Rational design of sulfonated A3 adenosine receptor-selective nucleosides as pharmacological tools to study chronic neuropathic pain.
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Peripheral Adenosine A3 Receptor Activation Causes Regulated Hypothermia in Mice That Is Dependent on Central Histamine H1 Receptors.Purine (N)-Methanocarba Nucleoside Derivatives Lacking an Exocyclic Amine as Selective A3 Adenosine Receptor Agonists.Synthesis and evaluation of N⁶-substituted apioadenosines as potential adenosine A₃ receptor modulators.Probing biased/partial agonism at the G protein-coupled A(2B) adenosine receptor.Extended N(6) substitution of rigid C2-arylethynyl nucleosides for exploring the role of extracellular loops in ligand recognition at the A3 adenosine receptor.In vivo phenotypic screening for treating chronic neuropathic pain: modification of C2-arylethynyl group of conformationally constrained A3 adenosine receptor agonists.John Daly Lecture: Structure-guided Drug Design for Adenosine and P2Y ReceptorsRigidified A3 Adenosine Receptor Agonists: 1-Deazaadenine Modification Maintains High in Vivo EfficacyMedicinal chemistry of adenosine, P2Y and P2X receptors.Structure-Based Design, Synthesis by Click Chemistry and in Vivo Activity of Highly Selective A3 Adenosine Receptor Agonists.Identification of A3 adenosine receptor agonists as novel non-narcotic analgesics.Structure-based and fragment-based GPCR drug discovery.Expanding the horizons of G protein-coupled receptor structure-based ligand discovery and optimization using homology models.Hypothermia in mouse is caused by adenosine A1 and A3 receptor agonists and AMP via three distinct mechanisms.A3 Adenosine Receptors as Modulators of Inflammation: From Medicinal Chemistry to Therapy.Species differences and mechanism of action of A3 adenosine receptor allosteric modulators.Breakthrough in GPCR Crystallography and Its Impact on Computer-Aided Drug Design.Bitopic fluorescent antagonists of the A2A adenosine receptor based on pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine functionalized congeners.Exploring the Role of N6-Substituents in Potent Dual Acting 5'-C-Ethyltetrazolyladenosine Derivatives: Synthesis, Binding, Functional Assays, and Antinociceptive Effects in Mice ∇.BODIPY(®) FL histamine as a new modality for quantitative detection of histamine receptor upregulation upon IgE sensitization in murine bone marrow-derived mast cells.Repurposing of a Nucleoside Scaffold from Adenosine Receptor Agonists to Opioid Receptor Antagonists
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P2860
Rational design of sulfonated A3 adenosine receptor-selective nucleosides as pharmacological tools to study chronic neuropathic pain.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 03 July 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Rational design of sulfonated ...... tudy chronic neuropathic pain.
@en
Rational design of sulfonated ...... tudy chronic neuropathic pain.
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type
label
Rational design of sulfonated ...... tudy chronic neuropathic pain.
@en
Rational design of sulfonated ...... tudy chronic neuropathic pain.
@nl
prefLabel
Rational design of sulfonated ...... tudy chronic neuropathic pain.
@en
Rational design of sulfonated ...... tudy chronic neuropathic pain.
@nl
P2093
P2860
P50
P921
P356
P1476
Rational design of sulfonated ...... tudy chronic neuropathic pain.
@en
P2093
Amanda Finley
Daniela Salvemini
Elizabeth T Gizewski
John A Auchampach
Steven M Moss
P2860
P304
P356
10.1021/JM4007966
P407
P577
2013-07-03T00:00:00Z