembly and activity of non-homologous end joining protein complexesActivation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sitesStructural basis for recruitment of BRCA2 by PALB2The 3' to 5' Exoribonuclease DIS3: From Structure and Mechanisms to Biological Functions and Role in Human DiseaseCrystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2The Structural Basis for Substrate Recognition by Mammalian Polynucleotide Kinase 3′ PhosphataseFragment-based screening maps inhibitor interactions in the ATP-binding site of checkpoint kinase 2The BAH domain of Rsc2 is a histone H3 binding domainPhosphorylation-Dependent Assembly and Coordination of the DNA Damage Checkpoint Apparatus by Rad4TopBP1The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaksA first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain constructDestabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung diseasePreferential binding of fd gene 5 protein to tetraplex nucleic acid structures.PP2A/B55 and Fcp1 regulate Greatwall and Ensa dephosphorylation during mitotic exit.Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors.The XRCC1 phosphate-binding pocket binds poly (ADP-ribose) and is required for XRCC1 function.A Hypomorphic PALB2 Allele Gives Rise to an Unusual Form of FA-N Associated with Lymphoid Tumour DevelopmentIdentification and Characterization of a Novel Constitutional PIK3CA Mutation in a Child Lacking the Typical Segmental Overgrowth of "PIK3CA-Related Overgrowth Spectrum".Chromatin association of the SMC5/6 complex is dependent on binding of its NSE3 subunit to DNA.Cancer and the bromodomains of BAF180.TopBP1: A BRCT-scaffold protein functioning in multiple cellular pathways.Structural characterization of DNA and RNA sequences recognized by the gene 5 protein of bacteriophage fd.Structure of an archaeal PCNA1-PCNA2-FEN1 complex: elucidating PCNA subunit and client enzyme specificityPARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2)The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins.The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast.Structural basis for recruitment of BRCA2 by PALB2.Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2.Specialized interfaces of Smc5/6 control hinge stability and DNA association.Crystal structure of the proximal BAH domain of the polybromo protein.ATM Localization and Heterochromatin Repair Depend on Direct Interaction of the 53BP1-BRCT2 Domain with γH2AX.CCRK is a novel signalling hub exploitable in cancer immunotherapy.Regulation of DNA replication through Sld3-Dpb11 interaction is conserved from yeast to humans.DIS3 isoforms vary in their endoribonuclease activity and are differentially expressed within haematological cancers.BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligandsActivation segment exchange: a common mechanism of kinase autophosphorylation?The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivityDesign and discovery of 3-aryl-5-substituted-isoquinolin-1-ones as potent tankyrase inhibitorsAn Artemis polymorphic variant reduces Artemis activity and confers cellular radiosensitivity
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Antony W Oliver
@es
Antony W Oliver
@nl
Antony W Oliver
@sl
Antony W. Oliver
@en
type
label
Antony W Oliver
@es
Antony W Oliver
@nl
Antony W Oliver
@sl
Antony W. Oliver
@en
altLabel
Tony Oliver
@en
prefLabel
Antony W Oliver
@es
Antony W Oliver
@nl
Antony W Oliver
@sl
Antony W. Oliver
@en
P106
P1153
7201901734
P21
P31
P496
0000-0002-2912-8273