Platelet microbicidal proteins and neutrophil defensin disrupt the Staphylococcus aureus cytoplasmic membrane by distinct mechanisms of action.
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Antibacterial action of structurally diverse cationic peptides on gram-positive bacteriaTelavancin, a multifunctional lipoglycopeptide, disrupts both cell wall synthesis and cell membrane integrity in methicillin-resistant Staphylococcus aureusThe antimicrobial peptide histatin-5 causes a spatially restricted disruption on the Candida albicans surface, allowing rapid entry of the peptide into the cytoplasmStructure and mechanism of action of an indolicidin peptide derivative with improved activity against gram-positive bacteriaAntimicrobial Activity of Cationic Antimicrobial Peptides against Gram-Positives: Current Progress Made in Understanding the Mode of Action and the Response of BacteriaContext mediates antimicrobial efficacy of kinocidin congener peptide RP-1Thrombocidins, microbicidal proteins from human blood platelets, are C-terminal deletion products of CXC chemokines.Emergence of daptomycin resistance in daptomycin-naïve rabbits with methicillin-resistant Staphylococcus aureus prosthetic joint infection is associated with resistance to host defense cationic peptides and mprF polymorphisms.Antifungal activity of synthetic peptide derived from halocidin, antimicrobial peptide from the tunicate, Halocynthia aurantium.Modular determinants of antimicrobial activity in platelet factor-4 family kinocidins.Platelet mitochondrial membrane depolarization reflects disease severity in patients with sepsis and correlates with clinical outcomeMembrane permeabilization by thrombin-induced platelet microbicidal protein 1 is modulated by transmembrane voltage polarity and magnitudeReduced susceptibility of Staphylococcus aureus to vancomycin and platelet microbicidal protein correlates with defective autolysis and loss of accessory gene regulator (agr) functionSepsis prediction in critically ill patients by platelet activation markers on ICU admission: a prospective pilot study.Functional interrelationships between cell membrane and cell wall in antimicrobial peptide-mediated killing of Staphylococcus aureus.In vitro antibacterial activities of platelet microbicidal protein and neutrophil defensin against Staphylococcus aureus are influenced by antibiotics differing in mechanism of action.Plasmid-mediated resistance to thrombin-induced platelet microbicidal protein in staphylococci: role of the qacA locus.Defensins impair phagocytic killing by neutrophils in biomaterial-related infection.In vitro resistance of Staphylococcus aureus to thrombin-induced platelet microbicidal protein is associated with alterations in cytoplasmic membrane fluidityDiversity in antistaphylococcal mechanisms among membrane-targeting antimicrobial peptidesCell wall thickening is not a universal accompaniment of the daptomycin nonsusceptibility phenotype in Staphylococcus aureus: evidence for multiple resistance mechanismsNovel anti-bacterial activities of β-defensin 1 in human platelets: suppression of pathogen growth and signaling of neutrophil extracellular trap formation.DltABCD- and MprF-mediated cell envelope modifications of Staphylococcus aureus confer resistance to platelet microbicidal proteins and contribute to virulence in a rabbit endocarditis model.Transposon disruption of the complex I NADH oxidoreductase gene (snoD) in Staphylococcus aureus is associated with reduced susceptibility to the microbicidal activity of thrombin-induced platelet microbicidal protein 1.Platelet factor 4 and Duffy antigen required for platelet killing of Plasmodium falciparum.Heterogeneity of mprF sequences in methicillin-resistant Staphylococcus aureus clinical isolates: role in cross-resistance between daptomycin and host defense antimicrobial peptides.Low-level resistance of Staphylococcus aureus to thrombin-induced platelet microbicidal protein 1 in vitro associated with qacA gene carriage is independent of multidrug efflux pump activityA novel conditional platelet depletion mouse model reveals the importance of platelets in protection against Staphylococcus aureus bacteremia.A synthetic congener modeled on a microbicidal domain of thrombin- induced platelet microbicidal protein 1 recapitulates staphylocidal mechanisms of the native moleculeCorrelation of daptomycin bactericidal activity and membrane depolarization in Staphylococcus aureus.Phenotypic and genotypic characterization of daptomycin-resistant methicillin-resistant Staphylococcus aureus strains: relative roles of mprF and dlt operonsPro-moieties of antimicrobial peptide prodrugs.The Staphylococcus aureus two-component regulatory system, GraRS, senses and confers resistance to selected cationic antimicrobial peptides.Antimicrobial characterization of human beta-defensin 3 derivatives.Frequency and Distribution of Single-Nucleotide Polymorphisms within mprF in Methicillin-Resistant Staphylococcus aureus Clinical Isolates and Their Role in Cross-Resistance to Daptomycin and Host Defense Antimicrobial PeptidesAllogeneic platelet leucocyte-gel to treat occipital decubitus ulcer in a neonate: a case report.Reduced susceptibility to host-defense cationic peptides and daptomycin coemerge in methicillin-resistant Staphylococcus aureus from daptomycin-naive bacteremic patients.Failures in clinical treatment of Staphylococcus aureus Infection with daptomycin are associated with alterations in surface charge, membrane phospholipid asymmetry, and drug binding.The GraS Sensor in Staphylococcus aureus Mediates Resistance to Host Defense Peptides Differing in Mechanisms of Action.Mechanisms of daptomycin resistance in Staphylococcus aureus: role of the cell membrane and cell wall.
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Platelet microbicidal proteins and neutrophil defensin disrupt the Staphylococcus aureus cytoplasmic membrane by distinct mechanisms of action.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 1998
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Platelet microbicidal proteins ...... distinct mechanisms of action.
@en
Platelet microbicidal proteins ...... distinct mechanisms of action.
@nl
type
label
Platelet microbicidal proteins ...... distinct mechanisms of action.
@en
Platelet microbicidal proteins ...... distinct mechanisms of action.
@nl
prefLabel
Platelet microbicidal proteins ...... distinct mechanisms of action.
@en
Platelet microbicidal proteins ...... distinct mechanisms of action.
@nl
P2093
P2860
P356
P1476
Platelet microbicidal proteins ...... distinct mechanisms of action.
@en
P2093
P2860
P304
P356
10.1172/JCI562
P407
P577
1998-01-01T00:00:00Z