Ethanol modulates BKCa channels by acting as an adjuvant of calcium
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Simulation of alcohol action upon a detailed Purkinje neuron model and a simpler surrogate model that runs >400 times fasterBK channels: multiple sensors, one activation gateEthanol modulation of mammalian BK channels in excitable tissues: molecular targets and their possible contribution to alcohol-induced altered behaviorThe BK channel accessory beta1 subunit determines alcohol-induced cerebrovascular constrictionConserved single residue in the BK potassium channel required for activation by alcohol and intoxication in C. elegans.An alcohol-sensing site in the calcium- and voltage-gated, large conductance potassium (BK) channel.Presynaptic BK channels modulate ethanol-induced enhancement of GABAergic transmission in the rat central amygdala nucleusEthanol-mediated relaxation of guinea pig urinary bladder smooth muscle: involvement of BK and L-type Ca2+ channelsSpecificity of cholesterol and analogs to modulate BK channels points to direct sterol-channel protein interactionsFunctional upregulation of Ca(2+)-activated K(+) channels in the development of substantia nigra dopamine neurons.Activation of calcium- and voltage-gated potassium channels of large conductance by leukotriene B4Type 2 ryanodine receptors are highly sensitive to alcoholLarge conductance, calcium- and voltage-gated potassium (BK) channels: regulation by cholesterol.Functional Interactions between BKCaα-Subunit and Annexin A5: Implications in Apoptosis.Excitation of rat cerebellar Golgi cells by ethanol: further characterization of the mechanism.Distinct sensitivity of slo1 channel proteins to ethanol.Structural determinants of monohydroxylated bile acids to activate beta 1 subunit-containing BK channelsAcute alcohol action and desensitization of ligand-gated ion channels.Alcohol modulation of BK channel gating depends on β subunit compositionSizing up ethanol-induced plasticity: the role of small and large conductance calcium-activated potassium channels.Modulation of BK Channels by Ethanol.BK Channels: mediators and models for alcohol toleranceTargeting BK (big potassium) channels in epilepsy.BKCa channel dysfunction in neurological diseasesGenomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol-Response Behaviors in Model Organisms.The GPR55 agonist lysophosphatidylinositol acts as an intracellular messenger and bidirectionally modulates Ca2+ -activated large-conductance K+ channels in endothelial cells.Putative calcium-binding domains of the Caenorhabditis elegans BK channel are dispensable for intoxication and ethanol activation.Acetaldehyde-ethanol interactions on calcium-activated potassium (BK) channels in pituitary tumor (GH3) cells.Distinct mechanisms underlying cholesterol protection against alcohol-induced BK channel inhibition and resulting vasoconstriction.Ethanol Effect on BK Channels is Modulated by Magnesium.Voltage-Sensitive Potassium Channels of the BK Type and Their Coding Genes Are Alcohol Targets in Neurons.BK β1 subunit-dependent facilitation of ethanol inhibition of BK current and cerebral artery constriction is mediated by the β1 transmembrane domain 2.Acute alcohol exposure impairs neural representation of visual motion speed in the visual cortex area posteromedial lateral suprasylvian cortex of cats.Low-Dose Ethanol Preconditioning Protects Against Oxygen-Glucose Deprivation/Reoxygenation-Induced Neuronal Injury By Activating Large Conductance, Ca2+-Activated K+ Channels In Vitro.
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P2860
Ethanol modulates BKCa channels by acting as an adjuvant of calcium
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 13 June 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Ethanol modulates BKCa channels by acting as an adjuvant of calcium
@en
Ethanol modulates BKCa channels by acting as an adjuvant of calcium.
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type
label
Ethanol modulates BKCa channels by acting as an adjuvant of calcium
@en
Ethanol modulates BKCa channels by acting as an adjuvant of calcium.
@nl
prefLabel
Ethanol modulates BKCa channels by acting as an adjuvant of calcium
@en
Ethanol modulates BKCa channels by acting as an adjuvant of calcium.
@nl
P2093
P2860
P356
P1476
Ethanol modulates BKCa channels by acting as an adjuvant of calcium
@en
P2093
Abby Parrill
Alejandro M Dopico
Jianxi Liu
Kandiah Manivannan
Thirumalini Vaithianathan
P2860
P304
P356
10.1124/MOL.108.048694
P577
2008-06-13T00:00:00Z