Off-Target V(D)J Recombination Drives Lymphomagenesis and Is Escalated by Loss of the Rag2 C Terminus.
about
RAG1 targeting in the genome is dominated by chromatin interactions mediated by the non-core regions of RAG1 and RAG2.The miR-15 family reinforces the transition from proliferation to differentiation in pre-B cells.Cell cycle RNA regulons coordinating early lymphocyte development.Illegitimate RAG-mediated recombination events are involved in IKZF1 Δ3-6 deletion in BCR-ABL1 lymphoblastic leukaemia.RAG Recombinase as a Selective Pressure for Genome EvolutionThe IGH locus relocalizes to a "recombination compartment" in the perinucleolar region of differentiating B-lymphocytes.RAG1/2 induces genomic insertions by mobilizing DNA into RAG1/2-independent breaksThe Conserved ATM Kinase RAG2-S365 Phosphorylation Site Limits Cleavage Events in Individual Cells Independent of Any Repair Defect.
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Off-Target V(D)J Recombination Drives Lymphomagenesis and Is Escalated by Loss of the Rag2 C Terminus.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 09 September 2015
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Off-Target V
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Off-Target V(D)J Recombination ...... y Loss of the Rag2 C Terminus.
@en
type
label
Off-Target V
@nl
Off-Target V(D)J Recombination ...... y Loss of the Rag2 C Terminus.
@en
prefLabel
Off-Target V
@nl
Off-Target V(D)J Recombination ...... y Loss of the Rag2 C Terminus.
@en
P2093
P2860
P1433
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Off-Target V(D)J Recombination ...... y Loss of the Rag2 C Terminus.
@en
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Cory R Lindsay
David B Roth
Martina Mijušković
Olga Shestova
Susanna M Lewis
Vered Gigi
Yi-Fan Chou
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P304
P356
10.1016/J.CELREP.2015.08.034
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2015-09-09T00:00:00Z