A two-amino acid insertion in the Cys146- Cys167 loop of the alphaIIb subunit is associated with a variant of Glanzmann thrombasthenia. Critical role of Asp163 in ligand binding.

A two-amino acid insertion in the Cys146- Cys167 loop of the alphaIIb subunit is associated with a variant of Glanzmann thrombasthenia. Critical role of Asp163 in ligand binding.

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http://www.wikidata.org/entity/Q37387501
Glanzmann thrombasthenia: state of the art and future directions.Integrin structure: new twists and turns in dynamic cell adhesion.Three novel beta-propeller mutations causing Glanzmann thrombasthenia result in production of normally stable pro-alphaIIb, but variably impaired progression of pro-alphaIIbbeta3 from endoplasmic reticulum to GolgiUnderstanding the genetic basis of Glanzmann thrombasthenia: implications for treatment.Multiple discontinuous ligand-mimetic antibody binding sites define a ligand binding pocket in integrin alpha(IIb)beta(3).High affinity ligand binding by integrins does not involve head separation.Evidence that integrin alpha IIb beta 3-dependent interaction of mast cells with fibrinogen exacerbates chronic inflammation.Amino acid residues in the alpha IIb subunit that are critical for ligand binding to integrin alpha IIbbeta 3 are clustered in the beta-propeller model.Bleeding tendency and impaired platelet function in a patient carrying a heterozygous mutation in the thromboxane A2 receptor.Molecular Basis of Ligand Recognition by Integrin α5β1Molecular Basis of Ligand Recognition by Integrin α5β1
P2860

A two-amino acid insertion in the Cys146- Cys167 loop of the alphaIIb subunit is associated with a variant of Glanzmann thrombasthenia. Critical role of Asp163 in ligand binding.

Item
http://www.wikidata.org/entity/Q37387501
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on September 1998
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
A two-amino acid insertion in ...... e of Asp163 in ligand binding.
@en
A two-amino acid insertion in ...... e of Asp163 in ligand binding.
@nl
type
label
A two-amino acid insertion in ...... e of Asp163 in ligand binding.
@en
A two-amino acid insertion in ...... e of Asp163 in ligand binding.
@nl
prefLabel
A two-amino acid insertion in ...... e of Asp163 in ligand binding.
@en
A two-amino acid insertion in ...... e of Asp163 in ligand binding.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P921
P932
P356
P1433
P1476
A two-amino acid insertion in ...... e of Asp163 in ligand binding.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P921
P932