Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma.
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Physiological and pathological implications of 5-hydroxymethylcytosine in diseasesHypoxia, Epithelial-Mesenchymal Transition, and TET-Mediated Epigenetic ChangesThe TET2 interactors and their links to hematological malignanciesClinical impact of recurrently mutated genes on lymphoma diagnostics: state-of-the-art and beyondAge-related clonal hematopoiesis associated with adverse outcomesTet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells.Diffuse large B-cell lymphoma with combined TP53 mutation and MIR34A methylation: Another "double hit" lymphoma with very poor outcome?Global methylation and promoter-specific methylation of the P16, SOCS-1, E-cadherin, P73 and SHP-1 genes and their expression in patients with multiple myeloma during active disease and remissionTET proteins and the control of cytosine demethylation in cancer.DUSP4 deficiency caused by promoter hypermethylation drives JNK signaling and tumor cell survival in diffuse large B cell lymphomaLoss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis.Overexpression of DNA methyltransferase 1 as a negative independent prognostic factor in primary gastrointestinal diffuse large B-cell lymphoma treated with CHOP-like regimen and rituximab.Clinical significance of DNA methylation mRNA levels of TET family members in colorectal cancer.TET2 Mutations Affect Non-CpG Island DNA Methylation at Enhancers and Transcription Factor-Binding Sites in Chronic Myelomonocytic Leukemia.TET1 is a tumor suppressor of hematopoietic malignancyIdentification of cell-type-specific mutations in nodal T-cell lymphomas.Whole-exome sequencing and genome-wide methylation analyses identify novel disease associated mutations and methylation patterns in idiopathic hypereosinophilic syndrome.The Impact of DNA Methylation in Hematopoietic Malignancies.Aberrant methylation of cell-free circulating DNA in plasma predicts poor outcome in diffuse large B cell lymphomaCharacterization of TET and IDH gene expression in chronic lymphocytic leukemia: comparison with normal B cells and prognostic significanceIntegrated analysis of genome‑wide gene expression and DNA methylation microarray of diffuse large B‑cell lymphoma with TET mutations.TET2 mutations in B cells of patients affected by angioimmunoblastic T-cell lymphoma.Germline mutations predisposing to diffuse large B-cell lymphoma.Dysregulation of TET2 in hematologic malignancies.Epigenetic dysregulation of hematopoietic stem cells and preleukemic state.Validation of DNA methylation profiling in formalin-fixed paraffin-embedded samples using the Infinium HumanMethylation450 Microarray.A novel del(8)(q23.2q24.11) contributing to disease progression in a case of JAK2/TET2 double mutated chronic myelomonocytic leukemia.Reduced TET2 function leads to T-cell lymphoma with follicular helper T-cell-like features in mice.Epigenetic approaches for chemosensitization of refractory diffuse large B-cell lymphomas.Epigenetic changes in myelofibrosis: Distinct methylation changes in the myeloid compartments and in cases with ASXL1 mutationsTET2 overexpression in chronic lymphocytic leukemia is unrelated to the presence of TET2 variations.Synchronous Occurrence of Mycosis Fungoides, Diffuse Large B Cell Lymphoma and Acute Myeloid Leukemia.The deregulated promoter methylation of the Polo-like kinases as a potential biomarker in hematological malignancies.Overlap at the molecular and immunohistochemical levels between angioimmunoblastic T-cell lymphoma and a subgroup of peripheral T-cell lymphomas without specific morphological features.
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Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 05 July 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Genome-wide profiling identifi ...... diffuse large B-cell lymphoma.
@en
Genome-wide profiling identifi ...... diffuse large B-cell lymphoma.
@nl
type
label
Genome-wide profiling identifi ...... diffuse large B-cell lymphoma.
@en
Genome-wide profiling identifi ...... diffuse large B-cell lymphoma.
@nl
prefLabel
Genome-wide profiling identifi ...... diffuse large B-cell lymphoma.
@en
Genome-wide profiling identifi ...... diffuse large B-cell lymphoma.
@nl
P2093
P2860
P50
P1433
P1476
Genome-wide profiling identifi ...... diffuse large B-cell lymphoma.
@en
P2093
Anders B Nielsen
Anja Pedersen
Christoffer Hother
Elisabeth Ralfkiaer
Fazila Asmar
Jesper Christensen
Peter Brown
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P304
P356
10.3324/HAEMATOL.2013.088740
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2013-07-05T00:00:00Z