Nuclear scaffold/matrix attached region modules linked to a transcription unit are sufficient for replication and maintenance of a mammalian episome.
about
pEPito: a significantly improved non-viral episomal expression vector for mammalian cellsStable S/MAR-based episomal vectors are regulated at the chromatin level12th annual congress of the European Society of Gene Therapy.Cytomegalovirus replicon-based regulation of gene expression in vitro and in vivo.Establishment and mitotic stability of an extra-chromosomal mammalian replicon.Intranuclear trafficking of episomal DNA is transcription-dependent.Genetic modification of cancer cells using non-viral, episomal S/MAR vectors for in vivo tumour modelling.Safe engineering of CAR T cells for adoptive cell therapy of cancer using long-term episomal gene transfer.Genetically modified pigs produced with a nonviral episomal vector.An S/MAR-based L1 retrotransposition cassette mediates sustained levels of insertional mutagenesis without suffering from epigenetic silencing of DNA methylationGeneration of a tumor- and tissue-specific episomal non-viral vector system.Persistent episomal transgene expression in liver following delivery of a scaffold/matrix attachment region containing non-viral vector.Development and validation of non-integrative, self-limited, and replicating minicircles for safe reporter gene imaging of cell-based therapiesExtended duration of transgene expression from pegylated POD nanoparticles enables attenuation of photoreceptor degeneration.BRCA1 silencing is associated with failure of DNA repairing in retinal neurocytesKaposi's sarcoma-associated herpesvirus ori-Lyt-dependent DNA replication: dual role of replication and transcription activator.The chromatin scaffold protein SAFB1 localizes SUMO-1 to the promoters of ribosomal protein genes to facilitate transcription initiation and splicing.Vector design for expression of O6-methylguanine-DNA methyltransferase in hematopoietic cells.Kaposi's sarcoma-associated herpesvirus ori-Lyt-dependent DNA replication: involvement of host cellular factorsThrombospondin-1 might be a therapeutic target to suppress RB cells by regulating the DNA double-strand breaks repair.Enhanced and prolonged baculovirus-mediated expression by incorporating recombinase system and in cis elements: a comparative studyA Z-DNA sequence reduces slipped-strand structure formation in the myotonic dystrophy type 2 (CCTG) x (CAGG) repeatGenetic modification of dividing cells using episomally maintained S/MAR DNA vectors.Nonviral ocular gene therapy: assessment and future directions.Nanoparticles for retinal gene therapy.Non-viral episomal modification of cells using S/MAR elements.Nucleic-acid based gene therapeutics: delivery challenges and modular design of nonviral gene carriers and expression cassettes to overcome intracellular barriers for sustained targeted expression.Epigenetic landscape for initiation of DNA replication.Selective matrix attachment regions in T helper cell subsets support loop conformation in the Ifng gene.Gene transfer into human hematopoietic progenitor cells with an episomal vector carrying an S/MAR element.S/MAR sequence confers long-term mitotic stability on non-integrating lentiviral vector episomes without selection.High-level transgene expression by homologous recombination-mediated gene transfer.Spatiotemporal modeling and analysis of transient gene delivery.Long-term suppression of hepatitis B virus replication by short hairpin RNA expression using the scaffold/matrix attachment region-based replicating vector system pEPI-1.Episomal high copy number maintenance of hairpin-capped DNA bearing a replication initiation region in human cells.Prohibitin physically interacts with MCM proteins and inhibits mammalian DNA replication.A stable proteinaceous structure in the territory of inactive X chromosomes.Non-integrating lentiviral vectors based on the minimal S/MAR sequence retain transgene expression in dividing cells.A Novel Adenoviral Hybrid-vector System Carrying a Plasmid Replicon for Safe and Efficient Cell and Gene Therapeutic Applications.The β-globin Replicator greatly enhances the potential of S/MAR based episomal vectors for gene transfer into human haematopoietic progenitor cells.
P2860
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P2860
Nuclear scaffold/matrix attached region modules linked to a transcription unit are sufficient for replication and maintenance of a mammalian episome.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 22 July 2004
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Nuclear scaffold/matrix attach ...... enance of a mammalian episome.
@en
Nuclear scaffold/matrix attach ...... enance of a mammalian episome.
@nl
type
label
Nuclear scaffold/matrix attach ...... enance of a mammalian episome.
@en
Nuclear scaffold/matrix attach ...... enance of a mammalian episome.
@nl
prefLabel
Nuclear scaffold/matrix attach ...... enance of a mammalian episome.
@en
Nuclear scaffold/matrix attach ...... enance of a mammalian episome.
@nl
P2093
P2860
P356
P1476
Nuclear scaffold/matrix attach ...... enance of a mammalian episome.
@en
P2093
Andreas C W Jenke
Armin Baiker
Frank Herrmann
Frank O Fackelmayer
Hans J Lipps
Isa M Stehle
Jürgen Bode
Tobias Eisenberger
P2860
P304
11322-11327
P356
10.1073/PNAS.0401355101
P407
P577
2004-07-22T00:00:00Z