about
Molecular modelling of the emergence of azole resistance in Mycosphaerella graminicolaDiscovery of a novel dual fungal CYP51/human 5-lipoxygenase inhibitor: implications for anti-fungal therapyConservation and cloning of CYP51: a sterol 14 alpha-demethylase from Mycobacterium smegmatis.A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B.Azole binding properties of Candida albicans sterol 14-alpha demethylase (CaCYP51).Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.Azole resistance by loss of function of the sterol Δ⁵,⁶-desaturase gene (ERG3) in Candida albicans does not necessarily decrease virulenceResistance to antifungals that target CYP51.The clinical candidate VT-1161 is a highly potent inhibitor of Candida albicans CYP51 but fails to bind the human enzyme.S279 point mutations in Candida albicans Sterol 14-α demethylase (CYP51) reduce in vitro inhibition by fluconazole.Molecular mechanisms of drug resistance in clinical Candida species isolated from Tunisian hospitalsCharacterization of the sterol 14α-demethylases of Fusarium graminearum identifies a novel genus-specific CYP51 function.Heterologous expression of mutated eburicol 14alpha-demethylase (CYP51) proteins of Mycosphaerella graminicola to assess effects on azole fungicide sensitivity and intrinsic protein function.Expression, purification and use of the soluble domain of Lactobacillus paracasei beta-fructosidase to optimise production of bioethanol from grass fructans.Differential azole antifungal efficacies contrasted using a Saccharomyces cerevisiae strain humanized for sterol 14 alpha-demethylase at the homologous locus.Expression of bacterial levanase in yeast enables simultaneous saccharification and fermentation of grass juice to bioethanolThe negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus
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description
hulumtuese
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Josie E Parker
@nl
Josie E Parker
@sl
Josie E. Parker
@en
Josie E. Parker
@es
type
label
Josie E Parker
@nl
Josie E Parker
@sl
Josie E. Parker
@en
Josie E. Parker
@es
prefLabel
Josie E Parker
@nl
Josie E Parker
@sl
Josie E. Parker
@en
Josie E. Parker
@es
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P1153
26022008700
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0000-0002-3855-4194