Revving the Throttle on an oncogene: CDK8 takes the driver seat. - Wikidata - awgldk - TriplyDB

Revving the Throttle on an oncogene: CDK8 takes the driver seat.

Revving the Throttle on an oncogene: CDK8 takes the driver seat.

http://www.wikidata.org/entity/Q37389726

about

Targeting cyclin-dependent kinases in human cancers: from small molecules to Peptide inhibitors Structure-kinetic relationship study of CDK8/CycC specific compounds MicroRNA-101 is a potential prognostic indicator of laryngeal squamous cell carcinoma and modulates CDK8 Personalized oncology through integrative high-throughput sequencing: a pilot study.Multilayer-omics analysis of renal cell carcinoma, including the whole exome, methylome and transcriptome.CDK8: a positive regulator of transcription Retroviral cyclin controls cyclin-dependent kinase 8-mediated transcription elongation and reinitiation.CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator Multiparametric cell-based assay for the evaluation of transcription inhibition by high-content imaging.Effects of cyclin-dependent kinase 8 specific siRNA on the proliferation and apoptosis of colon cancer cells.Outsmarting a mastermind.All-atomic molecular dynamic studies of human CDK8: insight into the A-loop, point mutations and binding with its partner CycC.Aspergillus fumigatus Afssn3-Afssn8 Pair Reverse regulates Azole Resistance by Conferring Extracellular Polysaccharide, Sphingolipid Pathway Intermediates and Efflux Pumps to Biofilm.An integrated suite of modeling tools that empower scientists in structure- and property-based drug design.

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Revving the Throttle on an oncogene: CDK8 takes the driver seat.

http://www.wikidata.org/entity/Q37389726

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

@pt

bilimsel makale

@tr

scientific article published on 06 October 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Revving the Throttle on an oncogene: CDK8 takes the driver seat.

@en

Revving the Throttle on an oncogene: CDK8 takes the driver seat.

@nl

type

label

Revving the Throttle on an oncogene: CDK8 takes the driver seat.

@en

Revving the Throttle on an oncogene: CDK8 takes the driver seat.

@nl

prefLabel

Revving the Throttle on an oncogene: CDK8 takes the driver seat.

@en

Revving the Throttle on an oncogene: CDK8 takes the driver seat.

@nl

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0008-5472.CAN-09-1704

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Cancer Research

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Revving the Throttle on an oncogene: CDK8 takes the driver seat.

@en

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Ron Firestein

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William C Hahn

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P2860

Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation

The human CDK8 subcomplex is a histone kinase that requires Med12 for activity and can function independently of mediator

p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction

PCAF acetylates {beta}-catenin and improves its stability

PTEN-deficient intestinal stem cells initiate intestinal polyposis.

CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity

Acetylation of beta-catenin by p300 regulates beta-catenin-Tcf4 interaction

The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth

Curbing the nuclear activities of beta-catenin. Control over Wnt target gene expression

E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8

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7899-7901

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scholarly article

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10.1158/0008-5472.CAN-09-1704

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20

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69

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2009-10-06T00:00:00Z

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19808961

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2763033

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