Tumor-derived TGF-beta mediates conversion of CD4+Foxp3+ regulatory T cells in a murine model of pancreas cancer. - Wikidata - awgldk - TriplyDB

Tumor-derived TGF-beta mediates conversion of CD4+Foxp3+ regulatory T cells in a murine model of pancreas cancer.

Tumor-derived TGF-beta mediates conversion of CD4+Foxp3+ regulatory T cells in a murine model of pancreas cancer.

http://www.wikidata.org/entity/Q37389994

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Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma Genetics and biology of pancreatic ductal adenocarcinoma Interaction between natural killer cells and regulatory T cells: perspectives for immunotherapy Crosstalk of carcinoembryonic antigen and transforming growth factor-β via their receptors: comparing human and canine cancer Cancer-FOXP3 directly activated CCL5 to recruit FOXP3+Treg cells in pancreatic ductal adenocarcinoma.PGE(2) contributes to TGF-beta induced T regulatory cell function in human non-small cell lung cancer.Rebalancing immune specificity and function in cancer by T-cell receptor gene therapy.Optimal population of FoxP3+ T cells in tumors requires an antigen priming-dependent trafficking receptor switch Losartan slows pancreatic tumor progression and extends survival of SPARC-null mice by abrogating aberrant TGFβ activation.Tumor microenvironment macrophage inhibitory factor directs the accumulation of interleukin-17-producing tumor-infiltrating lymphocytes and predicts favorable survival in nasopharyngeal carcinoma patients.Thymus-derived rather than tumor-induced regulatory T cells predominate in brain tumors T cell receptor transgenic lymphocytes infiltrating murine tumors are not induced to express foxp3.Process of hepatic metastasis from pancreatic cancer: biology with clinical significance.Challenges and future perspectives of T cell immunotherapy in cancer Pancreatic ductal adenocarcinoma: a review of immunologic aspects.The role of inflammatory cells in fostering pancreatic cancer cell growth and invasion Naringenin prevents TGF-β1 secretion from breast cancer and suppresses pulmonary metastasis by inhibiting PKC activation.Induction of Th17 cells in the tumor microenvironment improves survival in a murine model of pancreatic cancer.Natural Killer Dendritic Cells Enhance Immune Responses Elicited by α -Galactosylceramide-Stimulated Natural Killer T Cells.Immunotherapy: shifting the balance of cell-mediated immunity and suppression in human prostate cancer.Shifting the equilibrium in cancer immunoediting: from tumor tolerance to eradication.How numbers, nature, and immune status of foxp3(+) regulatory T-cells shape the early immunological events in tumor development Cancer cell-derived IL-1α induces CCL22 and the recruitment of regulatory T cells.The polarization of immune cells in the tumour environment by TGFbeta.Role of immune cells in pancreatic cancer from bench to clinical application: An updated review Autoimmunity as a double agent in tumor killing and cancer promotion.Lymphatics: at the interface of immunity, tolerance, and tumor metastasis.The immune network in pancreatic cancer development and progression.Immunological landscape and immunotherapy of hepatocellular carcinoma.Cutting edge: epigenetic regulation of Foxp3 defines a stable population of CD4+ regulatory T cells in tumors from mice and humans.Association between autoimmune pancreatitis and malignancy.L1CAM promotes enrichment of immunosuppressive T cells in human pancreatic cancer correlating with malignant progression.TGF-β Family Signaling in Tumor Suppression and Cancer Progression.Myxoma Virus Optimizes Cisplatin for the Treatment of Ovarian Cancer In Vitro and in a Syngeneic Murine Dissemination Model.The fatal alliance of cancer and T cells: How pancreatic tumor cells gather immunosuppressive T cells Interleukin 21 inhibits cancer-mediated FOXP3 induction in naïve human CD4 T cells Retinal pigment epithelial cells induce foxp3(+) regulatory T cells via membrane-bound TGF-β.B lymphocyte inhibition of anti-tumor response depends on expansion of Treg but is independent of B-cell IL-10 secretion.Comparison of circulating and intratumoral regulatory T cells in patients with renal cell carcinoma.Clopidogrel in a combined therapy with anticancer drugs-effect on tumor growth, metastasis, and treatment toxicity: Studies in animal models.

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Tumor-derived TGF-beta mediates conversion of CD4+Foxp3+ regulatory T cells in a murine model of pancreas cancer.

http://www.wikidata.org/entity/Q37389994

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on January 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Tumor-derived TGF-beta mediate ...... rine model of pancreas cancer.

@en

Tumor-derived TGF-beta mediate ...... rine model of pancreas cancer.

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Tumor-derived TGF-beta mediate ...... rine model of pancreas cancer.

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Tumor-derived TGF-beta mediate ...... rine model of pancreas cancer.

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prefLabel

Tumor-derived TGF-beta mediate ...... rine model of pancreas cancer.

@en

Tumor-derived TGF-beta mediate ...... rine model of pancreas cancer.

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Journal of Immunotherapy

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Tumor-derived TGF-beta mediate ...... rine model of pancreas cancer.

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Brian A Belt

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David C Linehan

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Justin W Larson

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Marcus C Tan

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Peter S Goedegebuure

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Timothy J Eberlein

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Tricia A Moo-Young

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William G Hawkins

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P2860

Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses

Administration of a CD25-directed immunotoxin, LMB-2, to patients with metastatic melanoma induces a selective partial reduction in regulatory T cells in vivo.

Foxp3+ CD25- CD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansion.

Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells.

Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells

Innovative treatments for pancreatic cancer.

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12-21

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scholarly article

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10.1097/CJI.0B013E318189F13C

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1

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32

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2009-01-01T00:00:00Z

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19307989

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Aizkuņģa dziedzeris

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3862184

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