about
Long-term engagement of CD6 and ALCAM is essential for T-cell proliferation induced by dendritic cellsRac activation by lysophosphatidic acid LPA1 receptors through the guanine nucleotide exchange factor Tiam1Cytoskeletal restraints regulate homotypic ALCAM-mediated adhesion through PKCalpha independently of Rho-like GTPasesTRPM7, a novel regulator of actomyosin contractility and cell adhesion.The dishevelled protein is modified by wingless signaling in DrosophilaMassive autophosphorylation of the Ser/Thr-rich domain controls protein kinase activity of TRPM6 and TRPM7.Regulation of MYCN expression in human neuroblastoma cells.Revertant somatic mosaicism by mitotic recombination in dyskeratosis congenita.Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.Influence of genetic variants in TPMT and COMT associated with cisplatin induced hearing loss in patients with cancer: two new cohorts and a meta-analysis reveal significant heterogeneity between cohorts.Organization of the integrin LFA-1 in nanoclusters regulates its activity.Targeted Deletion of Btg1 and Btg2 Results in Homeotic Transformation of the Axial SkeletonTRPM7 regulates myosin IIA filament stability and protein localization by heavy chain phosphorylation.Microdomains of the C-type lectin DC-SIGN are portals for virus entry into dendritic cellsMyosin II and mechanotransduction: a balancing act.TRPM7 triggers Ca2+ sparks and invadosome formation in neuroblastoma cellsHuman and murine model cell lines for dendritic cell biology evaluated.The alpha-kinase family: an exceptional branch on the protein kinase tree.Mechanoregulation of cytoskeletal dynamics by TRP channels.B-lineage transcription factors and cooperating gene lesions required for leukemia development.TRPM7 is required for breast tumor cell metastasis.BTG1 regulates glucocorticoid receptor autoinduction in acute lymphoblastic leukemia.Integrated use of minimal residual disease classification and IKZF1 alteration status accurately predicts 79% of relapses in pediatric acute lymphoblastic leukemia.The alpha-kinases TRPM6 and TRPM7, but not eEF-2 kinase, phosphorylate the assembly domain of myosin IIA, IIB and IIC.Activation of TRPM7 channels by phospholipase C-coupled receptor agonists.Oncogene activation and oncogene cooperation in MMTV-induced mouse mammary cancer.Rac regulates phosphorylation of the myosin-II heavy chain, actinomyosin disassembly and cell spreading.Biological activity of soluble wingless protein in cultured Drosophila imaginal disc cells.Geometry sensing by dendritic cells dictates spatial organization and PGE(2)-induced dissolution of podosomes.Targeting of Tiam1 to the plasma membrane requires the cooperative function of the N-terminal pleckstrin homology domain and an adjacent protein interaction domain.Diffusion-driven device for a high-resolution dose-response profiling of combination chemotherapy.PGE2-mediated podosome loss in dendritic cells is dependent on actomyosin contraction downstream of the RhoA-Rho-kinase axis.DNA copy number alterations mark disease progression in paediatric chronic myeloid leukaemia.TLR4-mediated podosome loss discriminates gram-negative from gram-positive bacteria in their capacity to induce dendritic cell migration and maturation.A First Step toward Personalized Medicine in Osteosarcoma: Pharmacogenetics as Predictive Marker of Outcome after Chemotherapy-Based Treatment.Expression of Tiam-1 in the developing brain suggests a role for the Tiam-1-Rac signaling pathway in cell migration and neurite outgrowth.Distinct kinetic and mechanical properties govern ALCAM-mediated interactions as shown by single-molecule force spectroscopy.High-resolution genomic profiling of childhood ALL reveals novel recurrent genetic lesions affecting pathways involved in lymphocyte differentiation and cell cycle progression.Kinase activity profiling reveals active signal transduction pathways in pediatric acute lymphoblastic leukemia: a new approach for target discovery.Vascular Smooth Muscle Cell Differentiation to an Osteogenic Phenotype Involves TRPM7 Modulation by Magnesium
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Frank N van Leeuwen
@ast
Frank N van Leeuwen
@en
Frank N van Leeuwen
@es
Frank N van Leeuwen
@nl
Frank N van Leeuwen
@sl
type
label
Frank N van Leeuwen
@ast
Frank N van Leeuwen
@en
Frank N van Leeuwen
@es
Frank N van Leeuwen
@nl
Frank N van Leeuwen
@sl
prefLabel
Frank N van Leeuwen
@ast
Frank N van Leeuwen
@en
Frank N van Leeuwen
@es
Frank N van Leeuwen
@nl
Frank N van Leeuwen
@sl
P1053
F-3209-2010
P106
P21
P31
P3829
P496
0000-0003-1107-6513