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Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loopRNF38 encodes a nuclear ubiquitin protein ligase that modifies p53Ribosomal protein S3: A multi-functional protein that interacts with both p53 and MDM2 through its KH domainMass spectrometry-based detection and assignment of protein posttranslational modificationsTargeting DNA damage response in cancer therapyProlyl isomerase Pin1 acts as a switch to control the degree of substrate ubiquitylation.Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation.Myc proteins as therapeutic targets.Insulin receptor tyrosine kinase substrate enhances low levels of MDM2-mediated p53 ubiquitination.Targeting wild-type and mutant p53 with small molecule CP-31398 blocks the growth of rhabdomyosarcoma by inducing reactive oxygen species-dependent apoptosis.Ubiquitin and ubiquitin-like proteins in the nucleolus: multitasking tools for a ribosome factory.DBC1 functions as a tumor suppressor by regulating p53 stabilityDysfunction of the TP53 tumor suppressor gene in lymphoid malignancies.The Ubiquitin Proteasome Pathway (UPP) in the regulation of cell cycle control and DNA damage repair and its implication in tumorigenesisESCRT & Co.Ubiquitination of E3 ligases: self-regulation of the ubiquitin system via proteolytic and non-proteolytic mechanisms.p53-Dependent pathways in neurite outgrowth and axonal regeneration.Corilagin inhibits hepatocellular carcinoma cell proliferation by inducing G2/M phase arrest.Induction of ASAP (MAP9) contributes to p53 stabilization in response to DNA damage.NUB1 promotes cytoplasmic localization of p53 through cooperation of the NEDD8 and ubiquitin pathways.Phosphorylation of p53 at threonine 155 is required for Jab1-mediated nuclear export of p53.Why is F19Ap53 unable to bind MDM2? Simulations suggest crack propagation modulates binding.Wild-type and cancer-related p53 proteins are preferentially degraded by MDM2 as dimers rather than tetramers.Corilagin induces the apoptosis of hepatocellular carcinoma cells through the mitochondrial apoptotic and death receptor pathways.
P2860
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P2860
description
article científic
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article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on 12 February 2009
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
p53 ubiquitination by Mdm2: a never ending tail?
@en
p53 ubiquitination by Mdm2: a never ending tail?
@nl
type
label
p53 ubiquitination by Mdm2: a never ending tail?
@en
p53 ubiquitination by Mdm2: a never ending tail?
@nl
prefLabel
p53 ubiquitination by Mdm2: a never ending tail?
@en
p53 ubiquitination by Mdm2: a never ending tail?
@nl
P1433
P1476
p53 ubiquitination by Mdm2: a never ending tail?
@en
P2093
Nicholas B La Thangue
P304
P356
10.1016/J.DNAREP.2009.01.008
P577
2009-02-12T00:00:00Z